[Communications Biology] Scientists demonstrated that suppress of cholesterol synthases FDFT1 or SQLE enhances colorectal cancer metastasis and stemness through impairing ER stress and degrading PDIA4 or SYVN1 individually.

[Cell Death & Disease] Researchers identified a noncanonical, nuclear role of hexokinase 2 that couples systemic hyperglycemia to MYC-driven glycolysis and stemness in bladder cancer.

[Oncogene] Investigators reported that PKM2 expression is upregulated in breast CSCs (BCSCs). LINC00887 maintains the self-renewal of BCSCs by promoting PKM2 splicing and reprogramming glucose metabolism.

[NPJ Breast Cancer] Scientists investigated progesterone receptor-dependent transcriptional programs such as the unfolded protein response that can be leveraged to target CSCs in Y537S estrogen receptor gene (ESR1)-mutant breast cancer.

[Proceedings of the National Academy of Sciences of the United States of America] Using a clinically relevant closed-head weight-drop mouse model, scientists identified mtDNA-specific damage and increased expression of innate inflammatory markers in the cerebral cortex during the acute mild traumatic brain injury phase.

[Science Signaling] Researchers found that the neurotrophin brain-derived neurotrophic factor amplifies multiple neuron-intrinsic programs to foster axonal regeneration in human iPSC-derived lower motor neurons.

[Communications Biology] The authors introduced a higher-order model of the tripartite synapse, accounting for astrocyte-synapse-neuron interactions in short-term plasticity, such that astrocyte gliotransmission and pre-synaptic facilitation jointly modulate neurotransmitter release, generalizing earlier short-term plasticity models.

[Molecular Cancer Therapeutics] Scientists generated three distinct glioma stem cell lines from high-grade gliomas arising in mice with Nf1 and Trp53 mutations in cis and characterized the allografts resulting from one Nf1-glioma stem cell line by single cell and single nuclear RNA-seq.

[Molecular Cancer Therapeutics] Researchers generated three inducible CRISPR inhibition cell lines to deplete activated leukocyte cell adhesion molecule (ALCAM) and elucidate its role in neuroblastoma.

[Scientific Reports] To define the therapeutic relevance of PCSK9 inhibition in Alzheimer’s disease-like pathology, scientists examined SBC-115,076 in AlCl₃-challenged zebrafish larvae and mechanistically validated its effects using complementary endothelial–microglial in vitro models.

[Nature Reviews Endocrinology] The authors synthesize the current understanding of vasomotor symptoms neurobiological pathways, examines translational approaches from preclinical animal models to clinical studies, and discusses the evolution of treatments and mechanism-based interventions.

[Keck School of Medicine of USC] A team of researchers at the University of Southern California (USC) Mark and Mary Stevens Neuroimaging and Informatics Institute at the Keck School of Medicine of USC has received a major grant from the National Institutes of Health (NIH) to investigate a long-standing mystery in Alzheimer’s disease.