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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
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Early Fibrotic Niches Establish Tumor-Permissive Microenvironments
[Nature] Using integrated single-cell, spatial, and functional analyses, scientists defined the earliest multicellular events that license this transition following oncogenic activation in the lung.
SIRT5 Ameliorates Cardiac Fibrosis via PCK2 Desuccinylation-Mediated Metabolic Reprogramming in Cardiac Fibroblasts
[Circulation] The functional role of SIRT5 in cardiac fibrosis was evaluated through cardiac fibroblast-specific knockout and overexpression of Sirt5 in mice.
VAP1 Promotes Cardiac Fibrosis by Enabling PDGFR Signaling in Myofibroblasts
[Experimental & Molecular Medicine] Researchers investigated the role and targetability of vascular adhesion protein 1 (VAP1) in cardiac fibrosis.
REFRESH-Reversible Embedded Bioprinting for Faster Reinforcement and Structuring of dECM Hydrogels
[Advanced Healthcare Materials] Investigators presented REFRESH—Reversible Embedded Bioprinting for Faster Reinforcement and Structuring of dECM Hydrogels, a next-generation embedded bioprinting platform designed for high-fidelity fabrication of anatomically relevant tissue constructs using dECM hydrogels.
Bioresorbable Fiber Reinforced Hydrogel Scaffold for Cartilage Tissue Regeneration
[Biofabrication] Scientists investigated the printability of medical-grade poly(L-lactide-co-caprolactone) (PLCL), which has a faster degradation rate, resulting in melt electrowriting PLCL scaffolds characterized by uniform fiber diameter, regular layer stacking, and customizable pore sizes.
Targeting Glutamine Metabolism Combined with a Nanoradioenhancer in Radioresistant Hepatocellular Carcinoma
[Nanoscale] Researchers developed a nanoplatform using gold nanodandelions (GNDs@gelatin) as a nanoradioenhancer, loaded with 6-diazo-5-oxo-L-norleucine (DON), to form matrix metalloproteinase-triggered dual-functional RT/metabolic reprogramming nanoplatform, termed GNDs@gelatin/DON.
Heterogeneity and Plasticity of Cancer-Associated Fibroblasts
[Nature Cancer] The authors review the current understanding of cancer-associated fibroblasts as heterogeneous, instructive regulators of tumor microenvironments across anatomic sites and highlight key challenges for the future.
XORTX Announces Closing of Acquisition of Vectus Kidney Anti-fibrotic Asset
[XORTX Therapeutics, Inc.] XORTX Therapeutics, Inc. announced the closing of the acquisition of the Vectus kidney anti-fibrotic asset.
Laminin 1 Enhances the Angiogenic and Neurogenic Potential of Collagen-Based Scaffolds for Complex Wound Healing Applications
[Biomaterials Advances] To improve wound healing potential, scientists sought to enhance the collagen-glycosaminoglycan scaffold's pro-angiogenic and pro-neurogenic capacity through addition of fibronectin, collagen IV, or laminin 1 to the scaffold, key extracellular matrix components known to support angiogenic and neurogenic processes.
Mineralized Bone Matrix Attenuates Breast Cancer Cell Malignancy by Altering MSC Mechanoregulation
[Biomaterials] Using biofunctional bone matrix models, investigators found that mineralization prevents mesenchymal stem cell-mediated collagen remodeling by limiting actomyosin contractility while promoting osteogenic differentiation.
RUNX1 N6-Methyladenosine Methylation Enhances Cytoskeleton Remodelling and Boosts Cardiac Fibrosis
[Cardiovascular Research] The authors revealed a novel epitranscriptomic pathway wherein YTHDF1 recognizes m6A-modified Runx1 mRNA, enhancing its translation and thereby stimulating RUNX1-mediated Ctgf transcription.
A Novel GelMA-SPAK Hydrogel with Affinity-Controlled Release of bFGF towards Wound Healing
[Biofabrication] Inspired by the interactions between the extracellular matrix and growth factors in vivo, this study develops a polyanionic hydrogel system for the controlled delivery of basic fibroblast growth factor to regulate healing processes.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
