The authors generated two iPSC lines ZNHi001-A and ZNHi001-B from a prostate cancer patient carrying germline mutation in CHEK2 which might increase the risk of prostate cancer. Pluripotency and multi-lineage differentiation capacity of the two iPSC lines were confirmed by gene expression and teratoma assay.
[Stem Cell Research]
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FUJIFILM Cellular Dynamics, Inc. and Sana Biotechnology, Inc. announced that Sana has been granted a non-exclusive right to use FUJIFILM Cellular Dynamics’ iPSC platform for the development of commercial cell therapies.
[FUJIFILM Cellular Dynamics, Inc.]
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The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy]
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Augustine, R., Dan, P., Hasan, A., Khalaf, I. M., Prasad, P., Ghosal, K., Gentile, C., McClements, L., & Maureira, P. (2021). Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy, 138, 111425. https://doi.org/10.1016/j.biopha.2021.111425 Cite
In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.
[npj Parkinsons Disease]
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Researchers compared two previously published protocols to obtain human induced pluripotent stem cell-derived striatal neurons from both healthy donors and Huntington’s disease patients.
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Le Cann, K., Foerster, A., Rösseler, C., Erickson, A., Hautvast, P., Giesselmann, S., Pensold, D., Kurth, I., Rothermel, M., Mattis, V. B., Zimmer-Bensch, G., von Hörsten, S., Denecke, B., Clarner, T., Meents, J., & Lampert, A. (2021). The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells. Scientific Reports, 11(1), 6934. https://doi.org/10.1038/s41598-021-85656-x Cite
Scientists described a high yield approach for isolation and characterization of hESC-derived heart field specific and nodal-like cardiomyocytes.
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Isolation and characterization of hESC-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles | Cardiovascular Research | Oxford Academic. (n.d.). Retrieved March 24, 2021, from https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvab102/6179328?redirectedFrom=fulltext Cite
Scientists provide a simple method for the storage of neural stem cells as neurospheres at ambient temperature as an alternative method to more costly and inconvenient traditional methods of cryopreservation.
[Stem Cell Research & Therapy]
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Li, S., Zhao, H., Han, X., Ni, B., He, L., Mukama, O., de Dieu Habimana, J., Lin, Z., Huang, R., Huang, H., Tian, C., Tang, F., & Li, Z. (2021). Generation of UCiPSC-derived neurospheres for cell therapy and its application. Stem Cell Research & Therapy, 12(1), 188. https://doi.org/10.1186/s13287-021-02238-4 Cite
Researchers determined the therapeutic function of embryonic stem cell derived extracellular vesicles, specifically focusing on their role in immunomodulation after ischemic stroke.
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To selectively label dopaminergic neurons and analyze mitochondrial morphology at the ultrastructural level, investigators generated control and PRKN-mutated patient tyrosine hydroxylase reporter iPSC lines.
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Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN -mutated patient iPSC-derived dopaminergic neurons | Molecular Brain | Full Text. (n.d.). Retrieved March 24, 2021, from https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00771-0# Cite
The authors established a novel and robust monolayer differentiation method to produce functional neural progenitor cells (NPC) from hESC/iPSCs on Type I Collagen. The derived cells not only displayed the requisite markers, but also behaved similarly to classic NPCs both in vitro and in vivo.
[Science China LIfe Sciences]
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Liu, P., Chen, S., Wang, Y., Chen, X., Guo, Y., Liu, C., Wang, H., Zhao, Y., Wu, D., Shan, Y., Zhang, J., Wu, C., Li, D., Zhang, Y., Zhou, T., Chen, Y., Liu, X., Li, C., Wang, L., … Pei, D. (2021). Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen. Science China Life Sciences. https://doi.org/10.1007/s11427-020-1897-0 Cite
To clarify the function of PARP1 in hESCs, scientists report a PARP1 knockout hESC line, generated by CRISPR/Cas9 mediated gene targeting. This cell line showed normal karyotype, pluripotent stem cell marker expression and differentiation potential in vitro.
[Stem Cell Research]