ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Asymmetric Division in a Two-Cell-Like State Rejuvenates Embryonic Stem Cells

February 11, 2026

[Cell Research] Using long-term live-cell imaging to follow the fates of single ESCs, scientists showed that ESC lineage renewal is achieved through sporadic entry into a state characterized by the expression of two-cell embryo-specific markers.

Landscape of microRNA and Target Expression Variation and Covariation in Single Mouse Embryonic Stem Cells

February 11, 2026

[Genome Research] Investigators systematically studied microRNA alternative functions in mouse embryonic stem cells by genetically deleting Drosha, leading to global loss of microRNAs.

Nanog Mediated Control of TBX3-GATA6 Circuitry in Primitive Endoderm Differentiation of mESCs

February 11, 2026

[EMBO Reports] Scientists showed that NANOG partners with TBX3 and the PRC2 complex to maintain ESC identity by silencing primitive endoderm genes through newly identified distal enhancers.

Generation of TCRγδ + T Cells from Human Embryonic Stem Cells

February 11, 2026

[Scientific Reports] By simulating the in vivo developmental process of γδT cells, investigators established stroma cell-free differentiation approach with three stages under 3D suspension culture in conjunction with using hypoxic conditions.

Knockdown of Histone H2A Deubiquitinase BAP1 in Human Embryonic Stem Cells Restricts Their Differentiation Repertoire but Is Dispensable for Maintaining Their Undifferentiated State

February 11, 2026

[Biochemical and Biophysical Research Communications] Scientists generated hESCs that stably express doxycycline inducible BAP1 shRNAs. In the undifferentiated cells, doxycycline addition induced BAP1 downregulation, without any effect on the undifferentiated state.

Establishment of Human Embryonic Stem Cell Line Expressing EGFP Reporter Driven by Human RAX Promoter for Evaluation of Retinal Progenitor Cell Potency

February 11, 2026

[In Vitro Cellular & Developmental Biology - Animal] Researchers provided an efficient approach for monitoring retinal progenitor cells (RPCs) to optimize in vitro maintenance conditions. This was designed by introducing a stable line of hESCs expressing EGFP reporter driven by the human RAX promoter as a key biomarker of RPCs.

Enhancing Human-Induced Pluripotent Stem Cell Proliferation and Cardiac Differentiation through 810-Nm Photobiomodulation

February 11, 2026

[Lasers in Medical Science] Scientists investigated the effects of 810-nm photobiomodulation on the proliferation and cardiac differentiation of hiPSC, utilizing a custom-made LED device.

Harnessing Induced Pluripotent Stem Cells and Organoids for Disease Modeling and Precision Medicine

February 11, 2026

[Stem Cell Research & Therapy] Researchers highlighted how diverse CRISPR modalities—including knock-out, knock-in, CRISPRa/i, and genome-scale screening—have been applied to dissect gene function, model disease progression, and guide therapeutic development using iPSC- and organoid-based systems.

Investigating the Efficacy, Methods, and Challenges of Induced Pluripotent Stem Cells (iPSC) Therapy in Parkinson’s Disease

January 28, 2026

[Neurological Sciences] Investigators highlight the recent progress in the application of stem cell technologies, specifically the utilization of hiPSCs, for the treatment of Parkinson's disease.

Lamin A/C-Regulated Cysteine Catabolic Flux Modulates Stem Cell Fate through Epigenome Reprogramming

January 28, 2026

[Nature Metabolism] Scientists identified lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity.

LDB1 Regulates Gene Expression and Chromatin Structure in Pluripotency and Lineage Differentiation

January 28, 2026

[Nucleic Acids Research] Researchers generated LIM domain-binding 1 (Ldb1)(-/-) ESCs using CRISPR/Cas9 editing and observed a reduction in key stem cell factors SOX2 and KLF4 upon LDB1 loss.

WDR5 Remodels NANOG Condensates to Drive Transcriptional Programs and Sustain Stem Cell Identity

January 28, 2026

[Nature Communications] Investigators identified a direct interaction between NANOG, a master pluripotency transcription factor, and WDR5, a core chromatin regulator essential for maintaining stem cell identity.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.