ZFP207 Sustains Pluripotency by Coordinating OCT4 Stability, Alternative Splicing and RNA Export

The authors employed multiple functional analyses to characterize the role of Zinc Finger Protein 207 (ZFP207) in mouse ESCs.
[EMBO Reports]
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Japan University Uses iPS Cells to Treat Spinal Cord Injury for First Time

Keio University in Tokyo said it has started the world’s first clinical test using induced pluripotent stem cells, or iPS cells, to treat patients with spinal cord injuries.
[Kyodo News]
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Establishment of a Developmental Toxicity Assay Based on Human iPSC Reporter to Detect Fibroblast Growth Factor Signal Disruption

Scientists proposed a reporter assay that utilized human iPSCs to detect changes in fibroblast growth factor signaling, which was essential for limb morphogenesis.
[iScience]
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Recapitulating Human Cardio-Pulmonary Co-development Using Simultaneous Multilineage Differentiation of Pluripotent Stem Cells

The authors reported a novel stepwise strategy for directing the simultaneous induction of both mesoderm-derived cardiac and endoderm-derived lung epithelial lineages within a single differentiation of human iPSCs via temporal specific tuning of WNT and nodal signaling in the absence of exogenous growth factors.
[eLife]
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Single-Cell Transcriptomics of Human iPSC Differentiation Dynamics Reveal a Core Molecular Network of Parkinson’s Disease

Researchers investigated Parkinson’s disease (PD)’s mechanism using dopaminergic neurons differentiated from human iPSCs carrying the ILE368ASN mutation within the PINK1 gene, which is strongly associated with PD.
[Communications Biology]
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Integrated Stem Cells from Apical Papilla in a 3D Culture System Improve Human Embryonic Stem Cell Derived Retinal Organoid Formation

The authors assessed the effective interactions of mesenchymal stem cells and human embryonic stem cells during retinal organoid formation.
[Life Sciences]
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Memorial Sloan Kettering Cancer Center Announces the Creation of the Fiona and Stanley Druckenmiller Presidential Innovation Fund

Memorial Sloan Kettering Cancer Center (MSK) announced the launch of the Fiona and Stanley Druckenmiller Presidential Innovation Fund, which is intended to lead to new, more effective ways to treat and cure cancer by rapidly seeding the most promising projects in translational cancer medicine that might otherwise go unfunded.
[Memorial Sloan Kettering Cancer Center]
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Fate Therapeutics Announces FDA Clearance for FT536, a First-in-Class MICA/B-targeted CAR NK Cell Product Candidate for the Treatment of Solid Tumors

Fate Therapeutics, Inc. announced that the US FDA has cleared the company’s Investigational New Drug application for FT536, an off-the-shelf, multiplexed-engineered, iPSC-derived, chimeric antigen receptor NK cell product candidate.
[Fate Therapeutics, Inc.]
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Century Therapeutics and Bristol Myers Squibb Enter into a Strategic Collaboration to Develop iPSC-Derived Allogeneic Cell Therapies

Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement to develop and commercialize up to four iPSC derived, engineered natural killer cell and / or T cell programs for hematologic malignancies and solid tumors.
[Century Therapeutics]
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CRISPR/Cas9-Mediated Gene Knockout and Interallelic Gene Conversion in Human Induced Pluripotent Stem Cells Using Non-Integrative Bacteriophage-Chimeric Retrovirus-Like Particles

Researchers investigated the potential of bacteriophage-chimeric retrovirus-like particles for the non-integrative delivery of RNA molecules in human iPSCs for CRISPR/Cas9 applications.
[BMC Biology]
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Patient-Derived iPSCs Link Elevated Mitochondrial Respiratory Complex I Function to Osteosarcoma in Rothmund-Thomson Syndrome

The authors generated Rothmund-Thomson syndrome (RTS) patient-derived iPSCs to dissect the pathological signaling leading to RTS patient-associated osteosarcoma.
[PLoS Genetics]
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