Organoid News Volume 5.01 | Jan 11 2024

    By
    lbeveridge
    -
    0
    13








    2024-01-11 | ON 5.02


    Organoid News by STEMCELL Technologies
    Vol. 5.01 – 11 January, 2024
    TOP STORY

    Combined Small-Molecule Treatment Accelerates Maturation of Human Pluripotent Stem Cell-Derived Neurons

    Researchers designed a high-content imaging assay based on morphological and functional readouts in human pluripotent stem cell-derived cortical neurons which identified multiple compounds that drive neuronal maturation.
    [Nature Biotechnology]

    Full Article
    Request a free wallchart showing how organoids can be used to model aspects of human disease.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Fetal Brain Self-Organizes Into Long-Term Expanding Organoids

    Investigatorss showed that the healthy human fetal brain in vitro self-organized into organoids, phenocopying aspects of in vivo cellular heterogeneity and complex organization.
    [Cell]

    Full ArticleGraphical Abstract

    Organoids Derived From Patients Provide a New Opportunity for Research and Individualized Treatment of Malignant Peritoneal Mesothelioma

    The authors established a new potential preclinical model for malignant peritoneal mesothelioma (MPM) using patient-derived MPM organoids and to comprehensively evaluate the practicality of this model in medical research and its feasibility in guiding individualized patient treatment.
    [Molecular Cancer]

    Full Article

    3D Hydrogel Encapsulation Regulates Nephrogenesis in Kidney Organoids

    The hypothesis that mechanical signals regulate nephrogenesis was investigated in 3D culture by encapsulating kidney organoids within viscoelastic alginate hydrogels with varying rates of stress relaxation.
    [Advanced Materials]

    Abstract

    Precancerous Nature of Intestinal Metaplasia With Increased Chance of Conversion and Accelerated DNA Methylation

    Researchers explored the precancerous nature of intestinal metaplasia (IM) by analysing epigenetic alterations. Genome-wide DNA methylation analysis was conducted by EPIC BeadArray using IM crypts isolated by Alcian blue staining.
    [Gut]

    Abstract

    Human Conjunctiva Organoids To Study Ocular Surface Homeostasis and Disease

    A single-cell RNA expression atlas of primary and cultured human conjunctiva revealed that keratinocytes expressed multiple antimicrobial peptides and identifies conjunctival tuft cells.
    [Cell Stem Cell]

    Full ArticlePress ReleaseGraphical Abstract

    Uniform Cerebral Organoid Culture on a Pillar Plate by Simple and Reproducible Spheroid Transfer From an Ultralow Attachment Well Plate

    Investigators formed embryoid bodies in an ultra-low attachment 384-well plate and subsequently transferred them to the pillar plate containing Matrigel, using a straightforward sandwiching and inverting method.
    [Biofabrication]

    Full Article

    Predictive Metabolomic Signatures for Safety Assessment of Three Plastic Nanoparticles Using Intestinal Organoids

    Researchers used a mouse intestinal organoid combined with cell model to explore the differences in metabolites and toxicity mechanisms induced by exposure to three nanoplastics.
    [Science Of The Total Environment]

    AbstractGraphical Abstract

    Apically Localized PANX1 Impacts Neuroepithelial Expansion in Human Cerebral Organoids

    Using a cerebral organoid model of early human brain development, scientists found that PANX1 was expressed at all stages of organoid development from neural induction through to neuroepithelial expansion and maturation.
    [Cell Death Discovery]

    Full Article

    Sleeping Beauty Transposon Mutagenesis Identified Genes and Pathways Involved in Inflammation-Associated Colon Tumor Development

    Investigators found that TNFα could induce stemness and activate senescence signaling by enhancing cell plasticity in colonic epithelial cells, which could act as a selective pressure to mutate senescence-related genes in inflammation-associated colonic tumors.
    [Nature Communications]

    Full Article

    Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations

    Researchers monitored the long- and short-term effects of mammalian target of rapamycin (mTOR) signaling regulation on cerebral organoid growth, differentiation, and function using an mTOR inhibitor and an mTOR activator.
    [Tissue Engineering And Regenerative Medicine]

    AbstractGraphical Abstract
    A Labroots 2021 Webinar: iPSCs As Models, Part 1: What Are Induced Pluripotent Stem Cells and How Do You Use Them?, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    REVIEWS

    In Vitro Models for Investigating Intestinal Host–Pathogen Interactions

    In vitro models that can adequately mimic in vivo gastrointestinal physiology are in high demand to elucidate mechanisms behind pathogen infectivity, and to aid the design of effective preventive and therapeutic interventions.
    [Advanced Science]

    Full Article

    Human Organoids-on-Chips for Biomedical Research and Applications

    The authors highlight the cutting-edge achievements in human organoids-on-chips (OrgOCs), introduce the key features of OrgOCs architectures, and share the revolutionary applications in basic biology, disease modeling, preclinical assay and precision medicine.
    [Theranostics]

    Full Article
    INDUSTRY AND POLICY NEWS

    Stem Cell Investigations to Improve Cancer Treatment Among Payloads Flying on Axiom Space’s Third Private Astronaut Mission

    More than two dozen investigations sponsored by the International Space Station (ISS) National Laboratory, many of which focus on the life sciences, will fly on Axiom Space’s third private astronaut mission to the orbiting laboratory.
    [ISS National Laboratory]

    Full Article
    FEATURED EVENT

    CSMBMEET2024

    March 11 – 13, 2024
    Lisbon, Portugal

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Regulation of Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    Research Assistant – Lung Stem Cells and Disease

    University of Cambridge – Cambridge, England, United Kingdom

    Technician – Patient-Derived Tumor Organoids for Drug Resistance

    Human Technopole – Milan, Italy

    Postdoctoral Researcher – Computational Cancer Evolution

    Human Technopole – Milan, Italy

    Technician – Patient-Derived Tumor Organoids for Drug Resistance

    Human Technopole – Milan, Italy

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2