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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
MAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell
[Cell Death Discovery] Researchers presented a proof-of-concept PROTAC design tailored for glioblastoma (GBM) stem cells, potentially addressing the occurrence challenges for GBM.
PNO1 Enhances Ovarian Cancer Cell Growth, Invasion, and Stemness via Activating the AKT/Wnt/β-catenin Pathway
[Scientific Reports] The authors demonstrated that PNO1 silencing markedly reduced the proliferation and invasion capabilities of ovarian cancer cell lines, triggering their apoptosis.
Unraveling the Triad of Hypoxia, Cancer Cell Stemness, and Drug Resistance
[Journal of Hematology & Oncology] Investigators elucidate the interplay between hypoxia and CSCs, as well as their correlation with resistance to therapeutic drugs.
PHGDH Activation Fuels Glioblastoma Progression and Radioresistance via Serine Synthesis Pathway
[Journal of Experimental & Clinical Cancer Research] In silico analysis of glioblastoma patient data assessed serine synthesis pathway enrichment and phosphoglycerate dehydrogenase (PHGDH) expression linked with tumor stemness.
A Positive Feedback Loop of OTUD1 and C-Jun Driven by Leptin Expedites Stemness Maintenance in Ovarian Cancer
[Oncogene] The deubiquitinase OTUD1 was identified as a critical regulator of leptin in maintaining ovarian CSCs properties.
New Insights on Anti-Tumor Immunity of CD8+ T Cells: Cancer Stem Cells, Tumor Immune Microenvironment, and Immunotherapy
[Journal of Translational Medicine] Investigators review the research on the regulation of tumor development and prognosis by CSCs that directly or indirectly alter the role of tumor-infiltrating CD8+ T cells.
CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor-Associated Macrophages to Promote Tumor Progression
[Advanced Science] Integrative analyses of single-cell RNA sequencing, cytokine/chemokine arrays, proteomics, and mRNA expression datasets were performed to reveal crosstalk between tumor-associated macrophages and anaplastic thyroid CSCs (ATCSCs) and signaling pathways in ATCSCs.
PD-L1+ CD49f+ CD133+ Circulating Tumor Cells Predict Outcome of Patients with Vulvar or Cervical Cancer after Radio- and Chemoradiotherapy
[Journal of Translational Medicine] In this prospective, longitudinal study, scientists verified the presence of circulating tumor cells (CTCs) via immunofluorescence and systemically characterized CTCs by flow cytometry from the blood of 40 patients with vulvar and 115 patients with cervical cancer.
SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells
[Cancer Research] Scientists validated the critical role of the histone methyltransferase SET and MYND domain containing 3 (SMYD3) in the maintenance of leukemia stem cells in chronic myeloid leukemia.
SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells
[Cancer Research] Scientists validated the critical role of the histone methyltransferase SET and MYND domain containing 3 (SMYD3) in the maintenance of leukemia stem cells in chronic myeloid leukemia.
Coeptis Therapeutics Secures Worldwide Development and Commercialization Rights to Next-Generation GEARâ„¢ Cell Therapy Platform Strengthening its High-Impact Precision Immuno-Oncology Pipeline
[COEPTIS, Inc.] COEPTIS, Inc. announced it has successfully licensed exclusive worldwide development and commercialization rights to the GEARâ„¢ Cell Therapy Platform, representing a first-in-class approach to modifying potent cancer-targeting immune cells to optimize the likelihood of deep remission in patients with hematologic malignancies and other cancers.
Diversity of ER-Positive and HER2-Negative Breast Cancer Stem Cells Attained Using Selective Culture Techniques
[Scientific Reports] Researchers explored breast cancer stem cell diversity and establish a methodology for selectively culturing breast cancer stem cells.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
