[Cell Reports] Exposing brain organoids to serum induces apical-out orientation. Lysophosphatidic acid, present in the medium of prior apical-out techniques, was identified as the causative factor.

[Journal of The American Heart Association] Chromatin immunoprecipitation‐sequencing was integrated with RNA sequencing to identify super‐enhancer‐regulated target genes in hypoxic pulmonary arterial smooth muscle cells.

[Stem Cell Reports] The authors used hiPSC-derived cortical and ganglionic eminence organoids to examine APOE4’s influence during the development of cortical excitatory and inhibitory neurons.

[Stem Cell Reports] Investigators reported a co-culture system employing patient-derived glioblastoma organoids and hiPSC-derived cholinergic neurons.

[Small Methods] Readout on a single-cell level can be realized via fluorescence-based flow cytometry at the cost of tissue dissociation and loss of spatial information.

[Biological Procedures Online] The authors established a mouse lung cancer organoid model derived from a genetically engineered mouse model that can spontaneously develop lung cancer.

[Trends in Biotechnology] Scientists present an overview of the key design blueprints for generating innervated tissue models, highlight the challenges to be overcome, and discuss the biomedical breakthroughs that can branch from such in vitro platforms.

[Cell Stem Cell] Investigators presented a streamlined method to generate vascular organoids from iPSCs via orthogonal activation of the transcription factors ETV2 and NKX3.1 using Dox-inducible or modRNA systems.

[Nature Genetics] The authors combined large-scale Shigella infections of enteroids and colonoids with transposon-directed insertion sequencing and Bayesian statistical modeling to address infection bottlenecks.

[Samsung Biologics] Samsung Biologics announced the launch of Samsung Organoids – advanced drug screening services to support clients in drug discovery and development.

[Molecular cancer] Researchers reported that CREPT/RPRD1B, which exhibits somatic gene copy-number amplifications and elevated expression, correlated with poor patient survival and drives TNBC metastasis.

[Experimental Hematology & Oncology] Scientists offered innovative perspectives on comprehending the heterogeneity within the TME of TNBC, thereby facilitating the elucidation of TNBC biology and providing clinical recommendations for TNBC patients' prognosis, such as IL32^high Treg infiltration, Malignant Cell Index evaluation, and UQCRFS1 expression.