Newsletters

[Signal Transduction and Targeted Therapy] Investigators performed a comprehensive preclinical comparison of conventional CAR-T cells and allogeneic stem cell–derived IL-15–enhanced CAR-NKT cells in solid tumor models, integrating spatiotemporal transcriptomic profiling across multiple tissues and longitudinal time points.

[Science Advances] The authors demonstrated that HCW9206, a unique protein scaffold linking interleukin-7 (IL-7), an IL-15/IL-15 receptor α complex, and IL-21, generates CAR T cells without requiring αCD3/28 activation, which are highly enriched in long-lived T memory stem cells and display potent activity across distinct disease models, HIV-1 or B cell leukemia.

[Molecular Therapy] Investigators implemented a feeder-free, scalable approach for ex vivo manufacture of polyclonal, non-virally modified, gene-edited CAR-γδ T cells for therapeutic application.

[Journal of Neuro-Oncology] Scientists reposition GBM CAR T-cell therapy as a systems-level issue, turning localized CAR T cell cytotoxicity into sustained control of the disease by engaging endogenous antitumor immunity via cytokine myeloid chemokine networks.

[European Journal of Medical Research] Researchers investigated how monocarboxylate transporters (MCT) 1 inhibition modulates Treg metabolism and function, and the potential implications for tumor immunotherapy.

[Journal for Immunotherapy of Cancer] In both patient-derived samples and mouse models, CD44 blockade reduces Treg abundance, restores cytotoxic T cell activity, and enhances the therapeutic response to anti-PD-1 treatment.

[FEBS Journal] Scientists conducted single-cell transcriptomic and immunophenotypic analyses of liver- and spleen-derived Tregs from neonatal and adult mice.

[Nature Communications] The Src family kinase Lyn is known to be involved in the induction and maintenance of peripheral B cell tolerance. Scientists utilized a system in which Lyn deletion is tamoxifen inducible and B cell restricted, which allows acute elimination of Lyn in B cells only, minimizing confounding factors.

[Oncoimmunology] The authors underscore a dual role for B cells in melanoma, supporting antitumor immunity or promoting immune escape, and highlight opportunities to target regulatory B cells, correct isotype imbalance, and leverage B cell signatures as biomarkers.

[Science Immunology] Researchers found that epitopes derived from seed storage proteins are targets of murine intestinal Treg cells, with the most frequent response targeting the C terminus of the maize protein alpha-zein.

[Genes and Immunity] Scientists provide a comprehensive analysis of the immune imbalance of allergic rhinitis, focusing on the key role of Th17/Treg cell imbalance in the pathogenesis of diseases.

[Mbio] Using the intestinal mucosa as a paradigm, scientists explore how the gut microenvironment fosters the generation of tolerogenic antigen-presenting cells and microbe-specific Tregs to enforce immunological tolerance.