Generation of Two Induced Pluripotent Stem Cell Lines from Blood Cells of a Prostate Cancer Patient Carrying Germline Mutation in CHEK2

The authors generated two iPSC lines ZNHi001-A and ZNHi001-B from a prostate cancer patient carrying germline mutation in CHEK2 which might increase the risk of prostate cancer. Pluripotency and multi-lineage differentiation capacity of the two iPSC lines were confirmed by gene expression and teratoma assay.
[Stem Cell Research]
Liu, R., Qian, K., Xiao, Y., & Jiang, W. (2021). Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2. Stem Cell Research, 53, 102299. https://doi.org/10.1016/j.scr.2021.102299 Cite
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FUJIFILM Cellular Dynamics and Sana Biotechnology Announce License Agreement for the Development of iPSC-Derived Cell Therapies

FUJIFILM Cellular Dynamics, Inc. and Sana Biotechnology, Inc. announced that Sana has been granted a non-exclusive right to use FUJIFILM Cellular Dynamics’ iPSC platform for the development of commercial cell therapies.
[FUJIFILM Cellular Dynamics, Inc.]
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Stem Cell-Based Approaches in Cardiac Tissue Engineering: Controlling the Microenvironment for Autologous Cells

The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy]
Augustine, R., Dan, P., Hasan, A., Khalaf, I. M., Prasad, P., Ghosal, K., Gentile, C., McClements, L., & Maureira, P. (2021). Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy, 138, 111425. https://doi.org/10.1016/j.biopha.2021.111425 Cite
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Astrocytic Atrophy as a Pathological Feature of Parkinson’s Disease with LRRK2 Mutation

In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.
[npj Parkinsons Disease]
Ramos-Gonzalez, P., Mato, S., Chara, J. C., Verkhratsky, A., Matute, C., & Cavaliere, F. (2021). Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation. Npj Parkinson’s Disease, 7(1), 1–11. https://doi.org/10.1038/s41531-021-00175-w Cite
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The Difficulty to Model Huntington’s Disease In Vitro Using Striatal Medium Spiny Neurons Differentiated from Human Induced Pluripotent Stem Cells

Researchers compared two previously published protocols to obtain human induced pluripotent stem cell-derived striatal neurons from both healthy donors and Huntington’s disease patients.
[Scientific Reports]
Le Cann, K., Foerster, A., Rösseler, C., Erickson, A., Hautvast, P., Giesselmann, S., Pensold, D., Kurth, I., Rothermel, M., Mattis, V. B., Zimmer-Bensch, G., von Hörsten, S., Denecke, B., Clarner, T., Meents, J., & Lampert, A. (2021). The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells. Scientific Reports, 11(1), 6934. https://doi.org/10.1038/s41598-021-85656-x Cite
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Isolation and Characterization of hESC-Derived Heart Field-Specific Cardiomyocytes Unravels New Insights into Their Transcriptional and Electrophysiological Profiles

Scientists described a high yield approach for isolation and characterization of hESC-derived heart field specific and nodal-like cardiomyocytes.
[Cardiovascular Research]
Isolation and characterization of hESC-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles | Cardiovascular Research | Oxford Academic. (n.d.). Retrieved March 24, 2021, from https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvab102/6179328?redirectedFrom=fulltext Cite
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Generation of UCiPSC-Derived Neurospheres for Cell Therapy and Its Application

Scientists provide a simple method for the storage of neural stem cells as neurospheres at ambient temperature as an alternative method to more costly and inconvenient traditional methods of cryopreservation.
[Stem Cell Research & Therapy]
Li, S., Zhao, H., Han, X., Ni, B., He, L., Mukama, O., de Dieu Habimana, J., Lin, Z., Huang, R., Huang, H., Tian, C., Tang, F., & Li, Z. (2021). Generation of UCiPSC-derived neurospheres for cell therapy and its application. Stem Cell Research & Therapy, 12(1), 188. https://doi.org/10.1186/s13287-021-02238-4 Cite
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Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke

Researchers determined the therapeutic function of embryonic stem cell derived extracellular vesicles, specifically focusing on their role in immunomodulation after ischemic stroke.
[ACS Nano]
Xia, Y., Hu, G., Chen, Y., Yuan, J., Zhang, J., Wang, S., Li, Q., Wang, Y., & Deng, Z. (2021). Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke. ACS Nano. https://doi.org/10.1021/acsnano.1c00672 Cite
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Establishment of an In Vitro Model for Analyzing Mitochondrial Ultrastructure in PRKN-Mutated Patient iPSC-Derived Dopaminergic Neurons

To selectively label dopaminergic neurons and analyze mitochondrial morphology at the ultrastructural level, investigators generated control and PRKN-mutated patient tyrosine hydroxylase reporter iPSC lines.
[Molecular Brain]
Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN -mutated patient iPSC-derived dopaminergic neurons | Molecular Brain | Full Text. (n.d.). Retrieved March 24, 2021, from https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00771-0# Cite
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Efficient Induction of Neural Progenitor Cells from Human ESC/iPSCs on Type I Collagen

The authors established a novel and robust monolayer differentiation method to produce functional neural progenitor cells (NPC) from hESC/iPSCs on Type I Collagen. The derived cells not only displayed the requisite markers, but also behaved similarly to classic NPCs both in vitro and in vivo.
[Science China LIfe Sciences]
Liu, P., Chen, S., Wang, Y., Chen, X., Guo, Y., Liu, C., Wang, H., Zhao, Y., Wu, D., Shan, Y., Zhang, J., Wu, C., Li, D., Zhang, Y., Zhou, T., Chen, Y., Liu, X., Li, C., Wang, L., … Pei, D. (2021). Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen. Science China Life Sciences. https://doi.org/10.1007/s11427-020-1897-0 Cite
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Generation of PARP1 Gene Knockout Human Embryonic Stem Cell Line Using CRISPR/Cas9

To clarify the function of PARP1 in hESCs, scientists report a PARP1 knockout hESC line, generated by CRISPR/Cas9 mediated gene targeting. This cell line showed normal karyotype, pluripotent stem cell marker expression and differentiation potential in vitro.
[Stem Cell Research]
Li, Y., Li, J., Zhou, T., Pan, G., & Huang, K. (2021). Generation of PARP1 gene knockout human embryonic stem cell line using CRISPR/Cas9. Stem Cell Research, 53, 102288. https://doi.org/10.1016/j.scr.2021.102288 Cite
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