| Vol. 8.37 – 20 November, 2023 |
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| The authors reported the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting of a magnetized polycaprolactone-based composite. [Small] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers studied the role of the transcription factor NFYa in developing mouse hearts. Loss of NFYa altered cardiomyocyte composition, causing a decrease in immature regenerative cells and an increase in trabecular and mature cardiomyocytes, as identified by spatial and single-cell transcriptome analyses. [Developmental Cell] |
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| Using a GFP-based reporter system, the authors demonstrated that the efficiency of nonhomologous end joining declined by 50% in Hutchinson–Gilford progeria syndrome (HGPS) cardiomyocytes in vivo, due to the attenuated interaction between γH2AX and Progerin, the causative factor of HGPS. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators delineated an integrated, time-ordered transcriptional network that began with expression of genes for cell-cell connections and led to a sequence of structural, cell-cycle, functional, and metabolic transitions in mouse postnatal hearts. [Cell Reports] |
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| Scientists determined the extent to which cardiomyocyte circadian clock disruption impacted cardiac small RNA species. [Communications Biology] |
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| Using transgenic mice in which Zeb1 or Zeb2 were specifically deleted in skeletal myofibers, researchers showed that in fasted mice, the deletion of Zeb1, but not Zeb2, increased reactive oxygen species production. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists highlighted stellate-specific expression of transcripts encoding the collagen-processing enzymes ADAMTS2 and ADAMTS14. [Journal Of Pathology] |
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| Investigators studied the stimulation process and analyzed the distribution of responses in multinuclear cells, in particular looking at the consistency between stimulus and contraction. [Communications Biology] |
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| | Researchers showed defective vascular smooth muscle cell mechanosensation in aging measured with ultrasound tweezers-based micromechanical system, force instantaneous frequency spectrum, and transcriptome analyses. [Aging Cell] |
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| Scientists analyzed clinical data from multiple tissues including meniscus tissue, leukemia cells, and peripheral blood monocytes to identify age-related noncoding RNAs in senescent vascular smooth muscle cells. [Arteriosclerosis Thrombosis And Vascular Biology] |
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| The authors provide a comprehensive overview of the role of the protein kinase C (PKC) δ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis. [Cell Communication and Signaling] |
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| Academia is in the midst of an unprecedented exodus of life science researchers, many of whom are leaving for lucrative jobs in the private sector. [STAT News] |
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| November 28 – 30, 2023 San Francisco, California, United States |
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| Institute of Genetic and Biomedical Research – Milan, Italy |
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| Heidelberg University – Heidelberg, Germany |
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| Columbia University – New York City, New York, United States |
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| National University of Singapore – Singapore, Singapore |
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| Yale University – New Haven, Connecticut, United States |
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