USP8-Governed GPX4 Homeostasis Orchestrates Ferroptosis and Cancer Immunotherapy

Investigators reported that homozygous deletion of ubiquitin-specific protease 8 (Usp8) in intestinal epithelial cells (IEC) led to architectural changes in the colonic epithelium and shortens mouse lifespan accompanied by increased IEC death and signs of lipid peroxidation.