Midkine Rewires the Melanoma Microenvironment Toward a Tolerogenic and Immune-Resistant State

Midkine was found to control the transcriptome of melanoma cells, allowing for coordinated activation of nuclear factor-κB and downregulation of interferon-associated pathways.
[Nature Medicine]
Cerezo-Wallis, D., Contreras-Alcalde, M., Troulé, K., Catena, X., Mucientes, C., Calvo, T. G., Cañón, E., Tejedo, C., Pennacchi, P. C., Hogan, S., Kölblinger, P., Tejero, H., Chen, A. X., Ibarz, N., Graña-Castro, O., Martinez, L., Muñoz, J., Ortiz-Romero, P., Rodriguez-Peralto, J. L., … Soengas, M. S. (2020). Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-020-1073-3 Cite
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New Treatment Addressing the Pathogenesis of Psoriasis

Investigators review new insights regarding the pathogenesis of psoriasis, as it relates to dendritic cells, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells.
[International Journal of Molecular Sciences]
Tokuyama, M., & Mabuchi, T. (2020). New Treatment Addressing the Pathogenesis of Psoriasis. International Journal of Molecular Sciences, 21(20), 7488. https://doi.org/10.3390/ijms21207488 Cite
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CHMP Recommends Approval of Dupixent® (Dupilumab) for Children Aged 6 to 11 Years with Severe Atopic Dermatitis

The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion for Dupixent®, recommending to extend the approval in the European Union to include children aged 6 to 11 years with severe atopic dermatitis who are candidates for systemic therapy.
[CHMP (Globe Newswire LLC)]
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AbbVie Submits Regulatory Applications to FDA and EMA for RINVOQ (upadacitinib) in Atopic Dermatitis

AbbVie announced that it submitted applications to the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) seeking approval for RINVOQ for the treatment of adults (15 mg and 30 mg, once daily) and adolescents (15 mg, once daily) with moderate to severe atopic dermatitis.
[AbbVie]
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Dissecting the Roles of GRK2 and GRK3 in μ-Opioid Receptor Internalization and β-arrestin2 Recruitment Using CRISPR/Cas9-Edited HEK293 Cells

Using CRISPR/Cas9-mediated genome editing, scientists established HEK293 cells with knockout of GRK2, GRK3 or both to dissect their individual contributions in β-arrestin2 recruitment and μ-OR internalization upon stimulation with four different agonists.
[Scientific Reports]
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells | Scientific Reports. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41598-020-73674-0 Cite
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Derivatives of Gecko Cathelicidin-Related Antioxidant Peptide Facilitate Skin Wound Healing

Two truncated peptides, Gj-CATH3-(38–42)-peptide and Gj-CATH3-(33–42)-peptide induced HaCaT cell proliferation and prevent decreases in SOD activity and increases of MDA concentration in injured-skin tissue.
[European Journal of Pharmacology]
Derivatives of gecko cathelicidin-related antioxidant peptide facilitate skin wound healing - ScienceDirect. (n.d.). Retrieved October 16, 2020, from https://www.sciencedirect.com/science/article/abs/pii/S001429992030741X?via%3Dihub Cite
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Isolation and Enrichment of Melanocytes from Human Corneal Limbus Using CD117 (C-Kit) as Selection Marker

Investigators report on a facile protocol for the efficient isolation and enrichment of pure populations of human limbal melanocytes by fluorescence-activated cell sorting using antibodies raised against the cell surface marker CD117.
[Scientific Reports]
Polisetti, N., Schlötzer-Schrehardt, U., Reinhard, T., & Schlunck, G. (2020). Isolation and enrichment of melanocytes from human corneal limbus using CD117 (c-Kit) as selection marker. Scientific Reports, 10(1), 17588. https://doi.org/10.1038/s41598-020-74869-1 Cite
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Dermal Fibroblasts Have Different Extracellular Matrix Profiles Induced by TGF-β, PDGF and IL-6 in a Model for Skin Fibrosis

Researchers investigated the expression of extracellular matrix by dermal fibroblast mimicking fibrotic skin diseases as systemic sclerosis using clinically validated biomarkers.
[Scientific Reports]
Juhl, P., Bondesen, S., Hawkins, C. L., Karsdal, M. A., Bay-Jensen, A.-C., Davies, M. J., & Siebuhr, A. S. (2020). Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis. Scientific Reports, 10(1), 17300. https://doi.org/10.1038/s41598-020-74179-6 Cite
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Integrative Transcriptomic Analysis for Linking Acute Stress Responses to Squamous Cell Carcinoma Development

In vitro, Oncostatin M promoted invasiveness of keratinocytes and cutaneous squamous cell carcinoma cells and suppressed apoptosis of irradiated keratinocytes.
[Scientific Reports]
Nguyen, T. N., Rajapakshe, K., Nicholas, C., Tordesillas, L., Ehli, E. A., Davis, C. M., Coarfa, C., Flores, E. R., Dickinson, S. E., Curiel-Lewandrowski, C., & Tsai, K. Y. (2020). Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development. Scientific Reports, 10(1), 17209. https://doi.org/10.1038/s41598-020-74051-7 Cite
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Evelo Biosciences Completes Enrollment in Phase Ib Clinical Trial Cohort Evaluating EDP1815 in Atopic Dermatitis

Evelo Biosciences, Inc. completed enrollment of 24 patients in the Phase Ib clinical trial cohort evaluating EDP1815 in mild to moderate atopic dermatitis. EDP1815 is an investigational oral biologic in development for the treatment of inflammatory diseases
[Evelo Biosciences, Inc.]
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NOTCH1 Gene Amplification Promotes Expansion of Cancer Associated Fibroblast Populations in Human Skin

Researchers report that cancer associated fibroblasts from skin squamous cell carcinomas displayed chromosomal alterations, with heterogeneous NOTCH1 gene amplification and overexpression that also occurred, to a lesser extent, in dermal fibroblasts of apparently unaffected skin.
[Nature Communications]
Katarkar, A., Bottoni, G., Clocchiatti, A., Goruppi, S., Bordignon, P., Lazzaroni, F., Gregnanin, I., Ostano, P., Neel, V., & Dotto, G. P. (2020). NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin. Nature Communications, 11(1), 5126. https://doi.org/10.1038/s41467-020-18919-2 Cite
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