Enhancing RNA Base Editing on Mammalian Transcripts with Small Nuclear RNAs

Compared with adenosine deaminase acting on RNA (ADAR)-recruiting circular RNAs, researchers found that guided A>I snRNAs consistently increase adenosine-to-inosine editing for higher exon count genes, perturb substantially fewer off-target genes, and localize more persistently to the nucleus where ADAR is expressed.