Extracellular Matrix News

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Astrocytic Noncanonical WNT5B Signaling Modulates Extracellular Matrix Remodeling and Neuropathology in Huntington’S Disease

January 28, 2026

[Signal Transduction and Targeted Therapy] The noncanonical WNT5B signaling pathway induced sustained expression of matrix metallopeptidase 14 (MMP14), an extracellular matrix (ECM)-degrading enzyme, via activation of the NFATc2 transcription factor in both human and primary mouse astrocytes.

Engineered Perfusable Hepatic Fibrosis Model via Embedded Sacrificial Bioprinting Recapitulates Stiffness-Driven Fibrogenesis

January 28, 2026

[Advanced Materials] Researchers employed embedded sacrificial bioprinting to construct functional liver sinusoid-mimetic vascular networks within hydrogel matrix of precisely tunable elastic modulus, establishing a dynamically perfused in vitro liver fibrosis model.

A Nanosystem Targeting Tissue Inhibitor of Metalloproteinase-1 for Continuous Spatiotemporal Idiopathic Pulmonary Fibrosis Therapy

January 28, 2026

[Nature Communications] Scientists showed a reactive oxygen species-responsive nanosystem targeting tissue inhibitor of metalloproteinase-1 for spatiotemporally precise idiopathic pulmonary fibrosis treatment.

Macrophage-Derived Ferritin Exacerbates Silica-Induced Pulmonary Fibrosis via PIK3R2-Mediated Fibroblast Differentiation

January 28, 2026

[Advanced Science] Multi-omics profiling and co-culture experiments revealed that macrophage–secreted ferritin promotes fibroblast-to-myofibroblast differentiation and pathological extracellular matrix (ECM) deposition via the PIK3R2/SMAD signaling axis.

Calumenin Prevents Fibroblast Senescence and Lung Aging by Promoting Vimentin Proteostasis

January 28, 2026

[Proceedings of the National Academy of Sciences of the United States of America] The authors identify the critical role of calumenin in maintaining vimentin proteostasis and regulating fibroblast senescence.

Silk Fibroin Scaffolds Loaded with Growth Factors Can Reverse Liver Fibrosis

January 28, 2026

[Biomaterials Science] Regenerated silk fibroin scaffolds, with or without hepatocyte growth factor and fibroblast growth factor-4, were implanted onto the liver surface to assess antifibrotic efficacy.

Cancer-Associated Fibroblasts: Enablers of Tumor Drug Resistance

January 28, 2026

[Journal of Translational Medicine] The authors integrate recent literature and synthesize evidence from both preclinical and clinical studies to elucidate the potential mechanisms by which cancer-associated fibroblasts (CAFs) contribute to therapeutic resistance and to summarize up-to-date research developments in nanotherapeutic strategies targeting CAFs.

Matrix Metalloproteinases in Periodontal and Peri-Implant Diseases: Contribution to Their Pathogenesis, Diagnosis, and Treatment

January 28, 2026

[Journal of Periodontal Research] Scientists examine the pathogenic mechanisms, diagnostic applications, and therapeutic targeting potential of the entire matrix metalloproteinases family in periodontitis and peri-implantitis.

Rein Therapeutics Receives Orphan Drug Designation from European Medicines Agency for Lead Drug Candidate in Idiopathic Pulmonary Fibrosis

January 28, 2026

[Rein Therapeutics] Rein Therapeutics announced that it has received orphan drug designation from the European Medicines Agency for LTI-03, its lead drug candidate aimed at preserving lung function in patients with idiopathic pulmonary fibrosis.

Brain and Neural Cell Type Proteomics Reveal Extracellular Matrix Proteins Enriched in Progressive Multiple Sclerosis

January 14, 2026

[Nature Communications] Scientists highlighted the importance of ECM protein induction in central nervous system glial cells during progressive multiple sclerosis while providing potential therapeutic targets for future investigation.

Bioinspired Microgel Assembly of Liver-Derived Decellularized Extracellular Matrix Enhances Dentin-Pulp Regeneration via Stemness Awakening

January 14, 2026

[Advanced Healthcare Materials] Investigators developed an injectable microgel scaffold composed of porcine liver-derived decellularized ECM and gelatin methacryloyl.

Triple-Remodeling of Tumor Microenvironment through Hyaluronidase-Assisted Folate-Targeted Lipid Nanoparticle-Mediated siVEGF/siPD-L1 for Enhanced Tumor Immunotherapy

January 14, 2026

[Journal of Translational Medicine] Researchers created an efficient combined anti-tumor lipid nanoparticle (LNP) delivery system. They added DMG-PEG2000-FA to the four-component lipid nanoparticle system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.