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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
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Laminin 1 Enhances the Angiogenic and Neurogenic Potential of Collagen-Based Scaffolds for Complex Wound Healing Applications
[Biomaterials Advances] To improve wound healing potential, scientists sought to enhance the collagen-glycosaminoglycan scaffold's pro-angiogenic and pro-neurogenic capacity through addition of fibronectin, collagen IV, or laminin 1 to the scaffold, key extracellular matrix components known to support angiogenic and neurogenic processes.
Mineralized Bone Matrix Attenuates Breast Cancer Cell Malignancy by Altering MSC Mechanoregulation
[Biomaterials] Using biofunctional bone matrix models, investigators found that mineralization prevents mesenchymal stem cell-mediated collagen remodeling by limiting actomyosin contractility while promoting osteogenic differentiation.
RUNX1 N6-Methyladenosine Methylation Enhances Cytoskeleton Remodelling and Boosts Cardiac Fibrosis
[Cardiovascular Research] The authors revealed a novel epitranscriptomic pathway wherein YTHDF1 recognizes m6A-modified Runx1 mRNA, enhancing its translation and thereby stimulating RUNX1-mediated Ctgf transcription.
A Novel GelMA-SPAK Hydrogel with Affinity-Controlled Release of bFGF towards Wound Healing
[Biofabrication] Inspired by the interactions between the extracellular matrix and growth factors in vivo, this study develops a polyanionic hydrogel system for the controlled delivery of basic fibroblast growth factor to regulate healing processes.
14-3-3γ Knockdown Promotes Matrix Mineralization in Human Mesenchymal Stromal Cells
[Cell Death & Disease] Investigators revealed a novel inhibitory role of 14-3-3γ in matrix mineralization of human adipose-derived mesenchymal stem/stromal cells, suggesting that targeting this paralog may offer new avenues for therapies in bone remodeling disorders.
Targeting Fibroblast Activation Protein-α to Treat Renal Fibrosis
[Cellular & Molecular Biology Letters] Targeting fibroblast activation protein as a strategy for treating renal fibrosis was tested using two preclinical animal models: the mouse models of unilateral ureteral obstruction and unilateral renal ischemia–reperfusion.
Progress in Self-Assembled Extracellular Matrix Structural Protein Mimetic Peptides: From Rational Design and Assembly Pathways to Biomedical Applications
[Biomacromolecules] The authors summarize progress in the design and application of ECM-mimetic peptides, focusing on their roles in tissue engineering, regenerative medicine, and drug delivery.
Bone Tissue Engineering Strategies to Treat Critically Sized Defects in Compromised Wound Healing Environments
[ACS Biomaterials Science & Engineering] Scientists provide a detailed overview of in vivo bone regeneration strategies for critically sized defects, specifically within compromised healing environments, summarizing how animal models are developed and how biomaterial, cellular, and drug delivery platforms are tailored to these disease states.
Agomab Receives U.S. Patent for AGMB-447, Its Inhaled Lung-Restricted Small Molecule Inhibitor of ALK5 in Development for the Treatment of Idiopathic Pulmonary Fibrosis
[Agomab Therapeutics NV (Globe Newswire)] Agomab Therapeutics NV announced that the United States Patent and Trademark Office has granted U.S. Patent No. 12,577,230 for AGMB-447, to Agomab. AGMB-447 is the investigational inhaled lung-restricted small molecule inhibitor of ALK5, currently in a Phase Ib study for the treatment of idiopathic pulmonary fibrosis.
Interleukin 11-Induced MicroRNAs As Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis
[Circulation Research] Researchers investigated the translational potential of IL-11–regulated microRNAs as circulating biomarkers of cardiac fibrosis in patients with aortic stenosis.
Tailored Extracellular Matrix-Biomimetic Coating Favors Tissue Healing by Modulating the Microenvironment
[ACS Nano] Scientists proposed an ECM-biomimetic microenvironment-regulating coating, where a polyethylene glycol linker with antifouling effects is used to graft tailored recombinant humanized collagen type I possessing high cell-adhesive activity via an efficient click reaction.
Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis
[Advanced Science] Investigators showed that inhalationally delivered, lung-targeted antisense oligonucleotides against angiopoietin-like 4 attenuate both infectious and fibrotic lung disease.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
