| Vol. 15.49 – 12 December, 2023 |
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| Scientists investigated the effects of apoptotic bodies (ABs) derived from MSCs on periodontitis. MSCs were derived from bone marrows of mice and were cultured under hypoxic conditions for 72 hours, after which ABs were isolated from the culture supernatant using a multi-filtration system. [International Journal Of Oral Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators designed a Y-shaped DNA nanostructure to deliver microRNA-122, which could induce the hepatic differentiation and maturation of human MSCs. [ACS Nano ] |
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| Scientists presented evidence that the intravitreal injection of MSC-small extracellular vesicles improved retinal function and alleviated retinal apoptosis, inflammation, and angiogenesis in both db/db mice and streptozotocin-induced diabetic rats. [Bioactive Materials] |
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| Researchers employed an in vitro model of chemically induced ischemia using antimycin A combined with 2-deoxy-D-glucose to induce ischemic injury in proximal tubule epithelial cells. [Current Stem Cell Research & Therapy] |
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| MSCs were transduced with a recombinant lentivirus encoding Cxcl10, Nrf2, and a ferritin heavy chain reporter gene to increase their CXCL10 secretion, tumor microenvironment survival, and MRI visibility. [Journal Of Immunotherapy] |
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| Sequencing analysis revealed that LINC00707 was significantly decreased in non-adherent human MSCs compared to adherent human MSCs. [Experimental Cell Research] |
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| Researchers evaluated the methyltransferase-like 3 (METTL3) function in vivo. Mice exhibiting a conditional removal of Mettl3 in bone marrow MSCs were developed by mating Prrx1-CreERT2;Mettl3fl/+ mice with Mettl3fl/fl mice using the CRISPR-Cas9 system. [Cell Death & Disease] |
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| Scientists compared human umbilical cord (hUC)-MSC in vivo engraftment efficacy and cytokine expression for both hUC-MSC sheets and cell suspensions. [Stem Cell Research & Therapy] |
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| ICR mice were pretreated with human umbilical cord (hUC) MSCs and then infected with the influenza H7N9 virus. Weight, survival days, and lung index of mice were recorded. [Biochimica Et Biophysica Acta-Molecular Basis Of Disease] |
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| The authors summarize the most recent outcomes on the usage of adipose-derived MSCs in the treatment of long-term complications of diabetes in both animal models and clinical trials. [Diabetes Obesity & Metabolism] |
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| Gallant Therapeutics announced the launch of a pivotal study to evaluate the safety and efficacy of its novel allogeneic stem cell therapy candidate to support FDA conditional approval in cats with refractory feline chronic gingivostomatitis, the JEDI study. [Gallant Therapeutics (Globe Newswire)] |
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| January 27 – 30, 2024 Pacific Grove, California, United States |
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| University of Nottingham – Nottingham, Scotland, United Kingdom |
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| University of Texas Health Science Center at San Antonio – San Antonio, Texas, United States |
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| University of Sydney – Camperdown, Australia |
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| Institut Pasteur – Paris, France |
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| Applied Stem Cell – Milpitas, California, United States |
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