| Vol. 5.01 – 11 January, 2024 |
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| Researchers designed a high-content imaging assay based on morphological and functional readouts in human pluripotent stem cell-derived cortical neurons which identified multiple compounds that drive neuronal maturation. [Nature Biotechnology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigatorss showed that the healthy human fetal brain in vitro self-organized into organoids, phenocopying aspects of in vivo cellular heterogeneity and complex organization. [Cell] |
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| The authors established a new potential preclinical model for malignant peritoneal mesothelioma (MPM) using patient-derived MPM organoids and to comprehensively evaluate the practicality of this model in medical research and its feasibility in guiding individualized patient treatment. [Molecular Cancer] |
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| The hypothesis that mechanical signals regulate nephrogenesis was investigated in 3D culture by encapsulating kidney organoids within viscoelastic alginate hydrogels with varying rates of stress relaxation. [Advanced Materials] |
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| Researchers explored the precancerous nature of intestinal metaplasia (IM) by analysing epigenetic alterations. Genome-wide DNA methylation analysis was conducted by EPIC BeadArray using IM crypts isolated by Alcian blue staining. [Gut] |
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| A single-cell RNA expression atlas of primary and cultured human conjunctiva revealed that keratinocytes expressed multiple antimicrobial peptides and identifies conjunctival tuft cells. [Cell Stem Cell] |
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| Investigators formed embryoid bodies in an ultra-low attachment 384-well plate and subsequently transferred them to the pillar plate containing Matrigel, using a straightforward sandwiching and inverting method. [Biofabrication] |
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| Researchers used a mouse intestinal organoid combined with cell model to explore the differences in metabolites and toxicity mechanisms induced by exposure to three nanoplastics. [Science Of The Total Environment] |
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| Using a cerebral organoid model of early human brain development, scientists found that PANX1 was expressed at all stages of organoid development from neural induction through to neuroepithelial expansion and maturation. [Cell Death Discovery] |
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| Investigators found that TNFα could induce stemness and activate senescence signaling by enhancing cell plasticity in colonic epithelial cells, which could act as a selective pressure to mutate senescence-related genes in inflammation-associated colonic tumors. [Nature Communications] |
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| Researchers monitored the long- and short-term effects of mammalian target of rapamycin (mTOR) signaling regulation on cerebral organoid growth, differentiation, and function using an mTOR inhibitor and an mTOR activator. [Tissue Engineering And Regenerative Medicine] |
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| In vitro models that can adequately mimic in vivo gastrointestinal physiology are in high demand to elucidate mechanisms behind pathogen infectivity, and to aid the design of effective preventive and therapeutic interventions. [Advanced Science] |
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| The authors highlight the cutting-edge achievements in human organoids-on-chips (OrgOCs), introduce the key features of OrgOCs architectures, and share the revolutionary applications in basic biology, disease modeling, preclinical assay and precision medicine. [Theranostics] |
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| More than two dozen investigations sponsored by the International Space Station (ISS) National Laboratory, many of which focus on the life sciences, will fly on Axiom Space’s third private astronaut mission to the orbiting laboratory. [ISS National Laboratory] |
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| March 11 – 13, 2024 Lisbon, Portugal |
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| Francis Crick Institute – London, England, United Kingdom |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| Human Technopole – Milan, Italy |
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| Human Technopole – Milan, Italy |
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| Human Technopole – Milan, Italy |
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