[European Journal of Medical Research] Researchers investigated how monocarboxylate transporters (MCT) 1 inhibition modulates Treg metabolism and function, and the potential implications for tumor immunotherapy.

[Journal for Immunotherapy of Cancer] In both patient-derived samples and mouse models, CD44 blockade reduces Treg abundance, restores cytotoxic T cell activity, and enhances the therapeutic response to anti-PD-1 treatment.

[FEBS Journal] Scientists conducted single-cell transcriptomic and immunophenotypic analyses of liver- and spleen-derived Tregs from neonatal and adult mice.

[Nature Communications] The Src family kinase Lyn is known to be involved in the induction and maintenance of peripheral B cell tolerance. Scientists utilized a system in which Lyn deletion is tamoxifen inducible and B cell restricted, which allows acute elimination of Lyn in B cells only, minimizing confounding factors.

[Oncoimmunology] The authors underscore a dual role for B cells in melanoma, supporting antitumor immunity or promoting immune escape, and highlight opportunities to target regulatory B cells, correct isotype imbalance, and leverage B cell signatures as biomarkers.

[Science Immunology] Researchers found that epitopes derived from seed storage proteins are targets of murine intestinal Treg cells, with the most frequent response targeting the C terminus of the maize protein alpha-zein.

[Genes and Immunity] Scientists provide a comprehensive analysis of the immune imbalance of allergic rhinitis, focusing on the key role of Th17/Treg cell imbalance in the pathogenesis of diseases.

[Mbio] Using the intestinal mucosa as a paradigm, scientists explore how the gut microenvironment fosters the generation of tolerogenic antigen-presenting cells and microbe-specific Tregs to enforce immunological tolerance.

[Nature Medicine] The authors highlight insights from recent clinical trials, translational studies and preclinical models, which reveal critical factors for optimizing cancer vaccines.

[Nature] Scientists show that newborn babies with E. coli sepsis have selectively reduced vertically transferred natural antibodies that recognize E. coli sepsis, mechanistically explaining their susceptibility to infection.

[Nature Reviews Genetics] Advances in targeted delivery — using viral vectors, mRNA-loaded nanoparticles and virus-like particles — are expanding the toolkit for direct programming of cells within the body.

[Blood Advances] Scientists evaluated human-specific CCR4-directed CARTs previously developed for T cell malignancies and determined whether these CARTs could deplete human Tregs ex vivo and in vivo.