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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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Mitochondrial Metabolic Imbalance Drives Diploidization in Mouse Haploid Embryonic Stem Cells via NADPH Overload
[Nature Communications] Investigators used metabolic profiling to discover that diploidization is triggered by an imbalance that arises from a smaller cytoplasmic volume and increased mitochondrial density.
Wnt Activation and Dual SMAD Inhibition for Induction and Maintenance of Hindbrain-Like Neural Stem Cell from hiPSCs
[Cell Reports Methods] Researchers aimed to generate induced neural stem cells from hiPSCs having regional specification restricted to the hindbrain by upregulating hindbrain gene expression and downregulating forebrain and spinal gene expression under minimal growth factor conditions.
Establishment of Human Formative Pluripotent Stem Cell-Like Cells Exhibiting Amniotic Differentiation Potentials
[Cell Proliferation] Scientists established human formative pluripotent stem cell-like cells from naïve hESCs, conventional hESCs, hiPSCs, as well as human blastocysts using the three-dimensional Matrigel culture system.
AMPK-P38 Axis Converts Human Pluripotent Stem Cells to NaïVe State
[iScience] Investigators showed that activation of AMP-activated protein kinase (AMPK) or its downstream p38 alone induces naïve conversion.
Chromatin Dynamics of the Klf4 Locus in Mouse Pluripotent Cells
[Scientific Reports] Researchers used the ANCHOR3 DNA labeling system to track multiple cis-regulatory elements and non-regulatory control regions at different positions in the mouse Klf4 locus.
Augmenting Nrf2 Signaling Pathway Promotes Adipocyte Differentiation from Human Embryonic Stem Cells
[Experimental Cell Research] The authors investigated the contribution of nuclear factor erythroid 2-related factor 2 (Nrf2) to adipocyte differentiation using an in vivo teratoma model, a straightforward assay for evaluating the differentiation potential of hESCs.
Bridging Population and Cell: Modelling Complex Diseases with Human Induced Pluripotent Stem Cells
[European Journal of Human Genetics] Scientists review the challenges and opportunities of using iPSCs to model complex diseases, structured around three key themes: detecting subtle effects, modelling environmental context, and expanding genetic diversity.
Icahn School of Medicine at Mount Sinai Awarded $8.2 Million NIH Grant to Investigate the Origins of Blood-Forming Stem Cells
[Mount Sinai] Researchers at the Icahn School of Medicine at Mount Sinai have been awarded an $8.2 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) to investigate the earliest developmental origins of the hematopoietic system.
Applied StemCell and Cellipont Bioservices Partner to Offer a Seamless Path for iPSC-Derived Cell Therapy Development
[Applied StemCell, Inc. ] Applied StemCell, Inc., announced a strategic collaboration designed to streamline and accelerate the development of iPSC-derived cell therapies.
Pluripotent Stem-Cell-Based Screening Uncovers Sildenafil As a Mitochondrial Disease Therapy
[Cell] To accelerate drug discovery for Leigh syndrome (LS), scientists screen a library of 5,632 repurposable compounds in neural cells from LS-patient-derived iPSCs. They identified phosphodiesterase type 5 inhibitors as leads and prioritized sildenafil for its clinical safety.
Poking Pluripotency: Nanoinjection Into Human iPSCs
[Advanced Materials] Investigators reported a customized nanoinjection strategy enabling efficient transfection of hiPSCs with various types of reporter messenger RNA.
Nonsense-Mediated mRNA Decay Safeguards Telomeres in Pluripotent Stem Cells
[Nature Cell Biology] Researchers showed that a cellular quality control system called nonsense-mediated mRNA decay (NMD), which normally eliminates defective RNA molecules, plays an unexpected role in maintaining telomere integrity in pluripotent cells.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
