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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Mechano-Osmotic Signals Control Chromatin State and Fate Transitions in Pluripotent Stem Cells
[Nature Cell Biology] Researchers focused on preimplantation inner cell mass cells of human embryos and primed pluripotent stem cells, to discover that cell fate transitions associate with rapid, compaction-triggered changes in nuclear shape and volume.
Inducible Differentiation of Buffalo (Bubalus Bubalis) Embryonic Stem Cells Towards Male and Female Germ Cell-Like Lineages under Ex Vivo BMP4-Mediated Stimulation
[Reproductive Biology] Scientists investigated the role of BMP4 in inducing germ lineage development. For this purpose, buffalo ESCs were subjected to in vitro differentiation under suspension as well as adherent cultures, at different BMP4 doses and time periods.
Derivation of Embryonic Stem Cells across Avian Species
[Nature Biotechnology] The authors reported the development of culture conditions for deriving ESCs from chickens and seven other avian species.
A Human-Specific Regulatory Mechanism Revealed in a Pre-Implantation Model
[Nature] Scientists genetically and epigenetically manipulated human blastoids to investigate the functional effect of HERVK long terminal repeat 5Hs on pre-implantation development.
Metal-Organic Polyhedra Maintain the Self-Renewal of Embryonic Stem Cells
[Nature Communications] Researchers developed an innovative strategy using a soluble nanomaterial, metal-organic polyhedra, to effectively maintain the self-renewal and pluripotency of ESC.
In Vitro Modeling of Cell Types in Cardiogenesis and Congenital Heart Disease
[Seminars in Cell & Developmental Biology] The author reviews how research findings have informed the development of new human pluripotent stem cell methods to generate a diverse range of cells in cardiogenesis.
Cell X Technologies and BioLamina Enter a Collaboration to Advance Standardization in iPSC-Based Therapeutics
[Cell X Technologies, Inc (PR Newswire)] Cell X Technologies announced a collaboration with BioLamina to integrate BioLamina's defined laminin reagents with Cell X's Celligent™ platform, aiming to reduce variability and enhance reproducibility in advanced therapy manufacturing.
Dimethyl Sulfoxide Conditions Induced Pluripotent Stem Cells for more Efficient Nephron Progenitor and Kidney Organoid Differentiation
[Stem Cell Reviews and Reports] The authors investigated the impact of treating hiPSCs with a low-dose dimethyl sulfoxide to enhance kidney organoid differentiation using the stepwise 2D monolayer-based protocol developed by Morizane et al. 2017.
Reorganization of H3K9me2-Modified Chromatin Regions during Mouse Embryonic Development
[Developmental Biology] Analysis of H3K9me2-only domains (KODs) from various embryonic mouse tissues revealed that KODs adopt cell type-specific configurations that correlate with changes in lineage-specific enhancer activity.
A Subset of Transposable Elements As Mechano-Response Enhancer Elements in Controlling Human Embryonic Stem Cell Fate
[Nature Cell Biology] Investigators showed that various transposable element families, notably LTR7, undergo transcriptomic, epigenetic and three-dimensional genome changes in response to matrix mechanical cues in hESCs.
Signaling Pathway-Based Culture Condition Improves Differentiation Potential of Canine Induced Pluripotent Stem Cells
[Stem Cell Reports] Investigators have established NANOG-reporter canine iPSC (ciPSC) lines and found that fibroblast growth factor, activin/transforming growth factor-β, and WNT signals were critical for the robust maintenance of ciPSCs.
Signaling Reprogramming via STAT3 Activation Unravels High-Fidelity Human Post-Implantation Embryo Modeling
[Cell Stem Cell] The authors investigated whether STAT3 activation can reprogram PSCs into early fates that self-organize into embryo models.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
