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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
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Extracellular Matrix-Guided Hierarchical Assembly of Self-Powered Patches for Stress Relaxing, Wireless Monitoring, and Accelerated Healing of Pressure Ulcers
[ACS Nano] Scientists underscored an ECM-guided design for real-time monitoring and timely interventions in pressure ulcers.
Platelet-Bioengineered hiPSC-sEVs Achieve Targeted Repair of Fibrotic Sinoatrial Node in Preclinical SND Models
[Nature Communications] Researchers engineered platelet membrane-fused vesicles that synergistically combine collagen targeting for ischemic injury homing with immune evasion.
Inhibiting the Formation of Neutrophil Extracellular Traps to Prevent the Recurrence of Post-Operative Glioblastoma
[Nature Communications] Investigators focused on the important roles of neutrophil extracellular traps in the progression of glioblastoma in mice and patients.
Unraveling the YAP1-TGFβ1 Axis: A Key Driver of Androgen Receptor Loss in Prostate Cancer-Associated Fibroblasts
[Journal of Experimental & Clinical Cancer Research] Scientists demonstrated that our newly generated cancer-associated fibroblasts biobank contains three FAP+-fibroblast subtypes, each with unique molecular and functional traits.
Structurally and Functionally Optimized Silk Fibroin-Alginate-Based Biomimetic Scaffolds Reinforced with Nanobioceramics for Bone Tissue Engineering Applications
[Journal of Nanobiotechnology] Investigators prepared chemically crosslinked silk fibroin and sodium alginate biomimetic scaffolds reinforced with bioceramic nanohydroxyapatite for bone tissue engineering applications.
Multiorgan Fibrosis and Risk of Type 2 Diabetes: Genetic and Observational Evidence Highlighting a Causal Role of Pancreatic Fibrosis
[Diabetes] Researchers found a potential causal and organ-specific role of pancreatic fibrosis in the pathogenesis of type 2 diabetes, highlighting pancreatic fibrosis as a mechanistically plausible and potentially targetable target in diabetes prevention.
TGF-β1 Directs TFAM-Mediated Mitochondrial Reprogramming in Oral Submucous Fibrosis
[Journal of Dental Research] The authors evaluated the effects of arecoline and transforming growth factor-β on the mitochondrial bioenergetics and phenotype of oral fibroblasts.
Eriocitrin Mitigates Osteoarthritis Development by Suppressing Chondrocyte Inflammation and ECM Degradation via Nrf2/HO-1/NF-κB Pathways
[Journal of Agricultural and Food Chemistry] Scientists investigated the impact of eriocitrin on interleukin-1β-induced inflammation in murine chondrocytes and assessed its therapeutic efficacy in a murine osteoarthritis model.
Pulmonary Fibrosis in Post-COVID-19: Epithelial-Mesenchymal Transition As a Key Mechanism and Target for Therapy
[Inflammopharmacology] The authors focus on the mechanism of post-COVID-19 pulmonary fibrosis through epithelial-mesenchymal transition with special importance to TGF-β/Smad, NF-κB pathways, and oxidative stress.
FibroBiologics Files Patent Application Covering Novel Fibroblast-Based Chondrocyte Spheroid Platform for Orthopedic and Musculoskeletal Conditions
[FibroBiologics, Inc.] FibroBiologics, Inc. announced that it has submitted a new patent application with the US Patent and Trademark Office titled “Spheroids For Cartilage Repair” covering a proprietary fibroblast-derived therapy platform for use in orthopedic and musculoskeletal conditions, including degenerative disc repair, cartilage repair, and joint restoration.
Remodelling of the Endothelial Extracellular Matrix Promotes Smooth Muscle Cell Hyperplasia in Pulmonary Hypertension Due to Left Heart Disease
[Cardiovascular Research] The authors investigated the role of the endothelial extracellular matrix, specifically the pulmonary arterial basement membrane, in influencing smooth muscle cell proliferation and phenotypic changes in pulmonary hypertension secondary to left heart disease.
Catalyst-Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds
[Advanced Science] A bioorthogonal crosslinking strategy using rhodamine and polyethylene glycol was reported to fabricate dense, mechanically reinforced collagen hydrogels.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
