Metastatic and Non-Metastatic Melanoma Imaging Using Sgc8-C Aptamer PTK7-Recognizer

Sgc8-c was evaluated in a metastatic melanoma model as molecular imaging probe for in vivo diagnostic, and two probes were in vitro evaluated verifying the high specific PTK7 recognition and its internalization in tumor cells by the endosomal route.
[Scientific Reports]
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Adaptations in Hippo-Yap Signaling and Myofibroblast Fate Underlie Scar-Free Ear Appendage Wound Healing in Spiny Mice

Investigators found that following traumatic injury to ear pinnae, myofibroblasts appeared rapidly in both Acomys and mouse yet persisted only in mouse.
[Developmental Cell]
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Effects of Electrical Stimulation on Human Skin Keratinocyte Growth and the Secretion of Cytokines and Growth Factors

The authors demonstrated that the proliferation of keratinocytes and their secretion of cytokines and growth factors could be activated through appropriate electrical stimulation to benefit skin wound healing.
[Biomedical Materials]
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Escape of Hair Follicle Stem Cells Causes Stem Cell Exhaustion during Aging

Investigators used single-cell RNA-seq and assay for transposase-accessible chromatin which revealed reduced expression of cell adhesion and extracellular matrix genes in aged hair follicle-stem cells.
[Nature Aging]
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Epidermal Galactose Spurs Chytrid Virulence and Predicts Amphibian Colonization

Scientists identified skin factors that mediated key events during the early interaction with Batrachochytrium dendrobatidis zoospores, and discovered a marker for host colonization.
[Nature Communications]
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Calcium Silicate Accelerates Cutaneous Wound Healing with Enhanced Re-Epithelialization through EGF/EGFR/ERK-Mediated Promotion of Epidermal Stem Cell Function

The authors observed the effect of calcium silicate (CS) on human epidermal stem cells and investigated its possible mechanism. They explored the therapeutic effect of CS on wound healing and re-epithelialization.
[Burns & Trauma]
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European Medicines Agency Validates Bristol Myers Squibb’s Application for LAG-3-Blocking Antibody Relatlimab and Nivolumab Fixed-Dose Combination as First-Line Treatment for Patients with Unresectable or Metastatic Melanoma

Bristol Myers Squibb announced Marketing Authorization Application (MAA) validation for the LAG-3-blocking antibody relatlimab and nivolumab fixed-dose combination for first-line treatment of adult and pediatric patients with advanced (unresectable or metastatic) melanoma.
[Bristol Myers Squibb]
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Joint Lab to Understand Role of Microbes for Skin Health

Nanyang Technological University and L’Oréal Singapore launched a joint laboratory to conduct research on the microbiome of our skin and scalp.
[Nanyang Technological University]
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Identification of HMGCR as the Anticancer Target of Physapubenolide against Melanoma Cells by In Silico Target Prediction

Scientists demonstrated that physapubenolide (PB) inhibited cell proliferation and migration in melanoma cells by inducing cell apoptosis. They explored the mechanism underlying the anticancer effects of PB through an in silico target prediction study.
[Acta Pharmaceutica Sinica B]
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Construction of a High Fidelity Epidermis-on-a-Chip for Scalable In Vitro Irritation Evaluation

Investigators grew and differentiated human keratinocytes within a microfluidic chip to construct an integrated epidermis-on-a-chip system, which was specially designed to integrate multi-culture units with integrated bubble removal structure.
[Lab On A Chip]
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Mutant Collagen COL11A1 Enhances Cancerous Invasion

Researchers identified type XI collagen α1 chain (COL11A1) mutations in 66 of 100 cutaneous squamous cell carcinoma concentrated in a triple helical region known to produce trans-dominant collagen.
[Oncogene]
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