Muscle Cell News Volume 8.37 | Nov 20 2023

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    Noshin Noorjahan
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    2023-11-20 | MUSCN 8.38


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.37 – 20 November, 2023
    TOP STORY

    3D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Models

    The authors reported the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting of a magnetized polycaprolactone-based composite.
    [Small]

    Full Article
    Scale up your cell isolation with Easy 250 EasySepâ„¢ magnet
    PUBLICATIONSRanked by the impact factor of the journal

    Transcription Factor NFYa Controls Cardiomyocyte Metabolism and Proliferation during Mouse Fetal Heart Development

    Researchers studied the role of the transcription factor NFYa in developing mouse hearts. Loss of NFYa altered cardiomyocyte composition, causing a decrease in immature regenerative cells and an increase in trabecular and mature cardiomyocytes, as identified by spatial and single-cell transcriptome analyses.
    [Developmental Cell]

    AbstractGraphical Abstract

    Impaired End Joining Induces Cardiac Atrophy in a Hutchinson–Gilford Progeria Mouse Model

    Using a GFP-based reporter system, the authors demonstrated that the efficiency of nonhomologous end joining declined by 50% in Hutchinson–Gilford progeria syndrome (HGPS) cardiomyocytes in vivo, due to the attenuated interaction between γH2AX and Progerin, the causative factor of HGPS.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Epigenetic Regulator RNF20 Underlies Temporal Hierarchy of Gene Expression to Regulate Postnatal Cardiomyocyte Polarization

    Investigators delineated an integrated, time-ordered transcriptional network that began with expression of genes for cell-cell connections and led to a sequence of structural, cell-cycle, functional, and metabolic transitions in mouse postnatal hearts.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Cardiomyocyte-Specific Disruption of the Circadian BMAL1–REV-ERBα/β Regulatory Network Impacts Distinct miRNA Species in the Murine Heart

    Scientists determined the extent to which cardiomyocyte circadian clock disruption impacted cardiac small RNA species.
    [Communications Biology]

    Full Article

    The Adaptive Antioxidant Response during Fasting-Induced Muscle Atrophy Is Oppositely Regulated by ZEB1 and ZEB2

    Using transgenic mice in which Zeb1 or Zeb2 were specifically deleted in skeletal myofibers, researchers showed that in fasted mice, the deletion of Zeb1, but not Zeb2, increased reactive oxygen species production.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Opposing Roles for ADAMTS2 and ADAMTS14 in Myofibroblast Differentiation and Function

    Scientists highlighted stellate-specific expression of transcripts encoding the collagen-processing enzymes ADAMTS2 and ADAMTS14.
    [Journal Of Pathology]

    Full Article

    Skeletal Muscle Cells Opto-Stimulation by Intramembrane Molecular Transducers

    Investigators studied the stimulation process and analyzed the distribution of responses in multinuclear cells, in particular looking at the consistency between stimulus and contraction.
    [Communications Biology]

    Full Article

    Aging-Associated Decline in Vascular Smooth Muscle Cell Mechanosensation Is Mediated by Piezo1 Channel

    Researchers showed defective vascular smooth muscle cell mechanosensation in aging measured with ultrasound tweezers-based micromechanical system, force instantaneous frequency spectrum, and transcriptome analyses.
    [Aging Cell]

    Full Article

    lncRNA JPX-Enriched Chromatin Microenvironment Mediates Vascular Smooth Muscle Cell Senescence and Promotes Atherosclerosis

    Scientists analyzed clinical data from multiple tissues including meniscus tissue, leukemia cells, and peripheral blood monocytes to identify age-related noncoding RNAs in senescent vascular smooth muscle cells.
    [Arteriosclerosis Thrombosis And Vascular Biology]

    Abstract
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    REVIEWS

    PKCδ Regulates the Vascular Biology in Diabetic Atherosclerosis

    The authors provide a comprehensive overview of the role of the protein kinase C (PKC) δ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis.
    [Cell Communication and Signaling]

    Full Article
    INDUSTRY AND POLICY NEWS

    Life Scientists’ Flight to Biotech Labs Stalls Important Academic Research

    Academia is in the midst of an unprecedented exodus of life science researchers, many of whom are leaving for lucrative jobs in the private sector.
    [STAT News]

    Editorial
    FEATURED EVENT

    Donor Selection & Cell Source Summit

    November 28 – 30, 2023
    San Francisco, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Cardiac and Skeletal Muscle Research

    Institute of Genetic and Biomedical Research – Milan, Italy

    PhD Position: Multi-Omics Data Study

    Heidelberg University – Heidelberg, Germany

    Staff Associate – Cardiomyocytes

    Columbia University – New York City, New York, United States

    Research Fellow – Biological Sciences

    National University of Singapore – Singapore, Singapore

    Postdoctoral Fellow – Medicine and Genetics

    Yale University – New Haven, Connecticut, United States

    > See All Jobs

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