[Journal of Clinical Investigation] Given that synovial sarcoma is characterized by a peculiarly low DNA hypomethylation profile, researchers hypothesized that further disturbance of DNA methylation would have a negative impact on synovial sarcoma growth.

[Trends in Cancer] Scientists discuss the role of the ECM in driving cancer aggression through its impact on tumor heterogeneity.

[Cell Reports] Scientists showed that SLNCR binds to E2F1 to promote the proliferation, invasion, and migration of melanoma cells from the bloodstream into the lungs.

[Leukemia] This real-life study compared mutation profiles and their impact on outcomes in 80 adolescent and young adults, 97 adult, and 16 pediatric chronic myeloid leukemia in chronic phase patients, alongside 81 BCR::ABL1-positive acute lymphoblastic leukemia patients.

[Cell Reports] Scientists demonstrated that CD248⁺ universal fibroblasts from the lung and colon outside the skeletal system generated CXCL12-abundant reticular/leptin-receptor-expressing cells characterized by HSC niche functions.

[Scientific Reports] Researchers investigated the effect of bone MSCs in intervertebral disc degeneration (IVDD) by magnetic resonance imaging and hematoxylin and eosin staining analysis using a rat-punctured IVDD model.

[Leukemia] Investigators proposed that the complosome, like its role in lymphocytes, is necessary for the optimal function of mitochondria in hematopoietic cells, including hematopoietic stem progenitor cells.

[Experimental Cell Research] The authors explore different subtypes of cancer-associated fibroblasts, their origins, and how they have evolved in their pro-tumorigenic roles in melanoma.

Investigators identified the tumor cell-expressed paired immunoglobulin-like type 2 receptor alpha (PILRα) as an immune suppressor targeting T cells using high-throughput screening. [Nature Cancer] Abstract

[Circulation] Scientists examined whether CD206⁺ macrophages expressing interleukin (IL)–4Rα are key drivers of adverse left ventricular remodeling in heart failure.

[Cancer Discovery] Single-cell profiling revealed responders had higher baseline intratumoral CD8⁺ T cells with a tumor-reactive, tissue-resident memory phenotype and a treatment-related decrease in effector regulatory T cells.

[ACS Nano ] In vivo analyses demonstrated the efficient uptake of PLN-GR by antigen-presenting cells, particularly Kupffer cells and splenic dendritic cells, driving their tolerogenic phenotypic transformation.