| Vol. 15.46 – 1 December, 2023 |
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| Scientists identified OTULIN deficiency as a cellular condition that licensed RIPK3-mediated cell death in murine macrophages, leading to Nlrp3 inflammasome activation and subsequent IL-1β secretion. [Science Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that mice deficient in Zbtb24 in the hematopoietic lineage recapitulated the major clinical features of patients with immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome. [Cellular & Molecular Immunology] |
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| Researchers demonstrated that Th17 cell-associated experimental autoimmune encephalomyelitis was greatly exacerbated in C1q/TNF related protein 4 (CTRP4)-/- mice compared to WT mice due to increased Th17 cell infiltration. [Journal of Clinical Investigation] |
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| Scientists showed that the combination of engineered, tumor matrix-binding IL-7 and IL-12 achieved remarkable anticancer effects by activating complementary pathways without inducing any additive immunotoxicity. [Science Advances] |
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| Investigators showed that autoimmunity, caused by conventional T cells expressing constitutively active MALT1 paracaspase, was triggered by cleavage of a single substrate, the RNA-binding protein Roquin-1. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors found that granzyme A- and B-producing Th2 cells played a key role in the promotion of pathogenic Th2 cells via protease-activated receptor (Par)-1 and induced the phosphorylation of p38 mitogen-activated protein kinase. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| By regulating the mTOR-T-bet axis, ginseng-derived nanoparticles reprogramed macrophages to regulate arginase-1 release, which further ameliorated T cell exhaustion in tumor microenvironment. [Journal of Experimental & Clinical Cancer Research] |
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| Scientists showed that the transfer of G-protein-coupled receptor 84 (GPR84) from myeloid-derived suppressor cells (MDSCs) to CD8+ T cells via the exosomes attenuated the antitumor response. [Journal for Immunotherapy of Cancer] |
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| Researchers investigated the mechanisms underlying programmed cell death molecule 1 (PD-1)–mediated inhibition. Their findings suggested an alternative mechanism by which PD-1 regulates immune responses. [Science Signaling] |
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| The authors elucidate functional differences between γδ T cells and their αβ T cell counterparts and provide an overview of major milestones in γδ T cell research since their discovery in 1984. [Signal Transduction and Targeted Therapy] |
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| The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults. [Oklahoma Medical Research Foundation] |
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| January 17 – 19, 2024 Chiba, Japan |
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| Institut Necker Enfants Malades – Paris, France |
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| Westlake University – Zhejiang, China |
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| Rutgers Health – Newark, New Jersey, United States |
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| University of Melbourne – Melbourne, Australia |
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| NIH National Cancer Institute – Bethesda, Maryland, United States |
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