The authors compare genetics, microbiome, T‐cell infiltrate and resulting epithelial response in psoriasis and atopic dermatitis.
[Journal of Internal Medicine]
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Schäbitz, A., Eyerich, K., & Garzorz‐Stark, N. (n.d.). So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13235 Cite
The ubiquitin proteasome system is a key regulatory factor in the proliferation, differentiation, and collagen secretion of skin fibroblasts.
[Molecular Diagnosis & Therapy]
Researchers demonstrated that altered dendritic cell representation in the skin-draining lymph nodes during sensitization to allergens caused Th2-driven contact hypersensitivity.
[Proceedings of the National Academy of Sciences of the United States of America]
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Miller, H. L., Andhey, P. S., Swiecki, M. K., Rosa, B. A., Zaitsev, K., Villani, A.-C., Mitreva, M., Artyomov, M. N., Gilfillan, S., Cella, M., & Colonna, M. (2021). Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2021364118 Cite
Researchers showed that the increase in glucose uptake and mitochondrial oxidative phosphorylation confers metastatic ability as a result of aryl hydrocarbon receptor nuclear translocator (ARNT) deficiency.
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Dermal fibroblasts (DF) are critical for effective wound healing, so the authors sought to establish whether there were any differences in DF cultured from Type 2 diabetes mellitus donors or those without diabetes.
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Al-Rikabi, A. H. A., Tobin, D. J., Riches-Suman, K., & Thornton, M. J. (2021). Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Scientific Reports, 11(1), 1474. https://doi.org/10.1038/s41598-020-80072-z Cite
Investigators sequenced genomes of single cell-derived clonal lineages obtained from primary skin cells of a large cohort of healthy individuals across a wide range of ages.
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Saini, N., Giacobone, C. K., Klimczak, L. J., Papas, B. N., Burkholder, A. B., Li, J.-L., Fargo, D. C., Bai, R., Gerrish, K., Innes, C. L., Schurman, S. H., & Gordenin, D. A. (2021). UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin. PLOS Genetics, 17(1), e1009302. https://doi.org/10.1371/journal.pgen.1009302 Cite
Researchers obtained third trimester amniotic fluid from term cesarean delivery and isolated and expanded MSCs in vitro. They then generated 10 mm wounds in Leprdb/db diabetic mouse skin, and splinted them open to allow for humanized wound modeling.
[Journal of Translational Medicine]
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The authors investigated the efficacy of Omega-7 isolated from the sea buckthorn oil in ovine burn wound healing models. In vitro, proliferation and migration assays using cultured primary ovine keratinocytes were performed with or without 0.025% and 0.08% Omega-7, respectively.
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Niimi, Y., Pérez-Bello, D., Ihara, K., Fukuda, S., Jacob, S., Andersen, C. R., Baljinnyam, T., Kim, J., Alharbi, S., Prough, D. S., & Enkhbaatar, P. (2021). Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds. Scientific Reports, 11(1), 975. https://doi.org/10.1038/s41598-020-79597-0 Cite
Researchers used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. They detected circulating tumor DNA in 21/23 of histiocytic sarcoma, 2/8of oral melanoma, and 12/13 of lymphoma cases.
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Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y Cite
UNION therapeutics A/S announced that the FDA has approved an Investigational New Drug program (IND) for oral orismilast; a next generation PDE4-inhibitor for the treatment of plaque psoriasis in adults.
[UNION therapeutics A/S]
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InMed Pharmaceuticals Inc. announced top-line results from its 755-102-HV Phase I clinical trial. Results of the study indicate that INM-755 cream was safe and well-tolerated on induced open epidermal wounds, caused no systemic or serious adverse effects, and there were no subject withdrawals due to adverse events.
[InMed Pharmaceuticals Inc.]
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