Mesenchymal Cell News Volume 15.49 | Dec 12 2023

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    2023-12-12 | MESCN 15.49


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.49 – 12 December, 2023
    TOP STORY

    Mesenchymal Stem Cell-Derived Apoptotic Bodies Alleviate Alveolar Bone Destruction by Regulating Osteoclast Differentiation and Function

    Scientists investigated the effects of apoptotic bodies (ABs) derived from MSCs on periodontitis. MSCs were derived from bone marrows of mice and were cultured under hypoxic conditions for 72 hours, after which ABs were isolated from the culture supernatant using a multi-filtration system.
    [International Journal Of Oral Science]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Microfluidic Fabrication of MicroRNA-Induced Hepatocyte-Like Cells/Human Umbilical Vein Endothelial Cells-Laden Microgels for Acute Liver Failure Treatment

    Investigators designed a Y-shaped DNA nanostructure to deliver microRNA-122, which could induce the hepatic differentiation and maturation of human MSCs.
    [ACS Nano ]

    AbstractGraphical Abstract

    Engineered Mesenchymal Stem Cell-Derived Small Extracellular Vesicles for Diabetic Retinopathy Therapy Through HIF-1α/EZH2/PGC-1α Pathway

    Scientists presented evidence that the intravitreal injection of MSC-small extracellular vesicles improved retinal function and alleviated retinal apoptosis, inflammation, and angiogenesis in both db/db mice and streptozotocin-induced diabetic rats.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    Mesenchymal Stromal Cells Secretome Restores Bioenergetic and Redox Homeostasis in Human Proximal Tubule Cells after Ischemic Injury

    Researchers employed an in vitro model of chemically induced ischemia using antimycin A combined with 2-deoxy-D-glucose to induce ischemic injury in proximal tubule epithelial cells.
    [Current Stem Cell Research & Therapy]

    Full Article

    CXCL10 and Nrf2-Upregulated Mesenchymal Stem Cells Reinvigorate T Lymphocytes for Combating Glioblastoma

    MSCs were transduced with a recombinant lentivirus encoding Cxcl10, Nrf2, and a ferritin heavy chain reporter gene to increase their CXCL10 secretion, tumor microenvironment survival, and MRI visibility.
    [Journal Of Immunotherapy]

    Full Article

    Non-Adherent Culture Method Affects the Proliferation and Apoptosis of Mesenchymal Stem Cells through Inhibiting LINC00707 to Promote RNF6-Mediated QKI Ubiquitination

    Sequencing analysis revealed that LINC00707 was significantly decreased in non-adherent human MSCs compared to adherent human MSCs.
    [Experimental Cell Research]

    Full ArticleGraphical Abstract

    Deletion of Mettl3 in Mesenchymal Stem Cells Promotes Acute Myeloid Leukemia Resistance to Chemotherapy

    Researchers evaluated the methyltransferase-like 3 (METTL3) function in vivo. Mice exhibiting a conditional removal of Mettl3 in bone marrow MSCs were developed by mating Prrx1-CreERT2;Mettl3fl/+ mice with Mettl3fl/fl mice using the CRISPR-Cas9 system.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    Umbilical Cord-Derived Mesenchymal Stem Cell Sheets Transplanted Subcutaneously Enhance Cell Retention and Survival More than Dissociated Stem Cell Injections

    Scientists compared human umbilical cord (hUC)-MSC in vivo engraftment efficacy and cytokine expression for both hUC-MSC sheets and cell suspensions.
    [Stem Cell Research & Therapy]

    Abstract

    Mesenchymal Stem Cells Prevent H7N9 Virus Infection via Rejuvenating Immune Environment to Inhibit Immune-Overactivity

    ICR mice were pretreated with human umbilical cord (hUC) MSCs and then infected with the influenza H7N9 virus. Weight, survival days, and lung index of mice were recorded.
    [Biochimica Et Biophysica Acta-Molecular Basis Of Disease]

    Abstract
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    REVIEWS

    Efficacy of Adipose-Derived Mesenchymal Stem Cell Therapy in the Treatment of Chronic Micro- and Macrovascular Complications of Diabetes

    The authors summarize the most recent outcomes on the usage of adipose-derived MSCs in the treatment of long-term complications of diabetes in both animal models and clinical trials.
    [Diabetes Obesity & Metabolism]

    Full Article
    INDUSTRY AND POLICY NEWS

    Gallant Therapeutics Announces Launch of JEDI Pivotal Study for First Allogeneic Stem Cell Therapy Targeting Feline Chronic Gingivostomatitis

    Gallant Therapeutics announced the launch of a pivotal study to evaluate the safety and efficacy of its novel allogeneic stem cell therapy candidate to support FDA conditional approval in cats with refractory feline chronic gingivostomatitis, the JEDI study.
    [Gallant Therapeutics (Globe Newswire)]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

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    University of Nottingham – Nottingham, Scotland, United Kingdom

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    University of Sydney – Camperdown, Australia

    Postdoctoral Position – Inflammation/Regeneration

    Institut Pasteur – Paris, France

    Research Associate – Cell Biology R&D

    Applied Stem Cell – Milpitas, California, United States

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