Modeling Parkinson’s Disease Pathology in Human Dopaminergic Neurons by Sequential Exposure to α-Synuclein Fibrils and Proinflammatory Cytokines

Scientists found that induced pluripotent stem cell-derived human dopaminergic neurons form lewy body-like inclusions after treatment with α-synuclein preformed fibrils but only when coupled to a model of immune challenge or when co-cultured with activated microglia-like cells.