Cells from 15 fresh tissue samples of suspected non-melanoma skin cancer were seeded on physiological-stiffnesssynthetic gels, and within one hour invasive cell subsets were observed to push/indent the gel surface; clinicopathological results were separately obtained using standard protocols.
[Biomechanics and Modeling in Mechanobiology]
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Kortam, S., Merkher, Y., Kramer, A., Metanes, I., Ad-El, D., Krausz, J., Har-Shai, Y., & Weihs, D. (2021). Rapid, quantitative prediction of tumor invasiveness in non-melanoma skin cancers using mechanobiology-based assay. Biomechanics and Modeling in Mechanobiology. https://doi.org/10.1007/s10237-021-01475-z Cite
The potential of 3D bioprinting for skin applications was presented, highlighting the development of patch-like skin constructs for wound and burn treatment, and skin equivalents for in vitro research and drug development.
[International Journal of Pharmaceutics]
Sorrento Therapeutics, Inc. announced a research collaboration agreement with Mayo Clinic to conduct human clinical proof of concept studies using the Sofusa Lymphatic Drug Delivery System technology across multiple products and indications.
[Sorrento Therapeutics, Inc.]
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Kerecis,Inc. announced the release of Kerecis® Omega3 MicroGraft. The easy-to-use product is intact fish skin divided into fragments, which mold into wound beds.
[Kerecis, Inc. (Business Wire, Inc.)]
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Apyx Medical Corporation announced it has submitted a 510(k) premarket notification to the US FDA, which is intended to obtain a specific clinical indication for the use of Renuvion in dermal resurfacing procedures.
[Apyx Medical Corporation (Business Wire, Inc.)]
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Scientists demonstrated that Lgr6 marked a regionally restricted population of epidermal stem cells that interacted with nerves and specialized in wound re-epithelialization.
[Cell Stem Cell]
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Huang, S., Kuri, P., Aubert, Y., Brewster, M., Li, N., Farrelly, O., Rice, G., Bae, H., Prouty, S., Dentchev, T., Luo, W., Capell, B. C., & Rompolas, P. (2021). Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.05.007 Cite
In vitro biophysical and cellular analyses demonstrated that this compound bound to Von Hippel-Lindau (VHL) and inhibited the VHL–hypoxia-inducible factor-1α (HIF)-1α interaction.
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Li, G., Ko, C.-N., Li, D., Yang, C., Wang, W., Yang, G.-J., Di Primo, C., Wong, V. K. W., Xiang, Y., Lin, L., Ma, D.-L., & Leung, C.-H. (2021). A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nature Communications, 12(1), 3363. https://doi.org/10.1038/s41467-021-23448-7 Cite
The exaggerated images unveiled pseudopodial extensions and increased light scattering as hallmark properties of metastatic cells. Scientists validated this interpretation using live cells spontaneously transitioning between states indicative of low and high metastatic efficiency.
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Zaritsky, A., Jamieson, A. R., Welf, E. S., Nevarez, A., Cillay, J., Eskiocak, U., Cantarel, B. L., & Danuser, G. (2021). Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma. Cell Systems, 0(0). https://doi.org/10.1016/j.cels.2021.05.003 Cite
Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.
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Kim, H. J., Shim, J. H., Park, J.-H., Shin, H. T., Shim, J. S., Jang, K.-T., Park, W.-Y., Lee, K.-H., Kwon, E. J., Jang, H.-S., Yang, H., Lee, J. H., Yang, J.-M., & Lee, D. (2021). Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-02223-w Cite
Investigators examined whether mineralocorticoid receptor antagonists can ameliorate glucocorticoid receptor-mediated skin barrier dysfunction in normal human epidermal keratinocytes, reconstructed human epidermis, and subjects under psychological stress.
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Lee, H., Choi, E.-J., Kim, E. J., Son, E. D., Kim, H.-J., Park, W.-S., Kang, Y.-G., Shin, K.-O., Park, K., Kim, J.-C., Kim, S.-N., & Choi, E. H. (2021). A novel mineralocorticoid receptor antagonist, 7,3’,4’-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids. Scientific Reports, 11(1), 11920. https://doi.org/10.1038/s41598-021-91450-6 Cite
Scientists found that high group 2 innate lymphoid cells (ILC2) infiltration in human melanoma was associated with a good clinical prognosis. ILC2s were critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinated the recruitment and activation of eosinophils to enhance antitumor responses.
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Jacquelot, N., Seillet, C., Wang, M., Pizzolla, A., Liao, Y., Hediyeh-zadeh, S., Grisaru-Tal, S., Louis, C., Huang, Q., Schreuder, J., Souza-Fonseca-Guimaraes, F., de Graaf, C. A., Thia, K., Macdonald, S., Camilleri, M., Luong, K., Zhang, S., Chopin, M., Molden-Hauer, T., … Belz, G. T. (2021). Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nature Immunology, 1–14. https://doi.org/10.1038/s41590-021-00943-z Cite