Mycobacterial Skin Infection

Scientists review the most recent evidences concerning mycobacterial skin infections, limiting the period of literature research to 2020–2021.
[Current Opinion in infectious Diseases]
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ASLAN Pharmaceuticals Initiates Phase IIb Study of ASLAN004 (Eblasakimab) in Moderate-to-Severe Atopic Dermatitis

ASLAN Pharmaceuticals announced that it has screened the first patient in its Phase IIb dose-ranging clinical study of eblasakimab in adults with moderate-to-severe atopic dermatitis.
[ASLAN Pharmaceuticals]
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Evaxion Biotech Receives Regulatory Clearance to Initiate Phase II Trial of EVX-01 in Combination with KEYTRUDA® for Treatment of Melanoma

Evaxion Biotech A/S announced it received clearance from the Australia Therapeutic Goods Administration to initiate a Phase IIb trial of its patient specific cancer immunotherapy EVX-01 in combination with Merck & Co., Inc.’s anti-PD-1 therapy KEYTRUDA®.
[Evaxion Biotech A/S]
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Deborah Lang, PhD, Receives Grant to Provide New Insights into Stem Cell Function

Deborah Lang, PhD, associate professor of dermatology, has been awarded a three-year, $544,390 grant from the LEO Foundation. The Lang lab and other Boston University School of Medicine collaborators, will investigate gene expression in the stem cells, and how these stem cells change into pigment-producing melanocytes.
[Boston University School of Medicine]
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US FDA Approves Pfizer’s CIBINQO® (abrocitinib) for Adults with Moderate-to-Severe Atopic Dermatitis

Pfizer, Inc. announced that the US FDA approved CIBINQO® (abrocitinib), an oral, once-daily, Janus kinase 1 inhibitor, for the treatment of adults living with refractory, moderate-to-severe atopic dermatitis.
[Pfizer, Inc.]
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Cyclin-Dependent Kinase 4 Expression Alters the Number of Keratinocyte Stem Cells in the Mouse Hair Follicle

The authors reported that stem cells located in the bulge region of the hair follicle expressed high levels of cyclin-dependent kinase 4 through the quiescent phase of the hair cycle.
[Cell Biology International]
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Coordinated Post-Transcriptional Control of Oncogene-Induced Senescence by UNR/CSDE1

Researchers showed that the RNA-binding protein UNR/CSDE1 enabled oncogene-induced senescence in primary mouse keratinocytes.
[Cell Reports]
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Protooncogene MYC Drives Human Melanocyte Melanogenesis and Senescence

Investigators overexpressed MYC in freshly isolated human primary melanocytes and studied the effects on melanocytic proliferation and differentiation.
[Cancer Gene Therapy]
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Viscoelastic Parameterization of Human Skin Cells Characterize Material Behavior at Multiple Timescales

Viscoelastic measurements revealed that 2D adherent metastatic melanoma cells exhibit reduced elasticity compared to their normal counterparts—melanocytes and fibroblasts.
[Communications Biology]
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Focal Adhesion Kinase Plays a Dual Role in TRAIL Resistance and Metastatic Outgrowth of Malignant Melanoma

The authors showed 2nd generation hexameric TRAIL-receptor-agonist IZI1551 to effectively induce apoptosis in malignant melanoma cells irrespective of the intrinsic BRAF/NRAS mutation status.
[Cell Death & Disease]
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Regeneration of Collagen Fibrils at the Papillary Dermis by Reconstructing Basement Membrane at the Dermal–Epidermal Junction

Researchers suggested that reconstructing the basement membrane promoted secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.
[Scientific Reports]
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