Keep Current with the Latest in Cell Biology Research

Donor Embryonic Stem Cells Displace Host Cells of 8-Cell-Stage Chimeras to the Extra-Embryonic Lineages by Spatial Crowding and FGF4 Signaling

[Development] The authors combined chimera titration assays with mathematical modelling to study mechanisms of host cell displacement.

Interaction of Cardiomyocytes from CCND2-Overexpressing Human Induced Pluripotent Stem Cells with Electrically Conductive Hydrogels

[RSC Advances] Researchers developed a gold nanorod-embedded gelatin-methacrylate hydrogel scaffold seeded with hiPSC-cardiomyocytes and hiPSC-derived cardiac fibroblasts

Nat10 Maintains the Homeostasis of Pluripotent and 2-Cell-Like States in Mouse Embryonic Stem Cells through mRNA Cytidine Acetylation

[Nucleic Acids Research] Investigators showed that N-acetyltransferase 10 (Nat10) maintains the pluripotent state and suppresses the 2C-like state in mESCs through mRNA modification and stabilization.

KIAA1522 Isoform Switching Regulates LTR-RTs Activity in Distinct Pluripotency States of hESCs

[Science China Life Sciences] Scientists performed RNA sequencing and identified differential alternative splicing events in 784 genes between naïve and primed hESCs.

E-Cadherin Negatively Regulates hESCs Endodermal Differentiation under Varied Substrate Stiffnesses

[Cellular and Molecular Life Sciences] An in vitro model was used to elucidate the effects of E-cadherin complexes on definitive endoderm-directed differentiation of hESCs, when the cells were seeded on polyacrylamide hydrogels with varied stiffnesses.

CHD7 Regulates Definitive Endodermal and Mesodermal Development from Human Embryonic Stem Cells

[Stem Cell Research & Therapy] Researchers used CRISPR/Cas9 technique to delete the CHD7 gene in hESCs to generate CHD7 homozygous mutant, heterozygous mutant, and control wild-type cells.

ALS TDI Announces New Agreement with Axol Bioscience to Expand Access to ALS Patient iPSC-Derived Cells for Global Research

[ALS Therapy Development Institute (ALS TDI)] The ALS Therapy Development Institute (ALS TDI) announced that a collection of cells derived from ALS patient-derived iPSC lines will now be made widely available to researchers around the world.

Elimination of Tumorigenic Pluripotent Stem Cells from Their Differentiated Cell Therapy Products: An Important Step toward Ensuring Safe Cell Therapy

[Stem Cell Reports] Investigators summarize current strategies to eliminate tumorigenic hPSCs, most of which target hPSC-specific markers, and critically evaluate the advantages and limitations of each approach.

Integrin β1 Activity Controls Colony Morphology during Human Pluripotent Stem Cell State Transitions

[Stem Cell Reports] Scientists investigated the role of integrin β1 in regulating naive-like and primed hiPSC states. They found that integrin β1 is active in both in vitro.

Stem Cell Derived Exosome Trilogy: An Epic Comparison of Human MSCs, ESCs, and iPSCs

[Stem Cell Research & Therapy] The advantages and disadvantages of using exosomes isolated from hESCs, hiPSCs), human mesenchymal stem cells (hMSCs) for therapeutic applications are further discussed in this review.

Cell State-Specific Cytoplasmic Density Controls Spindle Architecture and Scaling

[Nature Cell Biology] Scientists showed that cell state-specific cytoplasmic density tunes mitotic spindle architecture. They revealed physical properties of the cytoplasm as a major determinant in organelle size control.

RIFINs Displayed on Malaria-Infected Erythrocytes Bind KIR2DL1 and KIR2DS1.

[Nature] Researchers demonstrated that activating killer immunoglobulin-like receptors can recruit natural killer cells to target a pathogen and revealed a potential role for activating immune receptors in controlling malaria infection.

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