| Vol. 16.04 – 30 January, 2024 |
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| The immune microenvironment- and MSC fate-regulated citrate-coordinated CGG hydrogels represented a highly efficient and facile approach toward skull bone tissue regeneration with great potential for bench-to-bedside translation. [ACS Applied Materials & Interfaces] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified fructose deteriorated bone mineral density while promoting the abundance of bone marrow adipose tissue. Fructose remarkably promoted the bone marrow MSCs adipogenic commitment at the expense of osteogenic commitment. [Stem Cells] |
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| Researchers generated and characterized an immortalized chronic myeloid leukemia (CML) patient-derived MSC line and assessed its role in leukemic stem cell maintenance. [Cellular Signalling] |
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| Scientists evaluated the immunological activities of human decidual MSCs on proliferation, apoptosis, and percentage of regulatory T cells in abortions and to investigate whether these activities differed in spontaneous abortions and recurrent abortions [Journal Of Reproductive Immunology] |
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| Researchers employed a comprehensive methodology involving the differentiation of induced pluripotent stem cells into mesenchymal stem cells. The process was meticulously designed to ensure the expression of key MSC positive markers at elevated levels, coupled with the minimal expression of negative markers. [Journal Of The Chinese Medical Association] |
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| Gli1 was used as a periodontal MSC marker and combined with a Gli1-cre ERT2 mouse model for lineage tracing to investigate periodontal MSC fate in an induced periodontitis model. [Journal Of Dental Research] |
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| Dental pulp MSCs were loaded to a mucoadhesive hydrogel based on chitosan, cross-linked with genipin, and modified with catechol groups. A dental nickel hypersensitivity model was created by administering NiCl2 and 10 μg/mL LPS to 4-6-week-old Balb-c mice by intradermal injection. [Macromolecular Bioscience] |
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| Researchers explored the effect of exosomes derived from dental pulp stem cells (DPSC-Exos) on the regeneration of myelin sheaths in rats with sciatic nerve injury. In vitro and in vivo experiments were performed to clarify whether the effect of DPSC-Exos was associated with autophagy of Schwann cells. [Molecular Neurobiology] |
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| To investigate the effect of human umbilical cord blood-MSCs on the histological structure, the oxidant stress, and the inflammatory gene expression in an experimental model of cisplatin-induced nephrotoxicity in rats. [Molecular Biology Reports] |
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| Scientists identify the limitations that have to be overcome before stem cell therapy for diabetes becomes reliable and reproducible. As an alternative to cell therapy, the use of stem cell-derived extracellular vesicles is discussed as a future possibility. [Stem Cell Research & Therapy] |
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| The authors focus on mitochondrial mechanistic insights in the whole life course of MSCs, as well as the potential roles played by mitochondria in MSCs treatment of transplantation, for seeking pivotal targets of stem cell fate regulation and stem cell therapy. [Stem Cell Reviews And Reports] |
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| BioCardia®, Inc. announced that the first patient was enrolled and treated in its CardiALLO™ Allogeneic Mesenchymal Cell Therapy Phase I/II trial for the treatment of patients with New York Heart Association Class II and III ischemic heart failure of reduced ejection fraction. [BioCardia®, Inc.] |
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| February 22 – 24, 2024 Austin, Texas, United States |
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| University of Galway – Galway, Ireland, United Kingdom |
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| Karolinska Institutet – Solna, Sweden |
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| University of Alberta – Edmonton, Alberta, Canada |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| Francis Crick Institute – London, England, United Kingdom |
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