Bacteria Induce Skin Regeneration via IL-1β Signaling

The Scientists assessed the function of skin bacteria in wound healing and wound-induced hair follicle neogenesis (WIHN), a rare adult organogenesis model.
[Cell Host & Microbe]
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Pinnacle Dermatology, a Chicago Pacific Founders Portfolio Company, Acquires Ariano Dermatology in Naperville, IL

Pinnacle Dermatology, a Chicago Pacific Founders portfolio company, has acquired Ariano Dermatology, led by Dr. Moira Ariano, in Naperville, IL.
[Pinnacle Dermatology (GlobeNewswire)]
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Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin-Gut Axis Communication

Scientists studied the role of exopolysaccharides produced by lactic acid bacteria identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells.
[Molecules]
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Biofrontera Submits Application for FDA Approval of New BF-RhodoLED® XL Lamp

Biofrontera AG announced the submission for approval of a new, significantly larger red-light source for photodynamic therapy to be used in combination with Ameluz®, the BF-RhodoLED® XL, to the US Food and Drug Administration.
[Biofrontera AG (GlobeNewswire)]
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Streptococcus pyogenes Upregulates Arginine Catabolism to Exert Its Pathogenesis on the Skin Surface

Researchers showed that arginine is a nutrient source that promotes the pathogenicity of S. pyogenes on the skin.
[Cell Reports]
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PPP6C Negatively Regulates Oncogenic ERK Signaling through Dephosphorylation of MEK

The authors identified PPP6C, a phosphatase frequently mutated or downregulated in melanoma, as a major MEK phosphatase in cells exhibiting oncogenic ERK pathway activation.
[Cell Reports]
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Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence

Scientists showed that under chronic stress, increased levels of corticosterone prolonged hair follicle stem cell quiescence and maintained hair follicles in an extended resting phase.
[Nature]
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Amplify Antimicrobial Photo Dynamic Therapy Efficacy with Poly-Beta-Amino Esters (PBAEs)

Researchers report for the first time the possibility of harvesting the cell penetrating properties of poly-beta-amino esters in combination with toluidine blue O to shorten antimicrobial photo dynamic therapy exposure time.
[Scientific Reports]
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CYP27A1-Dependent Anti-Melanoma Activity of Limonoid Natural Products Targets Mitochondrial Metabolism

Scientists suggested a strategy for melanoma-specific targeting by exploiting the expression of MITF target gene CYP27A1 and inhibiting mitochondrial oxidative phosphorylation in BRAF mutant melanomas.
[Cell Chemical Biology]
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Transcriptome Analysis of Human Dermal Fibroblasts Following Red Light Phototherapy

Scientists report that red light may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near-infrared light and undergo photophysical reactions.
[Scientific Reports]
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Human Skin Aging is Associated with Increased Expression of the Histone Variant H2A.J in the Epidermis

The Scientists investigated histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging.
[npj Aging and Mechanisms of Disease]
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