[Cancer Cell] The authors showed that in colorectal cancer, cholinergic stimulation induces CHRM3/Gq-dependent NTN1 secretion from cancer-associated fibroblasts, which in turn enhances intratumor cholinergic innervation.

[Cell Metabolism] Researchers showed that the canonical anti-ferroptosis response mediated by GPX4 and SLC7A11 is dispensable for colorectal cancer growth and progression in both sporadic and colitis-associated cancer models.

[Nature Metabolism] Scientists demonstrated in a range of colorectal cancer models that 5-fluorouracil treatment promotes mitochondrial biogenesis and increases mitochondrial function in surviving cells.

[Nature Communications] Investigators showed that a high-fat diet and fecal microbiota from patients with obesity-associated colorectal cancer deplete the GABA-producing commensal Bacteroides ovatus, resulting in reduced luminal GABA and accelerated tumorigenesis.

[EMBO Molecular Medicine] Researchers identified RADX, a structural antagonist to RAD51 and a key regulator of replication fork stability, as a critical suppressor of intestinal inflammation by limiting innate immune sensing of replication-associated DNA damage.

[Cellular Signalling] Scientists assessed the impact of TBX1 on the proliferation and colony-forming capacity of colorectal cancer cells, and carried out in vitro functional investigations.

[Molecular Immunology] Investigators founds that the overexpression of Mitofusin-2 (MFN2) suppressed colorectal cancer cell glycolysis and tumor growth by enhancing TRIM21-mediated degradation of PFKP.

[Biochemical Pharmacology] The authors highlight how interactions within the colorectal tumor microenvironment drive metastasis, immune evasion, and therapy resistance, revealing new opportunities for combination cancer therapies.

[Dispatch Bio] Dispatch Bio announced the first participant has been dosed in a Phase I clinical trial evaluating the safety and efficacy of DISP-10 in adult participants with advanced gastrointestinal (GI) cancers,

[Cell Stem Cell] Researchers established Cardiopedia-Ligand, a comprehensive perturbation-function-transcriptome atlas generated by stimulating human cardiac organoids with 87 ligands targeting 98 cell-membrane receptors expressed in the human heart.

[Emerging Microbes & Infections] Investigators established long-term expanding three-dimensional porcine airway organoids as a platform for the phenotypic and transcriptomic characterization of reassortant influenza viruses.

[Science Advances] Scientists developed vascularized liver organoids by integrating hiPSC–derived hepatoblasts and endothelial cells into decellularized scaffolds functionalized with an anti-CD31 aptamer–based vascular coating agent.