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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
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Catalyst-Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds
[Advanced Science] A bioorthogonal crosslinking strategy using rhodamine and polyethylene glycol was reported to fabricate dense, mechanically reinforced collagen hydrogels.
Regulation of the Mechanoresponsive Neat1 and PSPC1 by Substrate Stiffness in TGF-β1-Induced Renal Progenitor Cell Fate
[Journal of Biomedical Science] Scientists found that TGF-β1 induced mouse kidney progenitor cell differentiation into myofibroblasts on stiff matrices or endothelial-like cells on soft matrices. Matrix stiffness regulated PSPC1 and Neat1 to trigger either TGF-β1-induced transdifferentiation into myofibroblasts or angiogenesis on soft collagen gels.
Extracellular-Matrix-Based Materials from Decellularized Tissue: Opportunities, Challenges, and Future Directions in Regenerative Medicine
[Advanced Healthcare Materials] Clinical use of current decellularized tissue (dECM) biomaterials, advances in the fabrication of dECM biomaterials, and hurdles to clinical translation of dECM products are discussed.
The Differential Effects of cAMP Mobilizing Agents on TGF-β-Induced Extracellular Matrix in Human Lung-Derived Fibroblasts: Insights Into Therapeutic Targets for Lung Fibrosis
[Respiratory Research] As a model of lung fibrosis, primary human lung fibroblasts derived from non-idiopathic pulmonary fibrosis (IPF) and IPF donors were stimulated with TGF-β; collagen 1A1 and plasminogen activator inhibitor-1 expression were then measured in the presence and absence of cAMP-mobilizing agents.
Progesterone Receptor Membrane Component 1 Accelerates Liver Fibrosis by Interacting with Transforming Growth Factor β Receptor
[Life Sciences] Investigators demonstrated that progesterone receptor membrane component 1 plays a crucial role in liver fibrosis progression by regulating TGF-βR, highlighting its potential as a promising therapeutic target for antibody-based treatment.
PDGF-BB Inhibits F-Actin Formation and Chondrocyte Dedifferentiation in Osteoarthritis via Oxygen-Dependent HIF-1α/SCIN Regulation and RhoA/ROCK Signaling Inhibition
[European Journal of Pharmacology] Scientists investigated the therapeutic potential of platelet-derived growth factor (PDGF)-BB, delivered via sodium hyaluronate, in modulating osteoarthritis chondrocyte microstructure and cytoskeletal dynamics.
Biodegradable Magnesium-Calcium Mineralized Collagen Metal Materials Inhibits Invasion and Metastasis of Osteosarcoma
[Scientific Reports] Researchers examined the application of magnesium-based metallic materials for osteosarcoma treatment, specifically assessing the impact of a magnesium-calcium alloy/mineralized collagen composite on osteosarcoma cell biological behavior.
A Three-Dimensional Microporous Decalcified Bone Matrix Combined with Bone Marrow Mesenchymal Stem Cells Enhances Bone Regeneration in Critical-Sized Calvarial Defect of Nude Mouse
[ACS Applied Bio Materials] Scientists investigated a three-dimensional microporous demineralized bone matrix combined with bone marrow mesenchymal stem cells to enhance the outcomes of bone defect repair.
Tumor Microenvironment-Mediated Immune Evasion and Resistance in Prostate Cancer: Mechanisms, Cross-Talk, and Therapeutic Opportunities
[Clinical and experimental medicine] The authors present a comprehensive and multi-dimensional analysis of the cellular, stromal, and molecular constituents of the immunosuppressive tumor microenvironment in prostate cancer, highlighting its significant heterogeneity and context-dependent functions.
Macomics Announces Updated Data of the ENIGMAC Drug Discovery Platform and The Role of Macrophages in Fibrotic Disease
[Macomics Ltd,] Macomics, Ltd. announces that it has validated its ENIGMAC™ platform in macrophage mediated antifibrotic therapy. The drug discovery platform is designed to discover therapeutic targets and unlock disease specific target biology.
The Emerging Role of Cancer-Associated Fibroblasts in Hematological Malignancies: From Their Influence on Tumor Progression and Drug Resistance to Novel Therapeutic Opportunities
[Clinical and Experimental Medicine] The authors discuss the current understanding of cancer-associated fibroblasts' pro- or anti-tumor functions in various hematological malignancies, including acute and chronic leukemia, lymphoma, and multiple myeloma.
Mechanobiology and Resolution of Lung Fibrosis
[Annual Review of Physiology] Scientists review the mechanobiology of the healthy lung and the feedback loops that promote fibrosis progression. They lay out the challenges and opportunities for targeting the fibrotic matrix as an essential element for protecting or restoring lung function.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
