Elevated IL-22 in Psoriasis Plays an Anti-apoptotic Role in Keratinocytes through Mediating Bcl-xL/Bax

Investigators demonstrated that IL-22 might play an anti-apoptosis role on keratinocytes to balance cell proliferation and apoptosis in psoriatic epidermis.
[Apoptosis]
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Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/p42MAPK Signaling

Scientists showed for the first time that senescent cells were tumor promoters, not tumor initiators, and that they stimulated skin carcinogenesis by elevating p38 MAPK and MAPK/ERK signaling.
[Cancer Research]
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Regulation of ERK Basal and Pulsatile Activity Control Proliferation and Exit from the Stem Cell Compartment in Mammalian Epidermis

This study showed that exit from the stem cell compartment in mammalian epidermis was characterized by pulsatile ERK MAPK activity.
[Proceedings of the National Academy of Sciences of the United States of America]
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Biofabrication of Endothelial Cell, Dermal Fibroblast, and Multilayered Keratinocyte Layers for Skin Tissue Engineering

The authors used biomaterial-based approaches and bioengineered techniques to develop a 3D skin model with layers of endothelial cell networks, dermal fibroblasts, and multilayered keratinocytes.
[Biofabrication]
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Spontaneously Occurring Melanoma in Animals and Their Relevance to Human Melanoma

The authors look at spontaneously occurring animal ‘models’ of melanoma and discuss their relevance to the different types of melanoma found in humans.
[Journal of Pathology]
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Deacetylation by SIRT1 Promotes the Tumor-Suppressive Activity of HINT1 by Enhancing Its Binding Capacity for β-Catenin or MITF in Colon Cancer and Melanoma Cells

This study revealed an acetylation-dependent regulatory mechanism that governed the tumor-suppressive function of HINT1.
[Experimental and Molecular Medicine]
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‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT]
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‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science]
Editorial
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US Bars International Students from Online-Only Learning in Fall

Since higher education institutions ended in-person classes in March due to the COVID-19 pandemic, there has been uncertainty over what classes will look like in the fall. Universities will soon have to come up with an answer.
[The Scientist]
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LOXL2 from Human Amniotic Mesenchymal Stem Cells Accelerates Wound Epithelialization by Promoting Differentiation and Migration of Keratinocytes

Investigators observed increased migration and reduced proliferation and differentiation when keratinocytes were co-cultured in media conditioned by human amniotic epithelial cell and human amniotic mesenchymal stem cells.
[Aging-Us]
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An Optimist Takes the Helm at the National Science Foundation

The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists—who make up a sizeable share of the U.S. research enterprise—to enter the country.
[Science]
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