Harnessing Organs-on-a-Chip to Model Tissue Regeneration

The authors discussed the potential of “organ-on-a-chip” systems to study regenerative therapies with focus on three distinct organ systems: cardiac, respiratory, and hematopoietic.
[Cell Stem Cell]
Tavakol, D. N., Fleischer, S., & Vunjak-Novakovic, G. (2021). Harnessing organs-on-a-chip to model tissue regeneration. Cell Stem Cell, 28(6), 993–1015. https://doi.org/10.1016/j.stem.2021.05.008 Cite
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Human iPS Cells Engender Corneal Epithelial Stem Cells with Holoclone-Forming Capabilities

Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.
[iScience]
Watanabe, S., Hayashi, R., Sasamoto, Y., Tsujikawa, M., Ksander, B. R., Frank, M. H., Quantock, A. J., Frank, N. Y., & Nishida, K. (2021). Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102688 Cite
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Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.
[International Journal of Molecular Sciences]
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Miniaturized 3D Bone Marrow Tissue Model to Assess Response to Thrombopoietin-Receptor Agonists in Patients

Researchers presented a miniaturized bone marrow tissue model that provided a screening bioreactor for personalized, pre-treatment response prediction to Eltrombopag for patients with thrombocytopenic disorders.
[eLife]
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Generation and Characterization of iPSC-Derived Renal Proximal Tubule-Like Cells with Extended Stability

Investigators reported the differentiation and characterization of iPSC lines into proximal tubular-like cells.
[Scientific Reports]
Chandrasekaran, V., Carta, G., da Costa Pereira, D., Gupta, R., Murphy, C., Feifel, E., Kern, G., Lechner, J., Cavallo, A. L., Gupta, S., Caiment, F., Kleinjans, J. C. S., Gstraunthaler, G., Jennings, P., & Wilmes, A. (2021). Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability. Scientific Reports, 11(1), 11575. https://doi.org/10.1038/s41598-021-89550-4 Cite
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Construction of a Mammalian Embryo Model from Stem Cells Organized by a Morphogen Signaling Centre

In situ hybridization, immunolabelling, cell tracking and transcriptomic analyses show that these embryoids form the three germ layers through a gastrulation process and that they exhibit a wide range of developmental structures, highly similar to neurula-stage mouse embryos.
[Nature Communications]
Xu, P.-F., Borges, R. M., Fillatre, J., de Oliveira-Melo, M., Cheng, T., Thisse, B., & Thisse, C. (2021). Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. Nature Communications, 12(1), 3277. https://doi.org/10.1038/s41467-021-23653-4 Cite
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Generation and Genetic Correction of USH2A c.2299delG Mutation in Patient-Derived Induced Pluripotent Stem Cells

To study the molecular mechanisms of Usher syndrome and develop a gene therapy strategy, researchers generated human iPSCs from peripheral blood mononuclear cells obtained from a patient carrying compound heterozygous variants of USH2A c.2299delG and c.1256G>T and the patient’s healthy sibling.
[Genes]
Liu, X., Lillywhite, J., Zhu, W., Huang, Z., Clark, A. M., Gosstola, N., Maguire, C. T., Dykxhoorn, D., Chen, Z.-Y., & Yang, J. (2021). Generation and Genetic Correction of USH2A c.2299delG Mutation in Patient-Derived Induced Pluripotent Stem Cells. Genes, 12(6), 805. https://doi.org/10.3390/genes12060805 Cite
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Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells

Investigators generated a ubiquitin-specific protease 3 gene knockout using the CRISPR/Cas9 system and demonstrated that USP3 acts as a protein stabilizer of Oct4 by deubiquitinating Oct4.
[International Journal of Molecular Sciences]
Rhie, B.-H., Antao, A. M., Karapurkar, J. K., Kim, M.-S., Jo, W.-J., Ramakrishna, S., & Kim, K.-S. (2021). Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells. International Journal of Molecular Sciences, 22(11), 5584. https://doi.org/10.3390/ijms22115584 Cite
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Induced Tissue-Specific Stem Cells (iTSCs): Their Generation and Possible Use in Regenerative Medicine

The authors provide a brief overview of iPSCs and discusses recent advances in the establishment of induced nduced tissue-specific stem cells and their possible applications in regenerative medicine.
[Pharmaceutics]
Pharmaceutics | Free Full-Text | Induced Tissue-Specific Stem Cells (iTSCs): Their Generation and Possible Use in Regenerative Medicine | HTML. (n.d.). Retrieved June 2, 2021, from https://www.mdpi.com/1999-4923/13/6/780/htm Cite
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Human Pluripotent Stem-Cell-Derived Models as a Missing Link in Drug Discovery and Development

By analyzing each stage of the drug discovery and development process, scientists identified the active role of human PSC-derived in vitro models in phenotypic screening, target-based screening, target validation, toxicology evaluation, precision medicine, clinical trial in a dish, and post-clinical studies.
[Pharmaceuticals]
Lin, X., Tang, J., & Lou, Y.-R. (2021). Human Pluripotent Stem-Cell-Derived Models as a Missing Link in Drug Discovery and Development. Pharmaceuticals, 14(6), 525. https://doi.org/10.3390/ph14060525 Cite
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Human Stem Cells Harboring a Suicide Gene Improve the Safety and Standardization of Neural Transplants in Parkinsonian Rats

The engineered FailSafeTM hPSCs demonstrated robust ventral midbrain specification in vitro, capable of forming neural grafts upon transplantation.
[Nature Communications]
de Luzy, I. R., Law, K. C. L., Moriarty, N., Hunt, C. P. J., Durnall, J. C., Thompson, L. H., Nagy, A., & Parish, C. L. (2021). Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats. Nature Communications, 12(1), 3275. https://doi.org/10.1038/s41467-021-23125-9 Cite
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