Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

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Why Is the Brain Versatile? Armenise-Harvard Foundation Award 1 Million Dollars to Study the Adaptive Abilities of the Brain

October 10, 2025

[Istituto Italiano di Tecnologia (EurekAlert)] The human brain is able to adapt to different situations, ensuring flexible and effective behavior. The biological mechanisms underlying this ability are the main research focus of neurobiologist Angelo Forli, who received the prestigious Career Development Grant from the Giovanni Armenise Harvard Foundation.

The PCNA Inhibitor AOH1996 Suppresses Cancer Stemness and Enhances Anti-PD1 Immunotherapy in Squamous Cell Carcinoma

October 7, 2025

[Stem Cell Research & Therapy] The effects of AOH1996 on head and neck squamous cell carcinoma (HNSCC) biological behaviors and cancer stemness were tested in HNSCC cells and nude mice.

HUWE1 Loss Promotes Stemness and Drug Resistance in CRC with Dysregulated β-catenin Destruction Complex

October 7, 2025

[Cell Death Discovery] The authors highlighted HUWE1 as a pivotal regulator of Wnt/β-catenin signaling, particularly in colorectal cancer (CRC) cases characterized by frequent APC mutations. Their findings further show that HUWE1 loss in CRC cells stabilizes β-catenin, enhancing CSC traits and promoting epithelial-mesenchymal transition.

Shen-Bai-Jie-Du Decoction Inhibits Colorectal Tumorigenesis by Attenuating the Malignancy of Cancer Stem Cells via the Gut Microbiota-Bile Acid-FXR Axis

October 7, 2025

[Phytomedicine] Investigators elucidated the mechanism through which Shen-Bai-Jie-Du decoction suppresses colorectal CSC aggressiveness by modulating the gut microbiota-bile acid-Farnesoid X receptor signaling axis.

Dual Targeting of EphAs and KDR Axis Hampers VEGF-Induced Angiogenesis and Glioma Stem Cell Replication

October 7, 2025

[Biochemical Pharmacology] Investigators presented the characterization of UniPR1449, a novel small-molecule selective EphA receptor inhibitor. In patient-derived glioma stem-like cells, the compound significantly reduced proliferation and S-phase entry.

Pharmacological Inhibition of JNK-MAPK Disrupts Cigarette Smoke-Induced RUNX2/Galectin-3 Driven EMT and Cancer Stemness in Lung Adenocarcinoma

October 7, 2025

[Biochemical Pharmacology] Cigarette smoke exposure markedly elevated intracellular reactive oxygen species, assessed via DCFH-DA assay, and promoted invasive behavior, spheroid formation, and colony formation, the hallmarks of cancer stemness.

miRNA-195-5p Modulates Cell Proliferation and Stemness by Targeting the Wnt Signaling Network in Breast Cancer

October 7, 2025

[Non-Coding RNA Research] Scientists investigated the regulatory role of miR-195-5p in modulating CSC properties and associated signalling pathways in breast cancer.

SUV39H2 Is a Vulnerability in Glioblastoma Stem Cells Enhanced by Co-Targeting SUV39H1

October 7, 2025

[Epigenomics] Researchers investigated the role of SUV39H2 in glioblastoma (GBM) stem cells (GSCs) and assessed whether co-targeting SUV39H2 and SUV39H1 more effectively disrupts GSC maintenance, offering a potential strategy to improve GBM treatment.

Frizzled 7 Drives Amplification of Cancer Stem-Cell Subpopulations and the Aggressiveness and Poor Differentiation of Human Hepatocellular Carcinoma

October 7, 2025

[PLOS One] Researchers investigated the role of the FZD7-mediated signaling in immature phenotype and aggressiveness of hepatocellular carcinoma *(HCC). 499 human HCCs were used for clinical and molecular comparisons regarding the expression of FZD7 and stemness-associated markers.

HOXB13 Affects the Cancer Stem Cell Characteristics of Nasopharyngeal Carcinoma by Regulating the Wnt/β-Catenin/SOX2 Pathway

October 7, 2025

[Hereditas] Scientists investigated the function of HOXB13 in nasopharyngeal carcinoma (NPC) and elucidated its underlying mechanism to identify novel targets for NPC diagnosis and therapy.

Exosomal Non-Coding RNAs: Mediators of Crosstalk between Cancer and Cancer Stem Cells

October 7, 2025

[Cell Death Discovery] To comprehensively illuminate the mechanism of exosomal ncRNAs in mediating bidirectional communication between CSCs and differentiated tumor cells within the tuomr microenvironment, the authors systematically analyzed the state-of-the-art literature from PubMed on this topic.

AlphaMedixTM (212pb-DOTAMTATE) Achieved All Primary Efficacy Endpoints in Phase II Study, Demonstrating Clinically Meaningful Benefits in Patients with Gastroenteropancreatic Neuroendocrine Tumors

October 7, 2025

[Sanofi] Positive results from the ALPHAMEDIX-02 Phase II study showed AlphaMedixTM met all primary efficacy endpoints and showed clinically meaningful overall response rates and prolonged clinical benefits in both peptide receptor radionuclide therapy (PRRT)-naïve and PRRT-exposed patients with unresectable or metastatic SSTR-positive gastroenteropancreatic neuroendocrine tumors.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.