NewslettersExtracellular Matrix News SIRT5 Ameliorates Cardiac Fibrosis via PCK2 Desuccinylation-Mediated Metabolic Reprogramming in Cardiac Fibroblasts By Jamie Kang - April 23, 2026 0 12 The functional role of SIRT5 in cardiac fibrosis was evaluated through cardiac fibroblast-specific knockout and overexpression of Sirt5 in mice. [Circulation] Abstract