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Autocrine SFRP2 (Secreted Frizzled Related Protein 2) Enhances Lung Myofibroblast Fibrogenic Activity by Suppressing PINK1-Mediated Mitophagy Initiation
[Autophagy] Using single-cell RNA sequencing, researchers identified SFRP2 as a critical mediator of profibrotic myofibroblasts in idiopathic pulmonary fibrosis lungs.
E2A Selectively Regulates TGF-β-Induced Apoptosis in KRAS-Mutant Non-Small Cell Lung Cancer
[Molecular Oncology] Investigators identified the transcription factor E2A as a critical mediator of resistance to transforming growth factor-β (TGF-β)-induced apoptosis in mutant KRAS–driven NSCLC.
TNIK Overexpression Is Sufficient for Chemoradiation Resistance in Limited-Stage Small Cell Lung Cancer
[Molecular Cancer Therapeutics] Researchers used patient-derived xenografts to model small cell lung cancer chemoradiation resistance and identified chemoradiation resistance candidate genes using RNA sequencing.
The Combined Inhibitory Effect of Butaselen and Decitabine against Lung Cancer Cells
[Scientific Reports] Scientists investigated the combined effects of the thioredoxin reductase inhibitor butaselen and decitabine on lung cancer cells in vitro.
TRIM3 Suppresses Tumor Progression in Non-Small-Cell Lung Cancer by Promoting PD-L1 Ubiquitination and Degradation
[Annals of Surgical Oncology] The authors investigated TRIM3 expression and its role in the immune microenvironment of NSCLC. TRIM3 levels in NSCLC tissues and cells were detected by reverse transcriptase quantitative polymerase chain reaction.
Trigonelline Suppresses the Tumor Progression via STAT2 Signalling Pathway in Non-Small Cell Lung Carcinoma
[Medical Oncology] Researchers investigated its therapeutic efficacy against A549 lung cancer cells and elucidates the underlying molecular mechanisms.
Targeting the Epithelium in Pulmonary Fibrosis
[European Respiratory Review] Scientists epithelial populations, identified and validated through cutting-edge technologies, may provide targets for the next wave of therapeutics for patients with idiopathic pulmonary fibrosis.
MicroRNA-Regulated Signaling and Tumor Microenvironment Modulation in Lung Cancer: Mechanistic Insights and Translational Opportunities
[Cancer Cell International] By providing insights into the molecular functions of miRNAs, investigators elucidate the promising prospects of miRNAs as biomarkers for early diagnosis and targets for novel therapeutic strategies in lung cancer.
CD8+ T Cells Sustain Vaccination-Induced Immunity against Dissemination of Contained Tuberculosis in Immunosuppressed Hosts
[Nature Communications] Scientists showed that immunosuppression-induced dissemination of lymphatic Mycobacterium tuberculosis and ensuing progressive disease can be prevented by vaccination with BCG or recombinant BCG even in the absence of CD4+ T cells.
A New mRNA Antigen Vaccine Induces Potent B and T Cell Responses and In Vivo Protection against SARS-CoV-2
[NPJ Vaccines] Scientists added new T cell epitopes to the receptor-binding domain RBD mRNA vaccine and identified a SARS-CoV-2 membrane epitope that significantly improved vaccine-induced immunity and protection in vivo.
CD4+ T Cell-Mediated Immunity Protects from VSV-SUD Lethal Challenge in a Mouse Model of Sudan Virus Infection
[Nature Immunology] To unravel mechanisms contributing to protection, researchers used a surrogate mouse model of Sudan virus infection amenable to deep functional analysis.
Host Macrophages/Monocytes Promote Malaria Transmission by Modulating Mosquito Microbiota via SR-a-Mediated Phagocytosis
[Nature Communications] Researchers demonstrated that macrophages/monocytes—rather than neutrophils or NK/NKT cells—play a crucial role in enhancing malaria transmission to mosquitoes, both in rodent models and human.
