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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
NOX1 and NPY1R Mark Regional Colon Stem Cell Populations That Serve As Cancer Origins In Vivo
[Nature Cell Biology] Researchers reported the identification of NOX1 and NPY1R as cell-surface markers enriched in LGR5+ stem cells predominantly within the caecum and exclusively within the middle and distal colorectum, respectively.
RIPPLY1 Suppresses Cancer Cell Stemness via Targeting TBX19 in CTNNB1-Mutated Hepatocellular Carcinoma
[Advanced Science] Scientists unveiled the role of ripply transcriptional repressor 1 (RIPPLY1) in the regulation of cancer cell stemness in CTNNB1-mutated hepatocellular carcinomas.
Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma
[Cancer Research] Reserachers investigated the expression and distinctive role of IL-1α in tumor progression. The upregulated IL-1α was neither secreted by nor displayed on the cell surface of monocytes; instead, IL-1α translocated into the nucleus to induce the production of IL-8, which effectively enhanced cancer cell stemness and tumor metastasis.
Synapsin III Promotes Neuronal-Like Transdifferentiation of Glioblastoma Stem Cells by Disrupting JAG1-Notch1 Interaction
[Neuro-Oncology] The authors reveal the therapeutic potential of SYN3 in regulating glioblastoma (GBM) stem cell fate and offer a novel differentiation-based approach for GBM therapy.
Integrated Control of Cancer Stemness by σ Receptor in Advanced Prostate Cancer
[Oncogene] Investigators provided evidence of an essential link between the σ1 receptor (σ1R), a ligand-regulated chaperone protein residing preferentially at the endoplasmic reticulum-mitochondria contact sites, and CSCs in castration-resistant prostate cancers.
SOCS1 Depletion Drives Osteosarcoma Stemness and Chemoresistance by Suppressing ACTN4 Degradation
[Acta Pharmacologica Sinica] Scientists investigated the molecular mechanisms underlying the chemoresistance and stemness in osteosarcoma. Two cisplatin-resistant osteosarcoma cell line models were established by culturing parental U2OS and 143B cells with escalating cisplatin concentrations over a 6-month period.
Photodynamic Therapy Using Talaporfin Sodium and Semiconductor Laser Induces Dose and Time Dependent Cytocidal Effect for Human Glioma Derived Stem Cells
[Photodiagnosis and Photodynamic Therapy] Researchers investigated photodynamic therapy using talaporfin sodium in patient-derived glioma stem cells and provided a foundation for future translational research.
Inhibition of PI3K and Hedgehog Signaling Pathway Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation in Ovarian Cancer Stem Cells
[Balkan Medical Journal] Investigators explored the roles of the PI3K/AKT and Hedgehog signaling pathways in vasculogenic mimicry formation and the underlying mechanisms in ovarian cancer stem cells.
Pien Tze Huang Attenuates Cell Proliferation and Stemness Promoted by Mir-483-5p in Hepatocellular Carcinoma Cells
[Chinese Journal of Integrative Medicine] Scientists investigated the effect of miR-483-5p on hepatocellular carcinoma cells proliferation and stemness, as well as the attenuating effect of Pien Tze Huang.
Cancer Stem Cells in Focus: Deciphering the Dynamic Functional Landscape of Stemness in Cancer
[Hepatology] The authors examine CSC heterogeneity and regulation, while highlighting limitations of current markers and models. They propose that not all committed cancer cells sustain tumour growth; rather, a subset with stem-competent potential may dedifferentiate into CSCs.
Xilio Therapeutics Announces Initiation of Phase 2 Trial for Efarindodekin Alfa (XTX301), a Tumor-Activated IL-12, and Achievement of $17.5 Million Development Milestone Under Exclusive...
[Xilio Therapeutics, Inc.] Xilio Therapeutics, Inc. announced the initiation of patient dosing in Phase II of an ongoing Phase I/II clinical trial evaluating efarindodekin alfa, a tumor-activated IL-12, as a monotherapy in patients with certain advanced solid tumors.
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Pro-Tumorigenic T Cell Polarization
[Cancer Discovery] The authors showed that aryl hydrocarbon receptor ligands found in cigarette smoke, like the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, promote pancreatic dysplasia and PDAC progression in a mouse model of this disease.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
