Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Oncolytic Herpes Simplex Virus Expressing IL-2 Controls Glioblastoma Growth and Improves Survival

[Journal For Immunotherapy Of Cancer] The authors developed G47Δ-mIL2 using the flip-flop herpes simplex virus BAC system to deliver IL-2 locally within the tumor microenvironment (TME). They then tested its efficacy in orthotopic mouse GBM models and evaluated immune profiles in the treated tumors and spleens by flow cytometry and immunohistochemistry.

Cancer Stem Cell-Immune Cell Crosstalk in the Tumor Microenvironment for Liver Cancer Progression

[Frontiers Of Medicine] Scientists shed light on the bidirectional crosstalk between liver CSCs and immune cells for liver cancer progression, as well as the underlying molecular mechanisms after presenting an overview of liver CSCs characteristic and their microenvironment.

TAK1 Inhibition Leads to RIPK1-Dependent Apoptosis in Immune-Activated Cancers

[Cell Death & Disease] To identify novel therapeutic approaches, researchers performed CRISPR/Cas9 knockout screens and discovered TGFβ activated kinase (TAK1) as a selective survival factor in a significant fraction of glioma stem cells.

MSLN Induced EMT, Cancer Stem Cell Traits and Chemotherapy Resistance of Pancreatic Cancer Cells

[Heliyon] The authors investigated the potential roles of mesothelin (MSLN) in chemoresistance and its relationship with proliferation, epithelial-mesenchymal transition, and cancer stemness of pancreatic cancer cells. Human pancreatic cancer cell lines ASPC-1 and Mia PaCa-2 with high and low expression of MSLN, respectively, were selected.

Tumor Endothelial Cell-Derived Sfrp1 Supports the Maintenance of Cancer Stem Cells via Wnt Signaling

[In Vitro Cellular & Developmental Biology - Animal] Investigators elucidated angiocrine factors related to CSC maintenance, focusing on Secreted frizzled-related protein 1 (Sfrp1). Although Sfrp1 is a Wnt pathway-related factor, its impact on tumor tissues remains unknown.

DNMT1/miR-152-3p/SOS1 Signaling Axis Promotes Self-Renewal and Tumor Growth of Cancer Stem-Like Cells Derived from Non-small Cell Lung Cancer

[Clinical Epigenetics] Researchers elucidated the underlying mechanism involving the DNMT1/miR-152-3p/SOS1 axis in regulating the self-renewal and tumor growth of lung cancer stem-like cells.

A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells

[Molecular Neurobiology] Researchers used a multistep in silico screening strategy to identify repurposed candidate drugs against selected therapeutic molecular targets in glioblastoma with potential to concomitantly target glioblastoma stem cells.

Evaxion Announces Phase II Clinical Trial Update: First Patient Completed Dosing with Personalized Cancer Vaccine EVX-01

[Evaxion Biotech A/S] Evaxion Biotech A/S announced that the first patient in its EVX-01 Phase II trial in metastatic melanoma received the last vaccine dose in combination with KEYTRUDA®. The company initiated its Phase II clinical study to assess the efficacy, safety, and ability to induce a tumor-specific immune response of the EVX-01 cancer vaccine in metastatic melanoma patients.

Dynamic Molecular Network Analysis of iPSC-Purkinje Cells Differentiation Delineates Roles of ISG15 in SCA1 at the Earliest Stage

[Communications Biology] The authors investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial neurodegenerative disease that primarily induces death and dysfunction of cerebellum Purkinje cells.

SBU Senior Nishtha Tripathi to Be Inducted Into Competitive ASBMB Honor Society

[At Bonaventure University] St. Bonaventure University senior Nishtha Tripathi of Austin, Texas, is among 31 undergraduate students nationwide who were accepted into the competitive American Society for Biochemistry and Molecular Biology Honor Society for 2024.

IFI35 Regulates Non-Canonical NF-κB Signaling to Maintain Glioblastoma Stem Cells and Recruit Tumor-Associated Macrophages

[Cell Death & Differentiation] Scientists identified that IFI35, a transcriptional regulatory factor, played both cell-intrinsic and cell-extrinsic roles in maintaining glioma stem cells and the immunosuppressive tumor microenviroment.

Circulating Tumor Cells Shielded with Extracellular Vesicle-Derived CD45 Evade T Cell Attack to Enable Metastasis

[Signal Transduction And Targeted Therapy] The authors unequivocally identified a subpopulation of circulating tumor cells (CTCs) shielded with extracellular vesicle-derived CD45 that resisted T cell attack. A higher percentage of CD45+ CTCs was found to be closely correlated with higher incidence of metastasis and worse prognosis in cancer patients.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.