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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
CircERC1 Facilitates Chemoresistance through Inhibiting Pyroptosis and Remodeling Extracellular Matrix in Pancreatic Cancer
[Molecular Cancer] Scientists revealed a novel circERC1 as a key regulator in pancreatic ductal adenocarcinoma-secreted EVs following paclitaxel treatment, thereby inhibiting gemcitabine/Nab-paclitaxel induced pyroptosis.
Cingulate Retinoic Acid Signaling Regulates Neuropathic Pain and Comorbid Anxiodepression via Extracellular Matrix Homeostasis
[Journal of Clinical Investigation] Scientists uncovered a key role of retinoic acid/RARB signaling in neuropathic pain and associated anxiodepression via regulation of ECM homeostasis.
Shear-Induced Patterning of Decellularized Skeletal Muscle Extracellular Matrix for Enhanced Myogenesis
[Advanced Healthcare Materials] Researchers presented a novel engineering strategy to fabricate and pattern decellularized ECM scaffolds with tunable biophysical properties.
TGFβ-dependent Signaling Drives Tumor Growth and Aberrant Extracellular Matrix Dynamics in NF1-Associated Plexiform Neurofibroma
[Science Advances] Transcriptomic characterization of murine and human plexiform neurofibromasat bulk and single-cell resolution identified transforming growth factor–β (TGFβ) signaling as a key upstream regulator, driving aberrant basement membrane protein production by neoplastic Schwann cells and Fbs.
Deciphering Age-Dependent ECM Remodelling in Liver: Proteomic Profiling and Its Implications for Aging and Therapeutic Targets
[Cell Proliferation] Investigators presented a comprehensive proteomic analysis of the liver ECM across different age stages, uncovering significant age-related changes.
Dysregulation of Extracellular Fibronectin and 5-integrin in Dermal Aging
[Molecular Biology of The Cell] The authors examined human dermal fibroblasts (HDFs) from aged skin and observe that they produce lower extracellular fibronectin densities in vitro than young HDFs.
T16 Modulated Extracellular Matrix Remodeling in Fibroblasts via Paracrine Activation of TGF-β1 through M2 Macrophage Polarization
[Molecular Biology Reports] Scientists investigated how T16 influences fibroblast-mediated ECM remodeling through macrophage polarization.
Acera Surgical Broadens Reach of Restrata® with New FDA Clearance for Soft Tissue Reinforcement
[Acera Surgical (BioSpace)] Acera Surgical announced it has received an additional US FDA clearance for Restrata®, a fully synthetic, fully resorbable electrospun matrix.
Constructing a Co-Culture Model of Cancer-Associated Fibroblasts and Ovarian Cancer Organoids and Studying Mechanisms of Drug Resistance
[Experimental Cell Research] Scientists demonstrated that the integration of cancer associated fibroblasts into an ovarian cancer organoid culture model results in the promotion of tumor growth and the mediation of resistance through multiple signaling pathways.
Inflammatory Oriented Nanospheres-Reconstructed Extracellular Matrix in Ischemic Stroke
[ACS Nano] Researchers proposed a strategy to prevent secondary brain injury and complications by modulating immunity and ECM remodeling.
Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment
[Cancer Research] Scientists delve into the vascular and stromal components of the TME, their contributions to epithelial–mesenchymal transition and resistance mechanisms, and emerging strategies to target these interactions for improved cancer therapy outcomes.
Fibroblast Activation and Heterogeneity in Fibrotic Disease
[Nature Reviews Nephrology] Potential therapeutic strategies for fibrotic diseases include disrupting the formation of the fibrogenic niche, inhibiting fibroblast activation, promoting fibroblast depletion, accelerating fibrosis resolution, or promoting tissue repair and regeneration.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
