[Oncogenesis] Researchers revealed a novel HPV16 E7-APC2-SPIN4 axis as a key driver of cervical cancer. In this pathway, APC2 unexpectedly functions as an oncogene by activating the Wnt/β-catenin signaling to promote tumorigenesis and CSC properties.

[Biomaterials] Scientists presented a polyelectrolyte multilayer-based surface coating designed to promote rapid spheroid formation from individual cancer cells.

[Proceedings of The National Academy of Sciences of The United States of America] While scientists showed a strong molecular resemblance between Aging-luminal progenitors (ALPs) in aged normal tissue and ALP-like cancer cells, proving that ALPs are the normal cell-of-origin of ALP-like tumors remains to be established by future lineage-tracing experiments.

[BMC Medicine] The expression of CSC markers CD44 and ALDH1A1 under treatment conditions was analyzed using immunohistochemistry and flow cytometry.

[Journal of the American College of Surgeons] Activating Notch1 signaling in melanoma-associated fibroblasts overcomes BRAF inhibitor resistance by disrupting cancer stem cell niches.

[Blackstone Life Sciences] Blackstone Life Sciences announced a research and development funding agreement to advance the clinical development of bleximenib (JNJ-75276617), an investigational oral menin inhibitor, for AML.

[Nature Communications] The authors showed that newly specified hematopoietic stem and progenitor cells (HSPCs) achieve this unique state by precise spatio-temporal regulation of reactive oxygen species via Bnip3lb-associated developmentally-programmed mitophagy, a distinct autophagic regulatory mechanism from that of adult HSPCs.

[Biomaterials] Investigators presented a porous microscaffold that enables robust hematopoietic differentiation from human pluripotent stem cell-derived mesoderm.

[Leukemia] Using mouse models and primary human samples, researchers investigated the impact of SRSF2 mutations on erythropoiesis. They found reduced erythropoiesis in Srsf2^P95H versus wild-type mice upon stress-induced erythropoiesis.

[Blood Advances] To explore the regulation of erythropoiesis in the bone marrow in response to anemia, investigators studied the role of E-cadherin in the erythroid lineage of rats.

[FASEB Journal] Researchers showed that GATA1 forms dynamic nuclear condensates in HEK293T, HUDEP2 progenitors, and erythroleukemia cells, as well as concentration-dependent droplets in vitro.

[Blood] Investigators demonstrated that AML cells upregulate the peroxisomal very-long-chain fatty acid transporter ABCD1 and increase endogenous levels of peroxisomal fatty acid oxidation relative to healthy hematopoietic cells.