Hepatic Cell News Volume 8.00 | Jan 05 2024

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    2024-01-05 | HCN 8.00


    Hepatic Cell News by STEMCELL Technologies
    Vol. 8.00 – 5 January, 2024
    TOP STORY

    IL-10 Dampens Antitumor Immunity and Promotes Liver Metastasis via PD-L1 Induction

    To induce spontaneous or forced liver metastasis in mice, murine cancer cells or colon tumor organoids were injected into the cecum or the spleen, respectively.
    [Journal Of Hepatology]

    Full ArticleGraphical Abstract
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    Senescence of Hepatic Stellate Cells by Specific Delivery of Manganese for Limiting Liver Fibrosis

    Investigators proposed an antifibrotic strategy that combined prosenescence with enhanced immune clearance through targeted delivery of manganese via albumin-mediated transcytosis, specifically aimed at inducing senescence and eliminating activated HSCs in liver fibrosis.
    [Nano Letters]

    AbstractGraphical Abstract

    bFGF-Releasing Biodegradable Nanoparticles for Effectively Engrafting Transplanted Hepatocyte Sheet

    Scientists aimed to develop basic fibroblast growth factor (bFGF)-releasing nanoparticles to prolong the survival of hepatocyte sheets after transplantation.
    [Journal Of Controlled Release]

    Full ArticleGraphical Abstract

    Th2 Cell Activation in Chronic Liver Disease Is Driven by Local IL-33 and Contributes to IL-13 Dependent Fibrogenesis

    Cellular interactions and soluble mediators involved in T cell polarization and recruitment were studied, as well as their effect on HSC activation, proliferation, and extracellular matrix synthesis.
    [Cellular And Molecular Gastroenterology And Hepatology]

    AbstractGraphical Abstract

    Sestrin2 Maintains Hepatic Immune Homeostasis and Redox Balance Partially via Inhibiting RIPK3-Mediated Necroptosis in Metabolic Dysfunction-Associated Steatohepatitis

    The depletion of sestrin2 resulted in excessive necroptosis, accompanied by increased fat accumulation, inflammation, and oxidative stress in the experimental steatohepatitis model.
    [Molecular Metabolism]

    Abstract

    Inhibition of DNMT3B Expression in Activated Hepatic Stellate Cells Overcomes Chemoresistance in the Tumor Microenvironment of Hepatocellular Carcinoma

    Researchers aimed to improve HCC therapy by evaluating combination treatment using anti-cancer and anti-fibrosis drugs via identification of novel anti-fibrosis drugs.
    [Scientific Reports]

    Full Article

    Efficient and Reproducible Generation of Human Induced Pluripotent Stem Cell-Derived Expandable Liver Organoids for Disease Modeling

    Detailed transcriptome analysis revealed that fibroblast growth factor signaling, the essential pathway for hepatocyte proliferation during liver regeneration, was mainly enriched in proliferative liver organoids.
    [Scientific Reports]

    Full Article

    OMA1 and YME1L as a Diagnostic Panel in Hepatocellular Carcinoma

    Researchers evaluated the possible role of OMA1/YME1L in HCC staging and discussed their potential role in cellular apoptosis and proliferation. They used four groups of male albino rats: a normal control and three diethyl nitrosamine-treated groups for 8, 16, and 24 weeks.
    [Yale Journal Of Biology And Medicine]

    Full Article

    Vascularized Liver-on-a-Chip Model to Investigate Nicotine-Induced Dysfunction

    A systematic approach to investigating the initial seeding density of endothelial cells and its effects on interconnected networks was taken and combined with hepatic spheroids to form a liver-on-a-chip model.
    [Biomicrofluidics]

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    REVIEWS

    The Dual Role of Regulatory T Cells in Hepatitis B Virus Infection and Related Hepatocellular Carcinoma

    The authors discuss pertinent studies concerning Tregs in hepatitis B virus (HBV) infection, HBV-related cirrhosis, and HCC. Furthermore, they summarize Treg responses to antiviral therapy and provide Treg-targeted therapies specific to HBV and HCC.
    [Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    SpaceX Returns Vital Life Science Research Sponsored by the ISS National Lab

    Dozens of science and technology development payloads returned to Earth from the ISS as SpaceX’s 29th Commercial Resupply Services (CRS) mission, contracted by NASA, successfully concluded.
    [ISS National Lab]

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    JOB OPPORTUNITIES

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    University of California San Francisco – San Francisco, California, United States

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    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Researcher – Computational Cancer Evolution

    Human Technopole – Location

    Research Assistant – Hepatitis Research Program

    National University of Singapore – Singapore, Singapore

    Postdoctoral Associate – Hepatitis E Virus Mechanism

    Virginia Tech – Blacksburg, Virginia, United States

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