Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Extracellular Matrix News
Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Tissue Mechanics in Tumor Heterogeneity and Aggression
[Trends in Cancer] Scientists discuss the role of the ECM in driving cancer aggression through its impact on tumor heterogeneity.
The Dynamic Interplay between Melanoma Cells and CAFs: Implications Drug Resistance and Immune Evasion and Possible Therapeutics
[Experimental Cell Research] The authors explore different subtypes of cancer-associated fibroblasts, their origins, and how they have evolved in their pro-tumorigenic roles in melanoma.
Selective Inhibition of Stromal Mechanosensing Suppresses Cardiac Fibrosis
[Nature] Scientists demonstrated across multiple scales that inhibition of matrix mechanosensing in persistently activated cardiac fibroblasts potentiates—in concert with soluble regulators of the TGFβ pathway—a robust transcriptomic, morphological, and metabolic shift towards quiescence.
3D Bioprinting of Collagen-Based High-Resolution Internally Perfusable Scaffolds for Engineering Fully Biologic Tissue Systems
[Science Advances] Investigators three-dimensionally bioprinted ECM and cells into collagen-based high-resolution internally perfusable scaffolds that integrate with a vascular and perfusion organ-on-a-chip reactor to form a complete tissue engineering platform.
FluidForm Bioâ„¢ Strengthens IP Portfolio with Newly Issued Patent on Key Aspects of its Proprietary FRESHâ„¢ Platform
[FluidForm Bio] FluidForm Bioâ„¢ announced that the United States Patent and Trademark Office has issued a new patent which expands the foundational intellectual property exclusively licensed to the company from Carnegie Mellon University around Freeform Reversible Embedding of Suspended Hydrogels (FRESHâ„¢).
Collagen Type VI Regulates TGF-β Bioavailability in Skeletal Muscle in Mice
[Journal of Clinical Investigation] Researchers identified a conspicuous dysregulation of the TGF-β pathway early in the disease process and proposed that the collagen VI–deficient matrix is not capable of regulating the dynamic TGF-β bioavailability both at baseline and in response to muscle injury.
Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity
[Nature Communications] Fibroblasts on viscoelastic substrates display larger nuclei, lower chromatin compaction, and differential expression of distinct sets of genes related to the cytoskeleton and nuclear function, compared to those on elastic surfaces.
FesariusTherapeutics Announces Manufacturing Agreement for DermiSphere hDRT, the first hydrogel Dermal Regeneration Template
[FesariusTherapeutics, Inc. ] FesariusTherapeutics, Inc. announced it has entered into an exclusive, multi-year manufacturing and supply agreement with Regenity Biosciences. The agreement provides Regenity exclusive manufacturing responsibility for DermiSphere hDRT, an new class of collagen-based dermal regeneration templates.
Faster Amylin Aggregation on Fibrillar Collagen I Hastens Diabetic Progression through β-Cell Death and Loss of Function
[Journal of The American Chemical Society] Researchers showed how amylin incorporation in islet matrices through amylin–Col interactions drives type 2 diabetes progression by impacting β-cell viability and insulin secretion.
Mechanical Signatures and Models of the Bone Marrow Niche
[Nature Reviews Bioengineering] The authors explore the structure–function relationship of the bone marrow, emphasizing its complex mechanical behaviour, and discuss the bioengineered models that recapitulate the mechanical properties in the healthy and diseased bone marrow niche.
Fibroproliferative Conditions: The 3R Approach Bridging Fibrosis and Tumors
[Trends In Molecular Medicine] Scientists proposed a new, more clinically grounded, fibroproliferative condition classification that is based on the intent and severity of the fibroproliferation.
The Chemical Chaperone 4-Phenylbutyric Acid Rescues Molecular Cell Defects of COL3A1 Mutations That Cause Vascular Ehlers Danlos Syndrome
[Cell Death Discovery] Analysis of two novel COL3A1 glycine mutations, G189S and G906R, in primary patient fibroblast cultures revealed secretion of misfolded collagen III and intracellular collagen retention leading to lower extracellular collagen levels.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
