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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
A Nanovaccine Targeting Cancer Stem Cells and Bulk Cancer Cells for Postoperative Cancer Immunotherapy.
[Nature Nanotechnology] Researchers proposed a nanovaccine strategy, called NICER, based on a nanovesicle system integrating CSC-specific antigen display and epigenetic nano-regulator encapsulation with a dendritic-cell-targeting aptamer, to simultaneously eradicate CSCs and bulk tumour cells.
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.
[Cancer Research] Investigators suggested that class III phosphoinositide 3-kinase-peripheral lysosomal signaling to mTORC1 may represent a targetable axis for preventing dormant cancer cell–initiated metastasis in patients with breast cancer.
ECT2+ Cell Group Acts As Cancer Stem Cell in Malignant Pleomorphic Adenoma
[NPJ Precision Oncology] Researchers provided new insights into salivary carcinoma ex pleomorphic adenoma (CXPA) diversity and origin, with substantial clinical implications for targeting the ECT2 gene in CXPA treatment.
REPS2 Attenuates Cancer Stemness through Inhibiting Wnt Signaling by Autophagy Mediated Degradation of β-catenin
[Oncogene] Investigators conducted a genome-wide CRISPR/Cas9-mediated screening and identified REPS2 as a potent tumor suppressor genes that negatively regulates the stemness of lung cancer cells.
Targeted Inhibition of Ninjurin2 Promotes Chemosensitivity in Chemoresistant Gastric Cancer by Suppressing Cancer-Initiating Cells.
[Biomarker Research] Scientists suggested that NINJURIN2 could be used as a novel biomarker for chemoresistant gastric cancer patients and that inhibiting NINJURIN2 along with standard chemotherapy could prevent chemoresistance-associated relapse in gastric cancer.
Development of a Circadian-Related Prognostic Signature Highlights RBM17 As a Stemness Regulator in Liver Cancer
[Cancer Cell International] In vivo and in vitro experiments demonstrated that RBM17, identified as a crucial dysregulated LCG, promotes the progression of liver cancer and cisplatin resistance by facilitating cancer stem cell phenotype.
Identification of the Pro-Tumorigenic Role of the ELK4-METTL3-CEMIP Axis in Colorectal Carcinoma: Promotion of Cancer Cell Stemness and Malignant Phenotypes.
[Journal of Gastroenterology and Hepatology] Scientists explored the specific role of CEMIP in the malignant phenotypes and stemness of colorectal cancer cells. CEMIP restoration reversed METTL3 knockdown-driven alterations in cell phenotypes and stemness.
Survivin Knockout Attenuates the Progressiveness of BT549 Triple Negative-Breast Cancer Cells: An In Vitro Study Highlighting Stemness and Cellular Stress Response Mechanisms
[Molecular Biology Reports] The authors evaluated the effects of survivin knockout on triple negative-breast cancer progressiveness relating to proliferation, apoptosis, stemness, cellular stress response, and metastasis mechanisms.
HPV16 E7 Enhances Cell Stemness via RTKN2-Mediated Activation of the NF-κB Pathway in Cervical Cancer.
[Biochemical Genetics] Upregulated rhotekin 2 activated the NF-κB signaling pathway, enhanced the stemness of cervical cancer cells, and ultimately promoted malignant progression.
Prostate Cancer Stem Cell Dynamics in the Evolution of Drug Resistance
[International Journal of Surgery] Investigators synthesized current knowledge on the identity, regulation, and functional dynamics of prostate stem cells, emphasizing their role in shaping the tumor ecosystem.
City of Hope Awarded $23.7 Million to Map Biomarkers Linked to Treatment Resistance in Patients With Common Lung Cancer
[City of Hope] City of Hope® has been awarded an up to $23.7 million contract from the Advanced Research Projects Agency for Health within the US Department of Health and Human Services. The grant will help City of Hope create a bio map of tumor changes that cause immunotherapy resistance in advanced or metastatic non-small cell lung cancer (NSCLC).
SMYD3 Activates Fatty Acid β-Oxidation to Promote Self-Renewal of Leukemia Stem Cells
Researchers validated the critical role of the histone methyltransferase SET and MYND domain-containing 3 (SMYD3) in the maintenance of leukea stem cells in chronic...
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
