[Biomaterials Science] Scientists discuss emerging biomaterials strategies that leverage tunable biomaterial properties to disrupt key metabolic, transcriptional, and signaling pathways central to Treg-mediated immunosuppression in cancer.

[Immunology] The authors synthesize knowledge on medullary thymic epithelial cell biology, Aire- and Fezf2-dependent transcriptional programs, and advances in immunopeptidomics.

[Science Advances] Investigators demonstrated that plasmacytoid dendritic cells (pDCs) in the thymus have two distinct subsets, accumulating in the thymus of tumor-bearing mice, contributing to immune tolerance through clonal deletion of tumor-specific T cells and reducing newly generated T cells.

[Journal of Clinical Investigation] Researchers identified the sterol regulatory element–binding protein 1c (SREBP1c) as a central regulator of Treg immunobiology. Tregs from Srebp1c-deficient mice displayed impaired suppressive function, reduced frequencies in circulation and lymphoid tissues, and diminished expression of functional markers.

[Kidney International] Patients who achieve operational tolerance after kidney transplantation, maintaining stable graft function without immunosuppression, exhibit enrichment of specific Treg subsets, supporting a direct association between Tregs and allograft tolerance.

[Immunity] Investigators examined the relative importance of T cell receptor (TCR) recognition vs. environmental cues, leveraging CRISPR-based TCR editing of primary T cells with a large TCR panel, assessing p eripheral differentiation of regulatory T (pTreg) cell differentiation induced by self-, microbial, or dietary antigens.

[Monash University] Monash University researchers will share in $50.5 million through the latest round of National Health and Medical Research Council (NHMRC) Investigator Grants, with 28 awards across four faculties. The successful projects span areas including perioperative clinical trials, molecular biology, and the integration of artificial intelligence.

[LFA] The Lupus Foundation of America (LFA) announced its 2026 Pediatric Lupus Research Grant to Dr. Holly Wobma. Dr. Wobma will be studying CAR-Treg's capacity to restore immune balance and subsequent disease remission in children with lupus.

[Autophagy] Scientists confirmed that chaperone-mediated autophagy (CMA) is a fundamental mechanism supporting Treg suppressive function as CMA-deficient Tregs are unable to suppress intestinal inflammation in a model of inflammatory bowel disease and fail to block the anti-oncogenic immune response activated in a syngeneic tumor model.

[Nature Communications] Investigators demonstrated that oral administration of the gut microbiota metabolite butyrate induces sustained IL-10 production in CD4⁺ T cells, conferring long-lasting protection against intestinal inflammation even after treatment withdrawal.

[American Journal of Respiratory and Critical Care Medicine] Investigators characterized the role of ADAM with Thrombospondin motifs 14 (ADAMTS14) in YAP-mediated fibroblast mechanoactivation and pulmonary fibrosis.

[Signal Transduction and Targeted Therapy] In this study, digital spatial profiling, multiplex immunofluorescence, and clinical data from 52 lung adenocarcinoma patients were integrated to develop organ-specific metastasis risk models, and the molecular mechanisms underlying metastatic organotropism were investigated.