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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell-Like Phenotype in Head and Neck Squamous Cell Carcinoma
[Cancer Research] Scientists identified human papillomavirus (HPV) E5 as a viral mediator of resistance to standard-of-care therapies for HPV-associated head and neck squamous cell carcinoma by promoting a stem cell–like phenotype that enhances DNA damage responses and tumor cell survival.
A Novel lncRNA-Mediated Signaling Axis Governs Cancer Stemness and Splicing Reprogramming in Hepatocellular Carcinoma with Therapeutic Potential
[Journal of Experimental & Clinical Cancer Research] Researchers performed integrated bulk and single-cell RNA-Seq analyses combined with functional assays to identify key lncRNAs associated with splicing regulation and cancer stemness in hepatocellular carcinoma.
GPX1 Expression Promotes Stemness and Aggressiveness in Myxoid Liposarcomas
[International Journal of Biological Sciences] Scientists compared the proteomes of adherent and CSC-enriched tumor sphere cultures in a tumor progression model of myxoid liposarcoma composed of three cell lines showing increasing aggressiveness after being serially transplanted in mice.
Wnt/ERK/CDK4/6 Activation in the Partial EMT State Coordinates Mammary Cancer Stemness with Self-Renewal and Inhibition of Differentiation
[British Journal of Cancer] Investigators unravelled a mechanism whereby the hybrid epithelilal-mesenthymal transition state regulates stemness, self-renewal, and differentiation via transient Wnt/ERK/CDK4/6 activation, which can be leveraged for cancer stem cell therapy.
Pir-19521 Facilitates Cancer Stem Cell-Like Properties by Enhancing ALX4 Transcription via an Enhancer RNA-Like Mechanism in Colorectal Cancer
[International Journal of Biological Macromolecules] Researchers identified piR-19521 as up-regulated in colorectal cancer, with higher levels correlating with poorer differentiation, implicating a potential role in colorectal cancer stem cells.
The Role of Chaf1b in Maintaining Glioma Stem Cells Stemness and Regulating Microglial Polarization
[Journal of Neuroscience] Using intracranial xenograft models established in four-week-old male BALB/c nude mice and patient-derived primary glioma stem cells, investigators uncovered a critical function of the chromatin assembly factor subunit Chaf1b in sustaining the stemness of glioblastoma stem cells and modulating the tumor immune microenvironment.
E3 Ubiquitin Ligase WSB1-Mediated Ubiquitination Modification of DIO2 Promotes Colorectal Cancer Stemness and Metastasis by Blocking Thyroid Hormone Signaling
[Biochemical Pharmacology] Researchers examined the mechanism of WD repeat and SOCS box-containing protein 1 (WSB1), an E3 ubiquitin ligase, in colorectal cancer (CRC) liver metastasis. The roles of the WSB1/type II iodothyronine deiodinase/T3/TRβ1 axis in CRC cell proliferation, migration, invasion, and stemness were also probed.
Single-Cell Transcriptomic Insights into ccRCC: A Stemness Gene Signature for Prognosis and Treatment Response Prediction
[Discover Oncology] Through a sophisticated LASSO-XGBoost machine learning approach, researchers constructed a novel stemness-related gene signature that demonstrated exceptional predictive capabilities across multiple independent cohorts.
Deciphering the Crucial Role of IGF2BP3 in Modulating Stemness Traits of Salivary Adenoid Cystic Carcinoma
[Medical Oncology] Leveraging single-cell sequencing data, investigators corroborated the association between insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and stemness traits within salivary adenoid cystic carcinoma cells.
Photodynamic Therapy Boosts the Anti-Proliferative Activity of Oxaliplatin in Cervical Cancer Cells by Regulating Stemness-Related Genes
[Medical Oncology] The combination of zinc phthalocyanine-mediated photodynamic therapy and oxaliplatin exhibited potent anti-cancer effects by inducing apoptosis, suppressing migration, reducing stemness, and modulating key cancer-related pathways.
The Role of Tumor Microenvironment and Signaling Pathways in Regulating Breast Cancer Stem Cells: Implications for Therapy Resistance and Tumor Recurrence
[Drug Resistance Updates] The authors focus on the surface markers of breast cancer stem cells, their roles in recurrence and metastasis, and the key signaling pathways.
Dewpoint Therapeutics Announces an Open IND for First-in-Class Condensate Modulator DPTX3186 for Wnt-Driven Cancers
[Dewpoint Therapeutics] Dewpoint Therapeutics announced the opening of an Investigational New Drug application to the US DFA for DPTX3186, a first-in-class, only-in-class oral condensate modulator designed to selectively disrupt oncogenic Wnt/β-catenin signaling in tumors.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
