Mesenchymal Cell News Volume 16.03 | Jan 30 2024

    By
    Jamie Kang
    -
    0
    13







    2024-01-30 | MESCN 16.04


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.04 – 30 January, 2024
    TOP STORY

    Tricarboxylic Acid Cycle Metabolite-Coordinated Biohydrogels Augment Cranial Bone Regeneration through Neutrophil-Stimulated Mesenchymal Stem Cell Recruitment and Histone Acetylation-Mediated Osteogenesis

    The immune microenvironment- and MSC fate-regulated citrate-coordinated CGG hydrogels represented a highly efficient and facile approach toward skull bone tissue regeneration with great potential for bench-to-bedside translation.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Fructose Potentiates Bone Loss and Marrow Adipose Tissue Accumulation by Inhibiting Adenosine 5′-Monophosphate-Activated Protein Kinase in Mesenchymal Stem Cells

    Investigators identified fructose deteriorated bone mineral density while promoting the abundance of bone marrow adipose tissue. Fructose remarkably promoted the bone marrow MSCs adipogenic commitment at the expense of osteogenic commitment.
    [Stem Cells]

    Full Article
    Graphical Abstract

    Immortalized Chronic Myeloid Leukemia (CML) Derived Mesenchymal Stromal Cells (MSC) Line Retains the Immunomodulatory and Chemoprotective Properties of CML Patient-Derived MSCs

    Researchers generated and characterized an immortalized chronic myeloid leukemia (CML) patient-derived MSC line and assessed its role in leukemic stem cell maintenance.
    [Cellular Signalling]

    Abstract

    Immunological Effects of Human Decidual Mesenchymal Stem Cells in Spontaneous and Recurrent Abortions

    Scientists evaluated the immunological activities of human decidual MSCs on proliferation, apoptosis, and percentage of regulatory T cells in abortions and to investigate whether these activities differed in spontaneous abortions and recurrent abortions
    [Journal Of Reproductive Immunology]

    Abstract

    Efficient Induction of Pluripotent Stem Cells Differentiated into Mesenchymal Stem Cell Lineages

    Researchers employed a comprehensive methodology involving the differentiation of induced pluripotent stem cells into mesenchymal stem cells. The process was meticulously designed to ensure the expression of key MSC positive markers at elevated levels, coupled with the minimal expression of negative markers.
    [Journal Of The Chinese Medical Association]

    Abstract

    Gli1+ Periodontal Mesenchymal Stem Cells in Periodontitis

    Gli1 was used as a periodontal MSC marker and combined with a Gli1-cre ERT2 mouse model for lineage tracing to investigate periodontal MSC fate in an induced periodontitis model.
    [Journal Of Dental Research]

    Abstract

    Anti-Inflammatory Effect of Dental Pulpa Mesenchymal Stem Cell Exosomes Loaded Mucoadhesive Hydrogel on Mice with Dental Nickel Hypersensitivity

    Dental pulp MSCs were loaded to a mucoadhesive hydrogel based on chitosan, cross-linked with genipin, and modified with catechol groups. A dental nickel hypersensitivity model was created by administering NiCl2 and 10 μg/mL LPS to 4-6-week-old Balb-c mice by intradermal injection.
    [Macromolecular Bioscience]

    Abstract

    Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury

    Researchers explored the effect of exosomes derived from dental pulp stem cells (DPSC-Exos) on the regeneration of myelin sheaths in rats with sciatic nerve injury. In vitro and in vivo experiments were performed to clarify whether the effect of DPSC-Exos was associated with autophagy of Schwann cells.
    [Molecular Neurobiology]

    Abstract

    Effect of Human Umbilical Cord Blood-Mesenchymal Stem Cells on Cisplatin-Induced Nephrotoxicity in Rats

    To investigate the effect of human umbilical cord blood-MSCs on the histological structure, the oxidant stress, and the inflammatory gene expression in an experimental model of cisplatin-induced nephrotoxicity in rats.
    [Molecular Biology Reports]

    Abstract
    Automate your cell isolation with RoboSepâ„¢-S. Click to learn more.
    REVIEWS

    Current Status of Stem Cell Therapy for Type 1 Diabetes: A Critique and a Prospective Consideration

    Scientists identify the limitations that have to be overcome before stem cell therapy for diabetes becomes reliable and reproducible. As an alternative to cell therapy, the use of stem cell-derived extracellular vesicles is discussed as a future possibility.
    [Stem Cell Research & Therapy]

    Full Article

    Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential

    The authors focus on mitochondrial mechanistic insights in the whole life course of MSCs, as well as the potential roles played by mitochondria in MSCs treatment of transplantation, for seeking pivotal targets of stem cell fate regulation and stem cell therapy.
    [Stem Cell Reviews And Reports]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    BioCardia Doses First Patient in CardiALLO Phase I/II Clinical Trial of BCDA-03 Allogeneic Mesenchymal Stem Cells for the Treatment of Ischemic Heart Failure of Reduced Ejection Fraction

    BioCardia®, Inc. announced that the first patient was enrolled and treated in its CardiALLO™ Allogeneic Mesenchymal Cell Therapy Phase I/II trial for the treatment of patients with New York Heart Association Class II and III ischemic heart failure of reduced ejection fraction.
    [BioCardia®, Inc.]

    Press Release
    FEATURED EVENT

    2024 ACS Cancer Conference

    February 22 – 24, 2024
    Austin, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant- Type 2 Diabetes Mellitus-Induced Osteopathy

    University of Galway – Galway, Ireland, United Kingdom

    Research Assistant – Systems Biology of Adipose Tissue

    Karolinska Institutet – Solna, Sweden

    Assistant Professor – Stem Cell Biology in Rare Diseases

    University of Alberta – Edmonton, Alberta, Canada

    Research Assistant – Mammal Limb Regeneration

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Fellow – Regulation of Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2