Noshin Noorjahan

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Vitamin D Deficiency Aggravates Growth and Metastasis of Prostate Cancer through Promoting EMT in Two β-Catenin-Related Mechanisms

[The Journal of Nutritional Biochemistry] In vitro experiments showed that calcitriol, an active vitamin D3, inhibited migration and invasion in transforming growth factor-β1 -stimulated and -unstimulated PC-3 and DU145 cells.

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Exploiting Ligand Binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors

[Molecular Cancer Therapeutics] Investigators applied the structural information of the ligand binding domain (LBD) dimerization interface of androgen receptor (AR) to screen in silico for AR inhibitors. A completely new binding site, the DIM pocket, was identified at the LBD dimerization interface.

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AZIN1 RNA Editing Alters Protein Interactions, Leading to Nuclear Translocation and Worse Outcomes in Prostate Cancer

[Experimental & Molecular Medicine] After comparison of wild-type Antizyme Inhibitor 1 (AZIN1) and edited AZIN1 (edAZIN1), investigators reported differential binding of edAZIN1 to a small set of proteins.

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LncNAP1L6 Activates MMP Pathway by Stabilizing the m6A-Modified NAP1L2 to Promote Malignant Progression in Prostate Cancer

[Cancer Gene Therapy] Functional assays manifested that silencing of lncNAP1L6 hampered cell migration, invasion, and epithelial-mesenchymal transition (EMT) while overexpression of lncNAP1L6 exacerbated cell migration, invasion, and EMT.

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LncRNA TMEM147-AS1/miR-133b/ZNF587 Axis Regulates Warburg Effect and Promotes Prostatic Carcinoma Invasion and Proliferation

[The Journal of Gene Medicine] LncRNA TMEM147-AS1, miR-133b, and ZNF587 levels in prostatic carcinoma tissues and cells were detected by PCR or Western blot assays.

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Loss of miR-936 Leads to Acquisition of Androgen-Independent Metastatic Phenotype in Prostate Cancer

[Scientific Reports] Researchers found the downregulation of miR-936 in metastatic prostate cancer wherein its target ANXA2, a calcium-dependent phospholipid binding protein, was overexpressed.

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Aberrant PJA2-CHRM3 Signaling Creates a Therapeutic Vulnerability in Gastric Tumor

[British Journal of Cancer] Scientists constructed mouse gastric organoids to recapitulate the morphological and functional characteristics of diffuse-type gastric cancer for FDA-approved drug screening.

Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists

[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.

Tumor Transcriptome-Wide Expression Classifiers Predict Treatment Sensitivity in Advanced Prostate Cancers

[Cell] To identify novel biomarker-treatment pairings, researchers examined associations between biological pathways and 14-year survival outcomes of patients randomized in practice-changing Phase III trials. They included transcriptome-wide expression signatures and immunohistochemistry markers on prostate tumors from 1,523 patients.

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Noshin Noorjahan

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