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lbeveridge

Comparative Efficacy and Safety of Prostatic Urethral Lift versus Prostatic Artery Embolisation for Benign Prostatic Hyperplasia: A Systematic Review and Network Meta-Analysis

[BJU International] Scientists assess and compare the clinical efficacy and safety of prostatic urethral lift and prostatic artery 2mbolization for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.

L-Nutra Reports Initial Data Showing Improvements in Metabolic Risk Factors in Patients with Prostate Cancer

[L-Nutra, Inc. (Businesswire, Inc.)] L-Nutra Inc. announced data from a first-of-its-kind study evaluating the impact of its Fasting Mimicking Technology on metabolic risk factors in patients with prostate cancer.

Protective Role of MicroRNA-23a/B-3p Inhibition against Osteoarthritis through Gremlin1-Depenent Activation of TGF-β/Smad Signaling in Chondrocytesa

[Inflammopharmacology] Researchers explored effect of miR-23a/b-3p on OA in regulating chondrocyte growth. The medial meniscus and anterior cruciate ligaments of right knee was removed to induce a mouse model of OA.

Grem1 Accelerates Nucleus Pulposus Cell Apoptosis and Intervertebral Disc Degeneration by Inhibiting TGF-β-Mediated Smad2/3 Phosphorylation

[Experimental & Molecular Medicine] The regulatory effects of Gremlin-1 on apoptosis were examined using siRNAs, flow cytometry, immunofluorescence, and western blotting.

Effects of Ivacaftor on Systemic Inflammation and the Plasma Proteome in People with CF and G551D

[Journal of Cystic Fibrosis] Scientists investigated the biology of cystic fibrosis transmembrane conductance regulator (CFTR) modulation and systemic effects of CFTR restoration by examining changes in circulating measurements of inflammation and growth and novel proteins with ivacaftor treatment.

UHRF1 Establishes Crosstalk between Somatic and Germ Cells in Male Reproduction

[Cell Death & Disease] The authors reported that UHRF1, a critical epigenetic regulator, was mainly expressed in human and mouse pre-mature SCs, and is essential for establishing Sertoli-Germ cell crosstalk.

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Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.