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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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Generation and Validation of an Aryl Hydrocarbon Receptor Knockout Human Embryonic Stem Cell Line
[Endocrinology] To characterize the aryl hydrocarbon receptor pathway in developing human β-cells, scientists differentiated hESCs into “islet-like” cell clusters in vitro and treated cells with vehicle or dioxin for 24-hours at key stages of differentiation.
ERK Phosphorylates HNRNPF to Promote the Proliferation and Suppress the Differentiation of Embryonic Stem Cells
[Nucleic Acids Research] Scientists demonstrated that extracellular signal-regulated kinase (ERK) 2 phosphorylates heterogenous nuclear ribonucleoprotein F (HNRNPF) on Ser346 and Tyr356. Hnrnpf knockout reduces ESC proliferation rate and promotes ESC differentiation.
Exiting the Ground State: The Broad Spectrum of Cell Fates Accessible from NaïVe Human Pluripotent Stem Cells
[Cellular and Molecular Life Sciences] Investigators discuss the broad spectrum of cell fates accessible from naïve hPSCs and the signaling pathways that guide the exit from the ground state of human pluripotency.
Derivation and Analysis of Human Somatic Sensory Neuron Subtypes Facilitated through Fluorescent hPSC Reporters
[Stem Cell Reports] To improve upon iPSC-based somatosensory disease models, investigators described the generation and validation of a genetic toolset to fluorescently label all or distinct somatosensory subtypes.
CRISPRa-Mediated Disentanglement of the Dux-MERVL Axis in the 2C-Like State, Totipotency, and Cell Death
[Science Advances] Using a CRISPR activation system, investigators unpicked the relative role of Dux and MERVL in zygotic genome activation, totipotent-like characteristics, and cell toxicity.
Modelling Late Gastrulation in Stem Cell-Derived Monkey Embryo Models
[Nature] Using an optimized 3D suspension culture system, researchers have successfully advanced the in vitro culture of a stem cell-derived monkey blastoid to day 25.
Microprotein PLUM Encoded by Lin28b uORF Is a Cytoplasmic Determinant of Pluripotency and Embryonic Development
[Nature Communications] The authors showed that selective translation of an upstream ORF in the 5′ untranslated region of Lin28b produces an 85-amino acid microprotein, pluripotency-associated Lin28b uORF-encoded microprotein.
Dual Role of Oct4 and Sox2 in Controlling the Developmental Capacity and Timing of Tissue Morphogenesis in the Embryonic Lineage
[Developmental Cell] Researchers investigated factors controlling the epithelialization in epiblast cells and implemented sequential loss-of-function approaches in mouse embryos to define the timing of developmental significance.
Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci
[Cell Proliferation] Scientists utilized androgenetic, parthenogenetic and biparental hESCs and their neural derivatives to identify novel imprinted genes by analyzing their methylome and transcriptome profiles.
A Simple and Standardized Method Supports Efficient Derivation of Clinical-Grade Human Embryonic Stem Cells under feeder- and Xeno-Free Conditions
[Stem Cell Research & Therapy] By optimizing culture conditions and inner cell mass isolation method, researchers developed a method that significantly improves the derivation efficiency of hESC lines from clinically surplus and discarded frozen-thawed embryos under feeder- and xeno-free conditions.
Adjusting PSC Culture for Neural Organoid Generation
[Stem Cell Reports] Scientists investigated the proteome and phosphoproteome of hPSCs to uncover the mechanisms that drive neural organoid competence.
Imprinted Binary Colloidal Crystals Support Growth and Stemness of Mouse Embryonic Stem Cells
[ACS Biomaterials Science & Engineering] A parylene-C coating was deposited onto binary colloidal crystals to generate imprinted substrates with concave bowl-like micro/nanotopographies possessing multidirectional symmetry.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
