Regenerative Effects of Human Chondrocyte Sheets in a Xenogeneic Transplantation Model Using Immune‐Deficient Rats

Researchers investigated the regenerative effects of human chondrocyte sheets on articular cartilage in a xenogeneic transplantation model using immune‐deficient rats.
[Journal of Tissue Engineering and Regenerative Medicine]
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Self-Assembled Cell Sheets Composed of Mesenchymal Stem Cells and Gelatin Nanofibers for the Treatment of Full-Thickness Wounds

Dorsal wounds transplanted with the cell sheets exhibited higher wound-healing rates when a high concentration of gelatin was immobilized on the surfaces of the nanofibrils.
[Biomaterials Science]
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Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B

The authors developed an adeno-associated virus 3 (AAV3) vector incorporating a compact yet powerful liver-directed promoter as well as optimized human coagulation factor IX cDNA sequence inserted between two AAV3 inverted terminal repeats.
[Human Gene Therapy]
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Metabolic Engineering Generates a Transgene-Free Safety Switch for Cell Therapy

Using genome editing methods, scientists disrupted uridine monophosphate synthetase (UMPS) in the pyrimidine de novo synthesis pathway in cell lines, pluripotent cells and primary human T cells.
[Nature Biotechnology]
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Transamniotic Mesenchymal Stem Cell Therapy for Neural Tube Defects Preserves Neural Function through Lesion-Specific Engraftment and Regeneration

Researchers report that transamniotic bone marrow-derived mesenchymal stem cell therapy for neural tube defects during early development may achieve beneficial functional recovery.
[Cell Death & Disease]
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Fate Therapeutics Announces FDA Clearance of IND Application for First-Ever iPSC-derived CAR T-Cell Therapy

Fate Therapeutics, Inc. announced that the FDA has cleared the company’s Investigational New Drug application for FT819, an off-the-shelf allogeneic chimeric antigen receptor T-cell therapy targeting CD19+ malignancies.
[Fate Therapeutics, Inc.]
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Engineered Off-The-Shelf Therapeutic T Cells Resist Host Immune Rejection

Cells co-expressing chimeric antigen receptors and alloimmune defense receptor persisted in mice and produced sustained tumor eradication in two mouse models of allogeneic T-cell therapy of hematopoietic and solid cancers.
[Nature Biotechnology]
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Suprachoroidal Gene Transfer with Nonviral Nanoparticles

Suprachoroidal injection of nanoparticles containing a VEGF-binding protein expression plasmid significantly suppressed VEGF-induced vascular leakage and neovascularization demonstrating therapeutic potential.
[Science Advances]
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Current Progress in Stem Cell Therapy for Type 1 Diabetes Mellitus

Researchers discuss the current research advances in strategies to obtain insulin-producing cells from different precursor cells and in stem cell-based therapies for diabetes.
[Stem Cell Research & Therapy]
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‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT]
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Transplantation of Human Urine-Derived Neural Progenitor Cells after Spinal Cord Injury in Rats

Using a rat contusive spinal cord injury model, scientists evaluated the survival, migration and differentiation of urine derived induced pluripotent stem cell-neural progenitor cells after transplantation at subacute phase.
[Neuroscience Letters]
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