PARP1 Expression Predicts PARP Inhibitor Sensitivity and Correlates with Metastatic Potential and Overall Survival in Melanoma

The authors found that melanoma cells with high basal poly (ADP-ribose) polymerase (PARP1) expression exhibited significantly increased cell death after PARP inhibitor treatment, owing to higher PARP1 trapping compared with melanoma cells with low PARP1 expression.