Noshin Noorjahan

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Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI-001 in In Vitro Models of Prostate Cancer Drug Resistance

[ChemMedChem] Scientists reported the synthesis and biological characterization of a novel class of compounds designed through covalently linking enzalutamide and epichlorohydrin scaffolds-001 through various triazole based linkers.

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UHPLC-MS/MS-GNPS Based Phytochemical Investigation of Dryopteris ramosa (Hope) C. Chr. And Evaluation of Cytotoxicity against Liver and Prostate Cancer Cell Lines

[Heliyon] The authors investigated the detailed phytochemical profile of Dryopteris ramosa and its cytotoxic potential using various cancer cell lines.

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The Diagnostic Role and Mechanistic Functions of Exosomal lncRNAs in Prostate Cancer

[Clinical and Translational Oncology] Researchers focus on the summary of diagnostic roles and mechanistic functions about exosomal long non-coding RNAs in prostate cancer.

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The Prostate Cancer Foundation Announces 2022 Young Investigator Awards Totaling $7.2 Million for Prostate Cancer Research

[Prostate Cancer Foundation] The Prostate Cancer Foundation announced the Class of 2022 Young Investigator Award recipients totaling $7.2 million in funding for innovative prostate cancer research.

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Prostate Cancer Centre of Excellence to Open at Queen’s Thanks to £1.6M Donation

[Queen's University Belfast] A new Prostate Cancer Centre of Excellence is set to open at Queen’s University Belfast, thanks to a generous £1.6million gift to establish a clinical research facility at the Patrick G. Johnston Centre for Cancer Research.

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3D Imaging Analysis on an Organoid-Based Platform Guides Personalized Treatment in Pancreatic Ductal Adenocarcinoma

[Journal of Clinical Investigation] Researchers retrospectively quantified apoptotic responses and tumor-stromal cell proportions in patient-derived organoids (PDOs) via 3D immunofluorescence imaging through annexin A5, α-smooth muscle actin, and cytokeratin 19 levels.

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Aberrant PJA2-CHRM3 Signaling Creates a Therapeutic Vulnerability in Gastric Tumor

[British Journal of Cancer] Scientists constructed mouse gastric organoids to recapitulate the morphological and functional characteristics of diffuse-type gastric cancer for FDA-approved drug screening.

Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists

[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.

Tumor Transcriptome-Wide Expression Classifiers Predict Treatment Sensitivity in Advanced Prostate Cancers

[Cell] To identify novel biomarker-treatment pairings, researchers examined associations between biological pathways and 14-year survival outcomes of patients randomized in practice-changing Phase III trials. They included transcriptome-wide expression signatures and immunohistochemistry markers on prostate tumors from 1,523 patients.

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Noshin Noorjahan

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