Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progression of Breast Cancer

Using single-cell transcriptomic analysis and in situ profiling of primary tumors, metastases, and circulating tumor cells from multiple patients with breast cancer, investigators’ identified a unique EPCAM⁺ CD68⁺ TREM2⁺ tumor subpopulation.