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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
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The Emerging Role of Cancer-Associated Fibroblasts in Hematological Malignancies: From Their Influence on Tumor Progression and Drug Resistance to Novel Therapeutic Opportunities
[Clinical and Experimental Medicine] The authors discuss the current understanding of cancer-associated fibroblasts' pro- or anti-tumor functions in various hematological malignancies, including acute and chronic leukemia, lymphoma, and multiple myeloma.
Mechanobiology and Resolution of Lung Fibrosis
[Annual Review of Physiology] Scientists review the mechanobiology of the healthy lung and the feedback loops that promote fibrosis progression. They lay out the challenges and opportunities for targeting the fibrotic matrix as an essential element for protecting or restoring lung function.
Regulation of Corneal Stromal Cell Behavior by Modulating Curvature Using a Hydraulically-Controlled Organ Chip Array
[Nature Communications] Investigators developed a hydraulically controlled curvature array chip recapitulating disease-relevant geometries to investigate how keratocytes, fibroblasts, and myofibroblasts respond to geometric stress.
An Extracellular Matrix-Producing Subset of Cancer-Associated Fibroblasts Drives Chemoresistance in Breast Cancer via SRC Activation and G0S2 Upregulation
[Cancer Research] By combining analysis of data from TNBC patients with ex vivo modeling using tumor-on-chip technology, researchers identified a specific cancer associated fibroblasts population, the extracellular matrix-producing myofibroblasts, that mediated resistance to chemotherapy.
Temporal Dynamics of ADSC Therapy in Skin Fibrosis: Unraveling the Roles of ROS/NF-κB/TSG-6 Signaling Axis
[Stem Cell Research & Therapy] Researchers elucidated the temporal hierarchy and mechanistic underpinnings of adipose-derived stem cell-mediated fibrosis resolution using a bleomycin-induced murine localized scleroderma model.
Targeting the Extracellular Matrix with Tenascin-C-Specific CAR T Cells Extends Survival in Preclinical Models of Glioblastoma
[Journal for Immunotherapy of Cancer] To broaden the range of tumor-restricted antigens, researchers developed CAR T cells targeting Tenascin-C, a secreted extracellular matrix protein that is overexpressed in glioblastoma and plays a critical role in tumor progression.
Cancer-Associated Fibroblasts Drive Lung Adenocarcinoma Progression via THBS2-Mediated Epithelial-Mesenchymal Transition
[Oncogene] Investigators utilized single-cell RNA sequencing, spatial transcriptomics, and a combination of in vivo and in vitro models to decode the dynamics of tumor-stroma interactions during human lung adenocarcinoma progression.
IL-5 Signaling in Asthmatic Derived Fibroblasts Exacerbates Airway Remodeling through ECM Dysregulation and Apoptosis Resistance
[Respiratory Research] IL-5 directly activates lung fibroblasts to drive airway remodelling in severe asthma through ECM deposition, matrix metalloproteinase/tissue inhibitor of metalloproteinasesimbalance, and pro-fibrotic cytokine secretion, positioning it as a dual mediator of inflammation and fibrosis with novel therapeutic potential.
NeXtGen Biologics and Lovell® Government Services Partner to Bring Innovative Advanced Wound Care Technology to Federal Healthcare Systems
[NeXtGen™ Biologics, Inc. (GlobeNewswire)] Lovell® Government Services and NeXtGen™ Biologics, Inc., a medical device company that manufactures NeoMatriX® announced that they have partnered to serve federal healthcare, including the Veterans Health Administration, the Military Health System, and the Indian Health Service. NeoMatriX® is a collagen wound matrix uniquely derived from the ECM of the axolotl.
YAP1 Reactivation in Cardiomyocytes following ECM Remodelling Contributes to the Development of Contractile Force and Sarcomere Maturation
[Cell Death Discovery] The authors employed mechanical actuation as a proxy reproducing extracellular matrix remodelling in vitro to trigger YAP1 nuclear shuttling in contractile cardiomyocytes derived from hESCs and iPSCs.
PDE5A+ Cancer-Associated Fibroblasts Enhance Immune Suppression in Gastric Cancer
[Gut] Researchers identified a critical subpopulation of cancer-associated fibroblasts in promoting an immunosuppressive tumor microenvironment and enabling immune evasion, which may influence the therapeutic effectiveness of immune checkpoint inhibitors for gastic cancer.
Dynamic Urinary Proteomics Integrates Single-Cell and Spatial Transcriptomics to Reveal Tumor Microenvironment and Predict Immunotherapy Response in Biliary Tract Cancer
[Gut] Scientists established urinary proteomics as a predictive tool for immune checkpoint inhibitor responsiveness and to elucidate its relationship with tumor dynamics and tumor microenvironment remodeling in biliary tract cancer.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
