Immune Regulation News Volume 15.46 | Dec 1 2023

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    2023-12-01 | IRN 15.46


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.46 – 1 December, 2023
    TOP STORY

    Myeloid OTULIN Deficiency Couples RIPK3-Dependent Cell Death to Nlrp3 Inflammasome Activation and IL-1β Secretion

    Scientists identified OTULIN deficiency as a cellular condition that licensed RIPK3-mediated cell death in murine macrophages, leading to Nlrp3 inflammasome activation and subsequent IL-1β secretion.
    [Science Immunology]

    Abstract
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    PUBLICATIONSRanked by the impact factor of the journal

    Enhanced CD19 Activity in B Cells Contributes to Immunodeficiency in Mice Deficient in the ICF Syndrome Gene Zbtb24

    Investigators showed that mice deficient in Zbtb24 in the hematopoietic lineage recapitulated the major clinical features of patients with immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome.
    [Cellular & Molecular Immunology]

    Abstract

    CTRP4/Interleukin-6 Receptor Signaling Ameliorates Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation

    Researchers demonstrated that Th17 cell-associated experimental autoimmune encephalomyelitis was greatly exacerbated in C1q/TNF related protein 4 (CTRP4)-/- mice compared to WT mice due to increased Th17 cell infiltration.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    Engineered IL-7 Synergizes with IL-12 Immunotherapy to Prevent T Cell Exhaustion and Promote Memory without Exacerbating Toxicity

    Scientists showed that the combination of engineered, tumor matrix-binding IL-7 and IL-12 achieved remarkable anticancer effects by activating complementary pathways without inducing any additive immunotoxicity.
    [Science Advances]

    Full Article

    Unrestrained Cleavage of Roquin-1 by MALT1 Induces Spontaneous T Cell Activation and the Development of Autoimmunity

    Investigators showed that autoimmunity, caused by conventional T cells expressing constitutively active MALT1 paracaspase, was triggered by cleavage of a single substrate, the RNA-binding protein Roquin-1.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    The USP7-STAT3-Granzyme-Par-1 Axis Regulates Allergic Inflammation by Promoting Differentiation of IL-5-Producing Th2 Cells

    The authors found that granzyme A- and B-producing Th2 cells played a key role in the promotion of pathogenic Th2 cells via protease-activated receptor (Par)-1 and induced the phosphorylation of p38 mitogen-activated protein kinase.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Ginseng-Derived Nanoparticles Reprogram Macrophages to Regulate Arginase-1 Release for Ameliorating T Cell Exhaustion in Tumor Microenvironment

    By regulating the mTOR-T-bet axis, ginseng-derived nanoparticles reprogramed macrophages to regulate arginase-1 release, which further ameliorated T cell exhaustion in tumor microenvironment.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    MDSCs-Derived GPR84 Induces CD8+ T Cell Senescence via p53 Activation to Suppress the Antitumor Response

    Scientists showed that the transfer of G-protein-coupled receptor 84 (GPR84) from myeloid-derived suppressor cells (MDSCs) to CD8+ T cells via the exosomes attenuated the antitumor response.
    [Journal for Immunotherapy of Cancer]

    Full Article

    PD-1 Inhibits T Cell Actin Remodeling at the Immunological Synapse Independently of Its Signaling Motifs

    Researchers investigated the mechanisms underlying programmed cell death molecule 1 (PD-1)–mediated inhibition. Their findings suggested an alternative mechanism by which PD-1 regulates immune responses.
    [Science Signaling]

    Abstract
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    REVIEWS

    γδ T Cells: Origin and Fate, Subsets, Diseases, and Immunotherapy

    The authors elucidate functional differences between γδ T cells and their αβ T cell counterparts and provide an overview of major milestones in γδ T cell research since their discovery in 1984.
    [Signal Transduction and Targeted Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    OMRF Scientist Awarded $3.4 Million to Investigate Immune Cells

    The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults.
    [Oklahoma Medical Research Foundation]

    Press Release
    FEATURED EVENT

    The 52nd Annual Meeting of the Japanese Society for Immunology

    January 17 – 19, 2024
    Chiba, Japan

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scientists – Regulatory Lymphocytes & Tissue Resident Cells Crosstalk

    Institut Necker Enfants Malades – Paris, France

    Faculty Positions – Medicine

    Westlake University – Zhejiang, China

    Postdoctoral Research Scientist – Immunity and Inflammation

    Rutgers Health – Newark, New Jersey, United States

    Research Officer – Translational Immunology

    University of Melbourne – Melbourne, Australia

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    > See All Jobs

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