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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
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Multicellular Force Coordination Constructs Microchannel Networks for Barrier-Free Metastasis across Extracellular Matrix
[Science Advances] Researchers revealed that cancer cells collaboratively reprogram ECM to construct interconnected microchannel networks functioning as “superhighways” for barrier-free metastasis.
Cancer-Associated Fibroblasts in the Tumor Microenvironment: Heterogeneity, Crosstalk Mechanisms, and Therapeutic Implications
[Molecular Cancer] The authors discuss recent advancements in our understanding of the heterogeneity of cancer-associated fibroblasts (CAFs), elucidate their multifaceted interactions within the TME, and explore novel therapeutic strategies targeting CAFs across various cancer types.
EGLN1 (PHD2) Role in Tumor Microenvironment: Insights for Therapeutic Targeting
[Experimental & Molecular Medicine] Scientists explore the role of this protein in some of the key components of the TME, focusing on the functions of EGLN1/PHD2 in endothelial, stromal and immune cells.
Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction
[Advanced Healthcare Materials] Scientist defined the pro-reparative nature of the decellularized ECM biomaterial on cardiac cell types and elucidate previously undiscovered therapeutic pathways, further demonstrating the potential of intravascularly infusible ECM as an myocardial infarction therapy.
In Vitro Evaluation of Verteporfin and Exploration of TEAD Palmitoylation Inhibition in Piezo1-YAP/TAZ Signaling and ECM Remodeling
[Scientific Reports] Scientists focused on how YAP/TAZ–TEAD regulates transcriptional activation and ECM remodeling using pharmacological modulation and functional inhibition approaches.
Inhibition of the Mevalonate Pathway Targets Neuroblastoma Stem Cells
[Pharmacology] Researchers observed the use of mevalonate pathway inhibitors against the CSC population of high-risk neuroblastoma cell lines SH-SY5Y, SK-N-AS, and SK-N-BE(2)-C using spheroid-based assays.
Targeting CTGF Overcomes Resistance to CSF1R Inhibitors by Preventing CAF Activation in Colorectal Cancer
[Cell Reports Medicine] Through imaging mass cytometry, researchers revealed that the CSF1R inhibitor PLX3397 indirectly activates cancer-associated fibroblasts, impedes T cell infiltration, and suppresses T cell function.
Extracellular Matrix-Guided Hierarchical Assembly of Self-Powered Patches for Stress Relaxing, Wireless Monitoring, and Accelerated Healing of Pressure Ulcers
[ACS Nano] Scientists underscored an ECM-guided design for real-time monitoring and timely interventions in pressure ulcers.
Platelet-Bioengineered hiPSC-sEVs Achieve Targeted Repair of Fibrotic Sinoatrial Node in Preclinical SND Models
[Nature Communications] Researchers engineered platelet membrane-fused vesicles that synergistically combine collagen targeting for ischemic injury homing with immune evasion.
Inhibiting the Formation of Neutrophil Extracellular Traps to Prevent the Recurrence of Post-Operative Glioblastoma
[Nature Communications] Investigators focused on the important roles of neutrophil extracellular traps in the progression of glioblastoma in mice and patients.
Unraveling the YAP1-TGFβ1 Axis: A Key Driver of Androgen Receptor Loss in Prostate Cancer-Associated Fibroblasts
[Journal of Experimental & Clinical Cancer Research] Scientists demonstrated that our newly generated cancer-associated fibroblasts biobank contains three FAP+-fibroblast subtypes, each with unique molecular and functional traits.
Structurally and Functionally Optimized Silk Fibroin-Alginate-Based Biomimetic Scaffolds Reinforced with Nanobioceramics for Bone Tissue Engineering Applications
[Journal of Nanobiotechnology] Investigators prepared chemically crosslinked silk fibroin and sodium alginate biomimetic scaffolds reinforced with bioceramic nanohydroxyapatite for bone tissue engineering applications.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
