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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Cellular Origins and Lineage Plasticity in Cancer
[Cold Spring Harbor Perspectives In Medicine] The identity of cancer “cells-of-origin” has historically been a source of controversy across tumor types, as it has not been possible to witness the dynamic events giving rise to human tumors.
Stem-Cell States Converge in Multistage Cutaneous Squamous Cell Carcinoma Development
[Science] Investigators generated gene networks for a wide range of stem cell markers from hundreds of samples taken from normal skin, benign tumors, and malignant tumors, and visualized expression of these network metagenes in single cells derived from multiple stages of carcinogenesis.
Tumor Microenvironment-Induced FOXM1 Regulates Ovarian Cancer Stemness
[Cell Death & Disease] Researchers discovered that the pro-tumorigenic transcription factor FOXM1 is specifically induced by the microenvironment in ovarian cancer stem cells, through activation of FAK/YAP signaling.
The Transcriptional Landscape of Cancer Stem-Like Cell Functionality in Breast Cancer
[Journal of Translational Medicine] Investigators associated in vitro mammosphere formation assays with bulk tumor microarray profiling and deconvolution algorithms to map CSC functionality and the microenvironmental landscape in a large cohort of 125 breast tumors.
CD57 Defines a Novel Cancer Stem Cell That Drive Invasion of Diffuse Pediatric-Type High Grade Gliomas
[British Journal of Cancer] Ten highly invasive patient-derived orthotopic xenograft models of pHGG were subjected to isolation of matching pairs of invasive and tumor core cells.
Pembrolizumab for Advanced Urothelial Carcinoma: Exploratory ctDNA Biomarker Analyses of the KEYNOTE-361 Phase 3 Trial
[Nature Medicine] To identify potential biomarkers of response, investigators retrospectively evaluated association of pre- and post-treatment circulating tumor DNA with clinical outcomes in a subset of patients who received pembrolizumab or chemotherapy in KEYNOTE-361.
2-Aryl-1H-imidazo[4,5-f][1,10]phenanthroline-Based Binuclear Ru(II)/Ir(III)/Re(I) Complexes As Mitochondria Targeting Cancer Stem Cell Therapeutic Agents
[Medicinal Chemistry] The cytotoxic screening of the synthesized complexes has revealed that complex Ru2L1 and Ir2L2 are two proficient complexes among all, but Ru2L1 is the most potent complex.
Providence and Ontario Institute for Cancer Research (OICR) Partnering to Discover and Develop mRNA Therapeutics
[Providence Therapeutics, Inc.] Providence Therapeutic Holdings, Inc. and the Ontario Institute for Cancer Research announced the signing of a collaboration agreement for mRNA drug discovery and development.
Dark Force Rising: Reawakening and Targeting of Fetal-Like Stem Cells in Colorectal Cancer
[Cell Reports] The authors discuss critical mechanisms facilitating the plasticity between stem cell states and highlight the heterogeneity observed upon the appearance of fetal-like states. They focus on therapeutic opportunities that arise by targeting fetal-like colorectal cancer cells and how those concepts can be translated into the clinic.
Knockdown of YTHDF2 Initiates ERS-Induced Apoptosis and Cancer Stemness Suppression by Sustaining GLI2 Stability in Cervical Cancer
[Translational Oncology] Researchers showed how YTH N6-methyladenosine RNA-binding protein F2 (YTHDF2) controlled the fate of cervical cancer cells and whether YTHDF2 could be a valid target for the therapy of cervical cancer.
PA28γ Coordinates the Cross-Talk Between Cancer-Associated Fibroblasts and Tumor Cells to Promote OSCC Progression via HDAC1/E2F3/IGF2 Signaling
[Cancer Letters] Using oral squamous cell carcinoma as a model, the authors demonstrated that PA28γ exhibited high expression in cancer-associated fibroblasts, and its expression significantly correlated with the severity of clinical indicators of malignancy.
Vasorin Promotes Endothelial Differentiation of Glioma Stem Cells via Stimulating the Transcription of VEGFR2
[FASEB Journal] Researchers showed that vasorin (VASN) expression positively correlates with glioma-derived endothelial cell signatures in glioma patients. VASN promotes the endothelial differentiation capacity of glioma stem cell (GSC) in vitro and participates in the formation of GSC-derived vessels in vivo.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
