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ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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Derivation of Embryonic Stem Cells from Cloned Blastocysts Using Improved Somatic Cell Nuclear Transfer in Common Marmosets
[Stem Cell Reports] Scientists established a method for deriving ESCs from blastocysts generated by somatic cell nuclear transfer in the marmoset.
Selectively Inhibition of MAPK Pathway Showed Positive Effects on Porcine Embryo-Derived Stem Cells Pluripotency
[Scientific Reports] To investigate the species-specific molecular mechanism of porcine embryo-derived stem cells (pLCDM) in LCDM condition, scientists compared the biological characteristics of pLCDM and porcine expanded potency stem cells.
Benchmarking and Optimizing Perturb-Seq in Differentiating Human Pluripotent Stem Cells
[Stem Cell Reports] The authors benchmarked Perturb-seq across multiple CRISPRi modalities, on diverse genomic targets, in multiple hPSCs, during directed differentiation to multiple lineages, and across multiple single guide RNA delivery systems.
FIGNL1 Inhibits Homologous Recombination in BRCA2 Deficient Cells by Dissociating RAD51 Filaments
[Science] Researchers demonstrated that loss of the anti-recombinase Fidgetin Like 1 (FIGNL1) retains RAD51 loading at DNA double-stranded breaks in BRCA2-deficient cells, leading to genome stability, HR proficiency, and viability of BRCA2-deficient mESCs.
Engineered Human Induced Pluripotent Stem Cell Models Reveal Altered Podocytogenesis in Congenital Heart Disease-Associated SMAD2 Mutations
[Nature Biomedical Engineering] Scientists investigated the role of pathogenic SMAD2 variants in podocytogenesis, nephrogenic cell lineage specification, and glomerular filtration barrier function.
Transcription Factor ZNF263 Primes Human Embryonic Stem Cells for Pluripotency Dissolution and Lineage Commitment
[Nature Communications] Genetic and functional assays reveal that ZNF263 directly initiates the incipient expression of early differentiation genes and concurrently dampens the core pluripotency circuitry in hESCs.
Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways
[Advanced Science] Researchers reported that Sorcs3 depletion in mESCs enables robust differentiation into both embryonic and extraembryonic lineages, resulting in a totipotent-like state.
In Vivo Differentiation of Embryonic Cells Devoid of Key Reprogramming Factors
[Cell Reports] Scientists investigated the role of Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and differentiation by analyzing the fate of NPS mutant cells in a wild-type embryo using single-cell RNA-seq.
In Vitro Derivation of Midbrain Dopaminergic Neurons from Porcine Embryonic Stem Cells in Multi-Dimensional Conditions
[Stem Cell Research & Therapy] In vitro fertilization- and parthenogenetic activation-derived porcine ESCs were subjected to neural induction using stepwise exposure to dual SMAD inhibition, SHH, CHIR99021, and FGF8.
Dissecting Oct4 Enhancer Function in Pluripotent Stem Cells and Mouse Embryogenesis
[Stem Cell Reports] Researchers generated PSC lines and mouse models with targeted deletions of the Oct4 distal enhancer and proximal enhancer.
A Conserved Function of EZH2-PRC2 in Repression of Primitive Endoderm Fate in Mouse and Human Pluripotent Cells
[Stem Cell Reports] Investigators revealed that enhancer of zeste homolog 2 (EZH2) inhibition with EPZ-6438 transdifferentiates mESCs into primitive endoderm stem cells.
Distinct Roles of Atf3, Zfp711, and Bcl6b in Early Embryonic Hematopoietic and Endothelial Lineage Specification
[Development] Scientists combined multiplexed single-cell RNA sequencing and flow cytometric analysis with knockouts in in vitro differentiating mESCs to dissect the function of these transcription factors in lineage specification.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
