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Early-Activated Extracellular Matrix Proteins Shape the Metabolic and Spatial Dynamics of the Kidney Fibrotic Microenvironment

March 11, 2026

[Nature Metabolism] Researchers showed that ECM1 is an early regulator of kidney remodelling. Global Ecm1 knockout mice develop spontaneous fibrosis and early death, whereas ECM1 levels markedly increase in biofluids during chronic kidney disease.

Tailored Extracellular Matrix-Biomimetic Coating Favors Tissue Healing by Modulating the Microenvironment

March 11, 2026

[ACS Nano] Investigators proposed an ECM-biomimetic microenvironment-regulating coating, where a polyethylene glycol linker with antifouling effects is used to graft tailored recombinant humanized collagen type I possessing high cell-adhesive activity via an efficient click reaction.

Ultrasound-Triggered Peroxynitrite-Mediated ECM Degradation to Enhance Sonodynamic Cancer Therapy

March 11, 2026

[Advanced Healthcare Materials] Scientists developed a cascade reaction-enhanced sonodynamic therapeutic system that yields highly cytotoxic peroxynitrite (ONOO⁻). The resulting ONOO⁻ activates matrix metalloproteinases to degrade the ECM, thereby enhancing nanoparticle penetration and establishing a self-reinforcing antitumor cycle.

3D ECM-Inflammation Model on a Microfluidic Chip for Neutrophil Transmigration from Whole Blood Investigations

March 11, 2026

[Lab on a Chip] The authors created a microfluidic chip that recreates an inflammation event and directly isolates neutrophils from a small volume of whole blood using a 3D extracellular matrix.

Arp2/3 Complex and β1 Integrin Drive an Invasive Front through Extracellular Matrix Adaptation in Pancreatic Cancer

March 11, 2026

[International Journal of Cancer] Scientists investigated whether the actin-related protein (Arp) 2/3 complex, a key actin nucleator, is essential for pancreatic ductal adenocarcinoma cells to overcome extracellular matrix stiffness and facilitate migration.

Bioactive and Injectable Granular Hydrogels Incorporating Decellularized Extracellular Matrix

March 11, 2026

[ACS Biomaterials Science & Engineering] Researchers combined the bioactivity of decellularized ECM with the stability of norbornene hyaluronic acid granular hydrogels to create a system that promotes cell adhesion and allows for ECM release.

Targeting the Extracellular Matrix in Precision Medicine: Opportunities for Diagnostics and Therapeutics

March 11, 2026

[Molecular Biology Reports] The authors combine ECM diagnostics, therapeutic targeting strategies, regenerative approaches, and computational models from a single precision medicine viewpoint.

Trevi Therapeutics Announces Completion of End-of-Phase II Meeting with the FDA, Gaining Alignment for Its Development Program for Idiopathic Pulmonary Fibrosis-Related Chronic Cough

March 11, 2026

[Trevi Therapeutics, Inc.] Trevi Therapeutics, Inc. announced the results of its End-of-Phase II meeting with the US FDA. The company plans to conduct two pivotal Phase III clinical trials and has obtained agreement on the remaining Phase I clinical studies that they expect to conduct to support the New Drug Application submission.

Mfsd2a Is Important for Maintaining Epidermal Homeostasis

March 2, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Investigators utilized mouse models of epidermal Mfsd2a deficiency, histological and gene expression analysis, untargeted lipidomics, and human keratinocyte cultures, demonstrating that the epidermal keratinocytes acquire plasma-derived LPC via Mfsd2a mediated transport.

Inhibition of Keratinocyte Necroptosis Mediated by RIPK1/RIPK3/MLKL Provides a Protective Effect against Psoriatic Inflammation

March 2, 2026

[Cell Death & Disease] Scientists provided evidence for the involvement of necroptosis in psoriasis. Receptor interacting protein kinase 1 (RIPK1) and mixed lineage kinase domain-like pseudokinase (MLKL) were significantly upregulated and localized in all layers of the epidermis in human psoriatic lesions, while RIPK3 and phosphorylated MLKL were mainly expressed in keratinocytes, which were located in the upper layers.

A Mechanically Tunable Photo-Cured Hydrogel System Based on Methacrylated Collagen-Keratin Inter-Penetrating Networks for Rapid and Enhanced Wound Healing

March 2, 2026

[International Journal of Biological Macromolecules] Researchers developed injectable photo-cured methacrylated collagen-keratin interpenetrating network hydrogels for rapid enhanced wound healing.

Fufang Baizhi Tincture Protects Melanocytes from Oxidative Stress by Targeting CASP7-Mediated Apoptosis and EP300-Associated Transcriptional Regulation

March 2, 2026

[Journal of Ethnopharmacology] Investigators elucidated the potential mechanism of a traditional therapy for vitiligo and identified CASP7 and EP300 as potential key targets. Fufang Baizhi Tincture likely exerts its protective effects by modulating these targets to regulate melanocyte apoptosis and transcription, providing a robust scientific basis for its clinical application.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.