Noshin Noorjahan

Endothelial Cell News

Aulos Bioscience Announces FDA Clearance of IND Application for AU-007, a Novel Immunotherapy for the Treatment of Solid Tumors

[Aulos Bioscience] Aulos Bioscience announced that the US FDA has cleared its Investigational New Drug application for AU-007, a monoclonal antibody computationally designed by Biolojic Design.

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Arglabin, an EGFR Receptor Tyrosine Kinase Inhibitor, Suppresses Proliferation and Induces Apoptosis in Prostate Cancer Cells

[Biomedicine & Pharmacotherapy] Arglabin, a sesquiterpene lactone isolated from Artemisia glabella, was cytotoxic to different human cancer cell lines including those derived from advanced triple-negative breast, lung, and androgen-dependent and androgen-independent prostate carcinomas.

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A Cryptic Transactivation Domain of EZH2 Binds AR and AR’s Splice Variant, Promoting Oncogene Activation, and Tumorous Transformation

[Nucleic Acids Research] Scientists reported that a cryptic transactivation domain of EZH2 binds both androgen receptor (AR) and AR spliced variant 7 mediating assembly and/or recruitment of transactivation-related machineries at genomic sites that lack polycomb repressive complex 2 binding.

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PSMA1-Mediated Ultrasmall Gold Nanoparticles Facilitate Tumor Targeting and MR/CT/NIRF Multimodal Detection of Early-Stage Prostate Cancer

[Nanomedicine: Nanotechnology, Biology and Medicine] Investigators devised a multimodal contrast agent that featured highly-effective PSMA targeting and desired molecular pharmacokinetics for prostate cancer diagnosis.

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Knockdown of USP8 Inhibits Prostate Cancer Cell Growth, Proliferation, and Metastasis and Promotes Docetaxel’s Activity by Suppressing the NF-kB Signaling Pathway

[Frontiers in Oncology] Prostate cancer cell lines DU145 and PC3 were transfected with ubiquitin-specific protease 8 siRNA or overexpressing vector together with or without docetaxel.

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Juglone Promotes Antitumor Activity against Prostate Cancer via Suppressing Glycolysis and Oxidative Phosphorylation

[Phytotherapy Research] Researchers investigated the effect of juglone on energy metabolism in prostate cancer cells and found that juglone inhibited cell proliferation and induced apoptosis.

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Aberrant PJA2-CHRM3 Signaling Creates a Therapeutic Vulnerability in Gastric Tumor

[British Journal of Cancer] Scientists constructed mouse gastric organoids to recapitulate the morphological and functional characteristics of diffuse-type gastric cancer for FDA-approved drug screening.

Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists

[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.

Tumor Transcriptome-Wide Expression Classifiers Predict Treatment Sensitivity in Advanced Prostate Cancers

[Cell] To identify novel biomarker-treatment pairings, researchers examined associations between biological pathways and 14-year survival outcomes of patients randomized in practice-changing Phase III trials. They included transcriptome-wide expression signatures and immunohistochemistry markers on prostate tumors from 1,523 patients.

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Noshin Noorjahan

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