| Vol. 16.10 – 22 March, 2024 |
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| Researchers identified that the squamous cell carcinomas-master transcription factor TP63 suppressed interferon-γ signaling. TP63 inhibition led to increased CD8+ T cell infiltration and heightened tumor killing in in vivo syngeneic mouse model and ex vivo co-culture system, respectively. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the efficacy of cancer immunotherapies was compromised by the accumulation of senescent cells in mice and in the context of therapy-induced senescence [Nature Communications] |
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| To effectively target 4-1BB and treat diseases resistant to immune checkpoint inhibitors, scientists engineered ATG-101, a tetravalent “2+2” PD-L1×4-1BB bispecific antibody. ATG-101 bound PD-L1 and 4-1BB concurrently, with a greater affinity for PD-L1, and potently activated 4-1BB+ T cells. [Cancer Research] |
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| The authors identified that interleukin (IL)-1β signaling affects Inert naive CD4+ T (TN) cell characteristics, independent of tonic T cell receptor signaling, which also altered TN cell phenotypes. IL-1β reversibly attenuates the differentiation potential of TN cells toward Treg cells. [Cell Reports]
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| Scientists reported newly designed tripeptides that were able to trigger proinflammatory cytokine (IL-12 and IFN-γ) secretion by CD4+CD44+ T cells in response to Leishmania donovani infection. [Chemical Communications] |
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| Investigators explored whether interleukin-2/anti-interleukin-2 complex (IL-2C) alleviated lung inflammation in chronic obstructive pulmonary disease (COPD) by increasing the number of Tregs. [International Immunopharmacology] |
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| The authors investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a murine kidney transplant model of Ab-mediated rejection [Journal Of Immunology] |
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| Researchers identified 59 upregulated inflammation- and immune-related genes (IIRGs) in clear cell renal cell carcinoma from The Cancer Genome Atlas database. [Human Cell] |
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| Scientists investigated the impact of enterovirus 71 (EV71) on plasmacytoid dendritic cells (pDCs) and CD4+ T cells. The results showed that pDCs were promptly activated, secreting interferon (IFN)-α and inducing CD4+ T cell proliferation and differentiation during early EV71 infection. [Archives Of Virology] |
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| Investigators discuss advances in the understanding of mucosal T cell immunity during chronic viral infections and how features of T cell responses develop in different chronic viral infections of the mucosa. [Cellular & Molecular Immunology] |
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| The authors discuss the double roles of T cells in metabolic dysfunction–associated steatotic liver disease (MASLD) from the perspective of T cell response pathways, as well as new evidence regarding the possible application of immunomodulatory therapy in metabolic dysfunction-associated steatohepatitis. [Biomedicine & Pharmacotherapy] |
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| Eledon Pharmaceuticals, Inc. announced that the company’s investigational anti-CD40L antibody, was used as a component of the immunosuppressive treatment regimen following the first-ever transplant of a kidney from a genetically modified pig to a human. [Eledon Pharmaceuticals, Inc.] |
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| April 17 – 20, 2024 Rotterdam, Netherlands |
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| Vanderbilt University – Bethesda, Maryland, United States |
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| NYU Langone Health – New York City, New York, United States |
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| Universitätsklinikum Köln – Cologne, Germany |
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| University of Oslo – Oslo, Norway |
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| Francis Crick Institute – London, England, United Kingdom |
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