[Cell Reports Medicine] Researchers showed that H₂S, an endogenous gas signaling molecule, sensitizes breast cancer to chemotherapy by suppressing STAT3 signaling-mediated lipid metabolism and improves tumor immunogenicity.

[Nature Cell Biology] An unbiased genome-scale genetic screen identified Med4 as a cancer cell-intrinsic gatekeeper in metastatic reactivation. Correspondingly, MED4 haploinsufficiency was found to be prevalent in metastatic breast cancer and associated with poorer clinical outcomes.

[Nature Communications] Investigators used comprehensive multi-omics profiling of TNBC. They reported that extracellular matrix (ECM) immunomodulation in TNBC is mediated by post-translational glycan modifications on ECM proteins.

[Nature Communications] Scientists showed, across HER2+ transgenic mouse models the oncogenic HER2 splice variant lacking exon 16 (HER2∆16) promotes the development of aggressive luminal tumors by facilitating an estrogen receptor-mediated transcriptional program which is sensitive to endocrine therapies.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers generated estrogen receptor (ER)-positive breast cancer models that closely mimic the human disease in histology, hormone responsiveness, and the immune microenvironment.

[Cell Death & Disease] Investigators identified that the loss of the polarity protein MALS3 disrupts the homeostasis of mammary epithelial cells while increasing breast cancer stem cell-like properties.

[NPJ Precision Oncology] The authors summarized the current progress on the molecular mechanism underlying the function of nucleic sexual hormone receptors in breast cancer (BCa), providing insights for the novel therapeutic strategies in BCa.

[Hexagon Bio] Hexagon Bio announced the formation of a clinical advisory board (CAB) consisting of leading experts in the treatment and investigation of new therapies for breast cancer. CAB members will provide strategic guidance as the company advances its lead development candidate, HEX-360, toward first-in-human study.

[Oligomerix, Inc. (Business Wire)] Oligomerix, Inc. announced an National Institutes of Health (NIH) Fast Track Phase II award of $1.9 million from the National Institute on Aging of the NIH.

[Nature] Researchers found that neurons routinely sustain DNA breaks during cortex formation, but a rapid repair system corrects the damage before harm occurs.

[Autophagy] Using integrated transcriptomic and epigenomic analyses, scientists identified EGR1 as a critical regulator of traumatic brain injury pathology, with its expression acutely upregulated in neurons post-injury.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators identified embigin (EMB) as a critical regulator of enteric neuronal maturation. In EMB mutant patients, the expression of EMB is reduced in the enteric neurons of the hypoganglionosis-affected colon.