| Vol. 8.00 – 5 January, 2024 |
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| To induce spontaneous or forced liver metastasis in mice, murine cancer cells or colon tumor organoids were injected into the cecum or the spleen, respectively. [Journal Of Hepatology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators proposed an antifibrotic strategy that combined prosenescence with enhanced immune clearance through targeted delivery of manganese via albumin-mediated transcytosis, specifically aimed at inducing senescence and eliminating activated HSCs in liver fibrosis. [Nano Letters] |
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| Scientists aimed to develop basic fibroblast growth factor (bFGF)-releasing nanoparticles to prolong the survival of hepatocyte sheets after transplantation. [Journal Of Controlled Release] |
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| Cellular interactions and soluble mediators involved in T cell polarization and recruitment were studied, as well as their effect on HSC activation, proliferation, and extracellular matrix synthesis. [Cellular And Molecular Gastroenterology And Hepatology] |
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| The depletion of sestrin2 resulted in excessive necroptosis, accompanied by increased fat accumulation, inflammation, and oxidative stress in the experimental steatohepatitis model. [Molecular Metabolism] |
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| Researchers aimed to improve HCC therapy by evaluating combination treatment using anti-cancer and anti-fibrosis drugs via identification of novel anti-fibrosis drugs. [Scientific Reports] |
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| Detailed transcriptome analysis revealed that fibroblast growth factor signaling, the essential pathway for hepatocyte proliferation during liver regeneration, was mainly enriched in proliferative liver organoids. [Scientific Reports] |
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| Researchers evaluated the possible role of OMA1/YME1L in HCC staging and discussed their potential role in cellular apoptosis and proliferation. They used four groups of male albino rats: a normal control and three diethyl nitrosamine-treated groups for 8, 16, and 24 weeks. [Yale Journal Of Biology And Medicine] |
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| A systematic approach to investigating the initial seeding density of endothelial cells and its effects on interconnected networks was taken and combined with hepatic spheroids to form a liver-on-a-chip model. [Biomicrofluidics] |
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| The authors discuss pertinent studies concerning Tregs in hepatitis B virus (HBV) infection, HBV-related cirrhosis, and HCC. Furthermore, they summarize Treg responses to antiviral therapy and provide Treg-targeted therapies specific to HBV and HCC. [Immunology] |
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| Dozens of science and technology development payloads returned to Earth from the ISS as SpaceX’s 29th Commercial Resupply Services (CRS) mission, contracted by NASA, successfully concluded. [ISS National Lab] |
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| February 14 – 18, 2024 Cancun, Mexico |
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| University of California San Francisco – San Francisco, California, United States |
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| Cedars-Sinai – Los Angeles, California, United States |
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| Human Technopole – Location |
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| National University of Singapore – Singapore, Singapore |
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| Virginia Tech – Blacksburg, Virginia, United States |
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