Hematopoiesis News Volume 14.42 | Oct 24 2023

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    2023-10-24 | HN 14.42


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.42 – 24 October, 2023
    TOP STORY

    Systematic Evaluation of AML-Associated Antigens Identifies Anti-U5 SNRNP200 Therapeutic Antibodies for the Treatment of Acute Myeloid Leukemia

    High-density immunophenotyping of AML coupled with proteogenomics identified unique expression of a variety of antigens, including the RNA helicase U5 snRNP200, on the surface of AML cells.
    [Nature Cancer]

    Full Article
    Cell Preparation For Crossmatch Assays
    PUBLICATIONSRanked by the impact factor of the journal

    A Gain-of-Function p53 Mutant Synergizes with Oncogenic NRAS to Promote Acute Myeloid Leukemia in Mice

    Researchers reported that in contrast to mixed AML and T cell malignancy developed in NrasG12D/+; p53-/- mice, NrasG12D/+; p53R172H/+ mice rapidly developed an inflammation-associated AML.
    [Journal Of Clinical Investigation]

    AbstractGraphical Abstract

    Hematopoietic Stem Cells Undergo a Lymphoid to Myeloid Switch in Early Stages of Emergency Granulopoiesis

    Using a mouse model of emergency granulopoiesis, the authors observed transcriptional changes in HSCs as early as four hours after lipopolysaccharide administration.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Iron Overload Induces Dysplastic Erythropoiesis and Features of Myelodysplasia in Nrf2-Deficient Mice

    Scientists investigated erythropoiesis and the development of myelodysplasia in mouse models of iron overload and compromised antioxidant response.
    [Leukemia]

    Abstract

    Complete miRNA-15/16 Loss in Mice Promotes Hematopoietic Progenitor Expansion and a Myeloid-Biased Hyperproliferative State

    Investigators demonstrated that the myeloproliferative phenotype in double knockout mice correlated with an increase of hematopoietic stem and progenitor cells early in life.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Akkermansia muciniphila Induces Slow Extramedullary Hematopoiesis via Cooperative IL-1R/TLR Signals

    Researchers found that systemic single injections of Akkermansia muciniphila, a mucin-degrading bacterium, rapidly activated bone marrow myelopoiesis and slowed long-lasting hepato-splenomegaly.
    [EMBO Reports]

    AbstractGraphical Abstract

    A Conserved ZFX/WNT3 Axis Modulates the Growth and Imatinib Response of Chronic Myeloid Leukemia Stem/Progenitor Cells

    Investigators identified a novel zinc finger protein X-linked (ZFX)/WNT3 axis that modulated the growth and imatinib mesylate response of chronic myeloid leukemia stem/progenitor cells.
    [Cellular & Molecular Biology Letters]

    Full Article

    Identification of Multivariable MicroRNA and Clinical Biomarker Panels to Predict Imatinib Response in Chronic Myeloid Leukemia at Diagnosis

    Scientists analyzed clinical data and differentially expressed miRNAs in CD34+ chronic myeloid leukemia cells from 80 patients at diagnosis who were later classified as imatinib-responders or imatinib-nonresponders.
    [Leukemia]

    AbstractGraphical Abstract

    Low Doses of IFN-γ Maintain Self-Renewal of Leukemia Stem Cells in Acute Myeloid Leukemia

    Researchers found that low serum interferon-γ (IFN-γ) levels correlated with a higher percentage of leukemia stem cells and greater relapse incidence in AML patients.
    [Oncogene]

    Abstract
    Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    REVIEWS

    A Guide to Epigenetics in Leukemia Stem Cells

    Scientists discuss the key principles of deregulation of epigenetic processes that shape leukemia stem cells’ evolution. They also discuss efforts to identify mechanisms of resistance, by longitudinal analysis of patient samples.
    [Molecular Oncology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Dr. Stephen D. Nimer Named Researcher of the Year

    BioFlorida has named Stephen D. Nimer, MD, director of Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, “Researcher of the Year.”
    [University of Miami Miller School of Medicine]

    Press Release
    FEATURED EVENT

    Cell 2023

    November 7 – 8, 2023
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Hematology & Cellular Therapy

    Cedars-Sinai – Los Angeles, California, United States

    Clinical Research Coordinator – Hematology

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Associate – Immune Cells in Blood Diseases and GvHD

    Baylor College of Medicine – Houston, Texas, United States

    Assistant Professor – Biochemistry and Molecular and Cellular Biology

    Georgetown University – Washington, Pennsylvania, United States

    Clinical Research Coordinator – Pediatric Oncology, Leukemia & Neuroblastoma

    University of San Francisco – San Francisco, California, United States

    > See All Jobs

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