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Vol. 16.09 – 12 March, 2024
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To improve the therapeutic efficiencies of MSCs in osteoarthritis treatment by carbonic anhydrase IX siRNA-based inflammation regulation and Kartogenin-based chondrogenic differentiation, the combination strategy of MSCs and the nanomedicine co-delivering KGN and siCA9 was used.
[ACS Nano]
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PUBLICATIONSRanked by the impact factor of the journal
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Flow cytometric analysis, RNA sequencing, and differentiation ability were applied to detect the characteristics of stromal cells from 3D human brain organoids.
[Stem Cell Research & Therapy]
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Human adipose tissue-derived MSCs were co-cultured with bone marrow-derived monocyte/macrophage from DBA/1J or B6 mouse in the presence of osteoclastogenic condition.
[Tissue Engineering And Regenerative Medicine]
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Network pharmacology was used to predict the targets of BZBS in delaying senescence in MSCs. For in vitro studies, MSCs were treated with D-gal, BZBS, and NMN, and cell viability, cell senescence, stemness-related genes, and cell cycle were studied.
[Heliyon]
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The authors differentiated iPSCs into iPericytes of either the mesoderm or neural crest lineage using established protocols.
[Current Stem Cell Research & Therapy]
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Investigators found a positive feedback cross-talk between senescent tendon stem cells (s-TSCs) and macrophages. The conditioned medium from s-STCs could promote macrophage polarization mainly toward the M1 phenotype, whose CM reciprocally accelerated further s-TSC senescence.
[Small]
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The authors differentiated iPSCs into iPericytes of either the mesoderm or neural crest lineage using established protocols.
[Clinical Cancer Research]
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Researchers investigated the anti-fibrogenic properties and mechanisms of the conditioned medium from human umbilical cord/placenta-derived MSCs in a murine intestinal fibrosis model and human primary intestinal myofibroblasts.
[Stem Cell Research & Therapy]
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Investigators describe characteristics and isolation methods of MSC-extracellular vesicles, and focus on their therapeutic potential describing its roles in tissue repair, anti-fibrosis, and cancer with an emphasis on the molecular mechanism and immune modulation and clinical trials.
[Life Sciences]
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Cellcolabs has raised $8.7 million from angel investors to expand production facilities and grow employee headcount. The Sweden-based company manufactures specialized stem cells that can be used to develop cell therapy treatments for diseases associated with inflammation.
[Sifted]
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April 22 – 25, 2024
Baltimore, Maryland, United States
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University of California, Davis – Sacramento, California, United States
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King’s College London – London, England, United Kingdom
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University of Sydney – Sydney, Australia
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UC Davis – Davis, California, United States
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BC Provincial Health Services Authority – Vancouver, British Columbia, Canada
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Cancer Stem Cell News
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