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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Suppression of the Prostaglandin I2–Type 1 Interferon Axis Induces Extramedullary Hematopoiesis to Promote Cardiac Repair after Myocardial Infarction
To assess the role of spleen extramedullary hematopoiesis (EMH) in myocardial infarction (MI), scientists constructed a Tcf21CreER Scfflox/flox MI mouse model with inhibited EMH.
[Circulation] Full...
Overexpressing Natural Killer Group 2 Member a Drives Natural Killer Cell Exhaustion in Relapsed Acute Myeloid Leukemia
[Signal Transduction and Targeted Therapy] Researchers investigated NK cell exhaustion in relapsed AML patients following allogeneic hematopoietic stem cell transplantation through phenotypic assessments, functional assays, and RNA sequencing analyses.
PIEZO1 Activation-Mediated Generation of Transgene-Free Long-Term Hematopoietic Stem Cells
[American Journal of Hematology] Investigators found that pulsation-mediated circumferential stretch was restricted to the ventral part of the dorsal aorta and activated Piezo1 to stimulate long-term reconstituting hematopoietic stem cells formation.
Outcomes of Allogeneic Haemopoietic Transplant for Chronic Lymphocytic Leukaemia in the Modern Era
[Internal Medicine Journal] Scientists examined the use of HSCT performed for chronic lymphocytic leukaemia in Australia and New Zealand, including patients exposed to pathway inhibitors prior to transplant.
Emerging Therapeutic Approaches for Anemia in Myelofibrosis
[Current Hematologic Malignancy Reports] The authors highlight conventional agents and novel emerging therapeutic strategies to treat anemia in myelofibrosis.
CERo Therapeutics Holdings, Inc. Announces TriStar Centennial Medical Center as a Clinical Trial Site for its Phase I Clinical Trial of CER-1236 in Acute...
[CERo Therapeutics, Inc.] CERo Therapeutics Holdings, Inc. announced that TriStar Centennial Medical Center, through Sarah Cannon Research Institute, in Nashville, Tennessee, is a clinical trial site for the Company’s Phase I clinical of CER-1236.
Somatic Mutations and Outcomes in Chronic Myeloid Leukemia Adolescent and Young Adults Compared to Children, Adults, and BCR::ABL1-Positive Acute Lymphoblastic Leukemia
[Leukemia] This real-life study compared mutation profiles and their impact on outcomes in 80 adolescent and young adults, 97 adult, and 16 pediatric chronic myeloid leukemia in chronic phase patients, alongside 81 BCR::ABL1-positive acute lymphoblastic leukemia patients.
Universal Fibroblasts across Tissues Can Differentiate into Niche Cells for Hematopoietic Stem Cells
[Cell Reports] Scientists demonstrated that CD248+ universal fibroblasts from the lung and colon outside the skeletal system generated CXCL12-abundant reticular/leptin-receptor-expressing cells characterized by HSC niche functions.
Complosome As a New Intracellular Regulatory Network in Both Normal and Malignant Hematopoiesis
[Leukemia] Investigators proposed that the complosome, like its role in lymphocytes, is necessary for the optimal function of mitochondria in hematopoietic cells, including hematopoietic stem progenitor cells.
Possible Impacts of Cosmic Radiation on Leukemia Development during Human Deep Space Exploration
[Leukemia] The authors provide a comprehensive review of the various studies and evidence available on Earth and in space assessing the relationship between ionizing radiation and increased risk of leukemia.
The Mitochondrial Protease ClpP Is a Metabolic Vulnerability and an Immunogenic Trigger against Multiple Myeloma.
[Blood] Scientists showed that the mitochondrial protease ClpP is both a cell-intrinsic metabolic vulnerability and an actionable immunogenic trigger in multiple myeloma.
The Protein Deacetylase HDAC10 Controls DNA Replication in Malignant Lymphoid Cells
[Leukemia] Researchers demonstrated that human cultured and primary acute B cell/T cell leukemia and lymphoma cells required the catalytic activity of HDAC10 for their survival.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
