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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
TET3 Is a Regulator and Can Be Targeted for the Intervention of Myocardial Fibrosis
[EMBO Molecular Medicine] Scientists reported that TET3 depletion in cultured cardiac fibroblasts blocked transition to myofibroblasts in response to different pro-fibrogenic stimuli.
Mechanosensitive Biochemical Imprinting of the Talin Interaction with DLC1 Regulates RhoA Activity and Cardiomyocyte Remodeling
[Science Advances] Scientists identified that the talin interacting proteins deleted in liver cancer 1 (DLC1), Rap1-interacting adaptor molecule, and paxillin each preferentially bind to talin at a specific ECM stiffness.
Chemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues
[Advanced Materials] Scientists presented a glycosylation-enabled, chemoselective strategy to label, enrich, and characterize newly synthesized ECM proteins with augmented specificity and sensitivity.
Local Photocrosslinking of Native Tissue Matrix Regulates Lung Epithelial Cell Mechanosensing and Function
[Nature Materials] Using visible-light-mediated photochemistry, researchers induced local crosslinking and stiffening of ECM proteins within ex vivo mouse and human lung tissue.
ECM-Induced IL-23 Drives Immune Suppression in Breast Cancer via Regulating PD-1 on Tregs
[Journal of Experimental & Clinical Cancer Research] Scientists investigated the impact of the ECM on T cell regulation in high-grade breast cancerpatients, focusing on the relationship between ECM3+ tumors and T cell phenotypes.
Unravelling the Genetics and Epigenetics of the Aging Tumor Microenvironment in Cancer
[Nature Reviews Cancer] Epigenetic changes, including DNA methylation and histone modifications, can drive various hallmarks of ageing in precancerous cells. They also alter the normal immune and stromal cells in the TME, which cumulatively enhances the effects of cancer driver mutations.
United Therapeutics Corporation Announces TETON-2 Pivotal Study of Tyvaso® Meets Primary Endpoint for the Treatment of Idiopathic Pulmonary Fibrosis
[United Therapeutics Corporation] United Therapeutics Corporation announced that its TETON-2 study evaluating the use of nebulized Tyvaso® Inhalation Solution for the treatment of idiopathic pulmonary fibrosis met its primary efficacy endpoint of demonstrating improvement in absolute forced vital capacity relative to placebo.
Procollagen IIA Mediates Positive Feedback Control of the Mouse Cardiogenic Transcriptional Network
[Proceedings of the National Academy of Sciences of the United States of America] Investigators revealed IIA procollagen as a key ECM component that integrates BMP/TGFβ signaling with cardiac transcription factors such as NKX2-5, revealing a feedback loop essential for cardiogenesis.
3D-Printed Extracellular Matrix-Mimicking Hydrogels Derived from Multiple Tissues for Integrated Construction of Complex Organs
[Advanced Healthcare Materials] A set of extracellular matrix-mimicking hydrogels derived from multiple animal tissues was described, which meets the regeneration needs of multiple tissues after xenotransplantation.
Absorbable Adhesive Composite Hemostatic Sponge Based on Decellularized Extracellular Matrix and Mussel Adhesive Protein for Internal Bleeding Control
[Advanced Healthcare Materials] Researchers highlighted the potential of ECM-MAP sponges as absorbable, adhesive hemostats for internal bleeding control and early-stage wound stabilization.
Biomechanics of the Tumor Extracellular Matrix and Regulatory T Cells: Regulatory Mechanisms and Potential Therapeutic Targets
[Cell Communication and Signaling] The authors review the molecular events through which ECM mechanical properties, such as stiffness, viscoelasticity, and topological structure, regulate Treg identity and functionality, as well as the mechanical sensing and response mechanisms employed by Tregs.
Dual Roles and Therapeutic Targeting of Tumor-Associated Macrophages in Tumor Microenvironments
[Signal Transduction and Targeted Therapy] This review synthesizes tumor-associated macrophage (TAMs) biology, immune crosstalk, and therapeutic advancements, providing a foundation for novel oncology strategies aimed at reprogramming TAMs to overcome treatment resistance and improve clinical outcomes.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
